Antioxidative assessment of new trans-palladium (II) complexes in head and neck cancer

• Authors: Katarzyna Malinowska , Dariusz Kaczmarczyk , Radosław Zajdel , Anna Merecz-Sadowska , Jurek Olszewski , Małgorzata Majczyk , Alicja Nowak-Zduńczyk , Hanna Zielińska-Bliźniewska

Abstracts

EN

Background: Head and neck neoplasms stand for 6% of all malignant neoplasms worldwide. Chemotherapy has limited use due to the biological properties of the tumor (in the majority of cases moderately and poorly differentiated squamous cell carcinoma). The fundamental molecule used in treatment is cisplatin and its derivates, that can be associated with fluorouracil. The new chemotherapeutic agents are not in common use during the treatment of head and neck malignancies. However, the use of low molecular weight complexes Pd (II) carries the potential of being more effective in therapy. Material and Methods: Fifty-one patients, 30 men and 21 women (aged 52.9 ± 12.1 years) with head and neck cancer were included in the study. Fifty-one healthy subjects, 31 men and 20 women, (aged 54.1 ± 14.7 years) years formed the control group. Antioxidant enzymes, superoxide dismutase, and catalase activities in erythrocytes were examined. Results: An increased level of antioxidant enzymes was seen in the blood samples from patients with head and neck cancer after incubation with Pd (II) complex. In the group we obtained a statistically significant result p = <0.001. Discussion: That project may contribute to the development of new, more efficient head and neck cancer treatment strategies. In our opinion, the results can be used in the future to develop a valuable prognostic marker of the disease. This is important because the initial phase of cancer is asymptomatic. The search for factors involved in pathogenesis translates into economic benefits and makes therapy more effectiveness through the reduction of treatment expenses.

Keywords

EN

antioxidant enzymes; head and neck cancer; oxidative stress; Pd (II) complexes; reactive oxygen species

• Journal: Otolaryngologia Polska
• Year: 2020
• Volume: 74(1)
• Pages: 23-28

Dates

published

2019-08-02

Contributors

author

Katarzyna Malinowska

author

Dariusz Kaczmarczyk

author

Radosław Zajdel

author

Anna Merecz-Sadowska

author

Jurek Olszewski

author

Małgorzata Majczyk

author

Alicja Nowak-Zduńczyk

author

Hanna Zielińska-Bliźniewska

Identifiers

DOI

10.5604/01.3001.0013.3216