The effects of cochleostomy of hearing threshold in animal experiment

• Authors: Olimpia Stanisławek-Sut , Krzysztof Morawski , Kazimierz Niemczyk

Abstracts

EN

SUMMARY Introduction: To assess an effect of cochleostomy on hearing threshold in guinea pigs. Material and methods: The authors performed animal experiments using fi ve 3-month-old guinea pigs. Before experiment hearing threshold were evaluated. Surgery involved access to the temporal bone by a post-auricular incision. After a wide opening of the bulla cochleostomy was created (10 000 turn/min, diamond bur of 0,8 mm diameter). Hearing threshold was identifi ed on the basis of presence of wave V in auditory brainstem responses (ABR) for click and frequency-specifi c stimulation. Also morphology and latency changes for wave V for this stimulation was assesed. Hearing status was evaluated before, just after and 1-, 2-, and 4-weeks after surgery. For surgical procedure and ABR examination all animals were anesthetized with an intramuscular injection of ketamine (50 mg/kg) mixed with xylazine (9 mg/kg) in the supplemental doses. After surgery the animal was treated by antibioticoterapy for 3 days – Enrofl oksacyna 0,3 ml subcutaneouly and analgesic – Tolfedine 0,05 mg in second day. Results: Four week observation of ABR morphology and hearing thresholds for click and frequency-specifi c stimulation of 100 dB SPL intensity showed only temporary changes confi rming that cochleostomy did not affect cochlear function. Conclusions: The correctly performed cochleostomy in guinea pigs did not affect persistently the cochlear function indicating that such an option of CI electrode insertion in patients is safe.

Keywords

EN

guinea pig; cochleostomy; hearing threshold

• Journal: Otolaryngologia Polska
• Year: 2010
• Volume: 64(7)
• Pages: 17-21

Dates

published

2018-04-27

Contributors

author

Olimpia Stanisławek-Sut

author

Krzysztof Morawski

author

Kazimierz Niemczyk