An association of the MCP-1 and CCR2 single nucleotide polymorphisms with colorectal cancer prevalence

• Authors: Anna Walczak , Karolina Przybyłowska-Sygut , Andrzej Sygut , Adrianna Cieślak , Michał Mik , Łukasz Dziki , Adam Dziki , Ireneusz Majsterek

Abstracts

EN

The aim of the study: We evaluated the connection between the presence of the -2518 A/G MCP-1 as well as 190 G/A CCR2 polymorphic variants and colorectal cancer (CRC) occurrence. Material and methods: Study group consisted of subjects with different stages of CRC as well as healthy controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: W observed an association between the colorectal cancer and the GG genotype of the -2518 A/G MCP-1 single nucleotide polymorphism. No statistically significant correlation was found between CRC and the 190 G/A CCR2 polymorphism. Conclusion: The results of this study support the hypothesis that polymorphism in the MCP-1 gene may contribute to the etiology of colorectal cancer.

Keywords

EN

colorectal cancer; MCP-1; CCR-2; single nucleotide polymorphisms

• Publisher: Index Copernicus International
• Journal: Polish Journal of Surgery
• Year: 2017
• Volume: 89(5)
• Pages: 1-5

Dates

published

2017-10-12

Contributors

author

Anna Walczak

author

Karolina Przybyłowska-Sygut

author

Andrzej Sygut

author

Adrianna Cieślak

author

Michał Mik

author

Łukasz Dziki

author

Adam Dziki

author

Ireneusz Majsterek

Identifiers

DOI

10.5604/01.3001.0010.5246