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2017 | 89(5) | 1-5
Article title

An association of the MCP-1 and CCR2 single nucleotide polymorphisms with colorectal cancer prevalence

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EN
The aim of the study: We evaluated the connection between the presence of the -2518 A/G MCP-1 as well as 190 G/A CCR2 polymorphic variants and colorectal cancer (CRC) occurrence. Material and methods: Study group consisted of subjects with different stages of CRC as well as healthy controls. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: W observed an association between the colorectal cancer and the GG genotype of the -2518 A/G MCP-1 single nucleotide polymorphism. No statistically significant correlation was found between CRC and the 190 G/A CCR2 polymorphism. Conclusion: The results of this study support the hypothesis that polymorphism in the MCP-1 gene may contribute to the etiology of colorectal cancer.
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1-5
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published
2017-10-12
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Publication order reference
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bwmeta1.element.ceon.element-8e97f0c7-da1c-379c-88d2-9f9657959298
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