New directions in molecular diagnostics and therapy of vestibular schwannomas

• Authors: Malgorzata Litwiniuk , Maria Makuszewska , Robert Bartoszewicz , Kazimierz Niemczyk

Abstracts

EN

The molecular basis for the formation and growth of vestibular schwannomas (VS) has been elucidated in the recent years. The main genetic and epigenetic aberrations, changes in gene expression and specific signaling pathways involved in pathogenesis of sporadic VS and neurofibromatosis type II (NF2) have been defined. These findings facilitated the search for prognostic markers in VS and potential targets for biological therapy. This publication summarizes the main directions of research in the field of molecular diagnostics and pharmacotherapy of VS based on biological agents.

Keywords

EN

acoustic neuroma; bevacizumab; biological treatment; microRNAs; prognostic markers; vestibular schwannoma

• Publisher: Index Copernicus International
• Journal: Polski Przegląd Otorynolaryngologiczny
• Year: 2020
• Volume: 9(4)
• Pages: 55-59

Dates

published

2021-01-04

Contributors

author

Malgorzata Litwiniuk

author

Maria Makuszewska

author

Robert Bartoszewicz

author

Kazimierz Niemczyk

Identifiers

DOI

10.5604/01.3001.0014.6321