PL EN


Preferences help
enabled [disable] Abstract
Number of results
2008 | 62(6) | 674-679
Article title

Expression of activation antigens on the lymphocytes T in patients with carcinoma of the larynx and connection with tumor features

Content
Title variants
Languages of publication
Abstracts
EN
Introduction. Results of studies analyzing the role of immunocompetent cells in tumor environment and whole peripheral blood indicate their responsibility for aggressiveness of neoplasm, prognosis and therapeutic effect. Atcivation of lymhocytes T is connected with expression the markers (antigens) on their surface. The aim of this study was the analysis of activation antigens expression on lymphocytes T in patients with laryngeal carcinoma and the connection with clinicomorphological features. Material and methods. Analysis of activation antigens expression CD69, CD71 and CD25, CD26, HLA/DR on lymphocytes T CD4+ i CD8+ in 33 patients with squamous cell carcinoma of the larynx was performed. Flow cytometry-based analysis of activation antigens in T cell cultures with and without PHA stimulation was used. The connection of these molecules and clinicomorphological features was examined (pT, pN, G, Anneroth, Batsakis and Lunas’ classifi cation). Results. The signifi cant correlation between chosen markers of activation and tumor features were noted: pT with HLA/DR/CD4, CD69CD8, CD71CD8, pN with CD26CD8, G with CD25CD8, CD71CD8, ABL score with CD25CD4. Conclusion. Our data indicated the connetion of immunocompetent cell activity and spread of neoplasm in patients with laryngeal carcinoma.
Year
Volume
Pages
674-679
Physical description
Dates
published
2018-04-30
References
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.ceon.element-a503d964-6295-356e-bda7-7d9b6e6deb86
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.