Cysteinyl leukotriene 1 receptor expression in nasal polyps

• Authors: Małgorzata Różańska , Paweł Bielecki , Joanna Reszeć , Krzysztof Kowal , Marek Rogowski

Abstracts

EN

Cysteinyl leukotrienes (CysLTs) have been implicated in the pathogenesis of chronic rhinosinusitis (CRS). This study was undertaken to better understand the role of CysLTs in the development of CRS through 1). assessment of the pattern of expression of CysLT1 receptor in nasal polyps from patients with CRS and 2). correlation of expression of CysLT1 receptor with clinical features. Expression of CysLT1 receptor was evaluated immunohistochemically in nasal polyps from 20 patients with CRS and nasal mucosa from 10 control subject undergoing plastic surgery of the nose. Patients with CRS showed significantly higher expression of CysLT1 receptor as compared with the control group (p<0.05). The expression of CysLT1 receptor in sub-epithelial inflammatory infiltrates tended to be higher in patients with CRS and allergy as compared with patients with CRS but without allergy (p=0.07). In particular, the expression of CysLT1 receptor in sub-epithelial inflammatory infiltrates was significantly greater in 3 patients with CRS and drug allergy as compared with patients with CRS but without drug allergy (p=0.03). Increased expression of CysLT1 receptor in inflamed mucosa of nasal polyps in patients with allergy might suggest particular role of CysLTs in the pathogenesis of nasal polyps in this group of patients.

Keywords

EN

polipy nosa; przewlekłe zapalenie zatok; leukotrieny

• Journal: Otolaryngologia Polska
• Year: 2018
• Volume: 72(6)
• Pages: 17-22

Dates

published

2018-09-26

Contributors

author

Małgorzata Różańska

author

Paweł Bielecki

author

Joanna Reszeć

author

Krzysztof Kowal

author

Marek Rogowski

Identifiers

DOI

10.5604/01.3001.0012.5422