Can urea breath test (UBT) replace rapid urea test (RUT)?

• Authors: Łukasz Nawacki , Agata Czyż , Piotr Bryk , Dorota Kozieł , Renata Stępień , Stanisław Głuszek

Abstracts

EN

Background: Helicobacter pylori (Hp) is classified by the International Agency for Research on Cancer (IARC) as a Group 1 carcinogen. Its influence on the carcinogenesis of gastric cancer has been confirmed in many research studies. The conclusion is obvious - early detection and eradication of Hp can prevent the development of the disease. Methods: The objective of the study was to analyze the clinical and practical value of Carbon-13 urea breath test (UBT) in patients hospitalized due to pain complaints in the upper abdomen and dyspeptic symptoms. Fifty patients were enrolled in the study. Each patient underwent urea breath test according to the instruction included by the producer. Thereafter, each patient included in the study group was subjected to endoscopy of the upper gastrointestinal tract with the biopsy of the mucosa to determine the urease activity with rapid urease test (RUT). Results: In the study group, 14 patients (28%) achieved a positive urease test result which was confirmed in RUT. Four (8%) patients, despite a positive breath test, did not have a positive result in urease activity test from gastric mucosa. In 2 cases (4%) despite negative result of UBT, urease activity was confirmed in gastroscopic sections. The remaining 30 patients (60%) had a negative result in both studies. Conclusions: The limited availability of the gold standard for diagnostics of upper gastrointestinal tract diseases (gastroscopy) is the basis for the search for new methods of detection of Helicobacter pylori infections. The urea breath test is a method of high sensitivity and specificity. The positive result of urea breath test may be the basis for inclusion of eradication therapy.

Keywords

EN

Helicobacter pylori; urea breath test; rapid urea test; gastric cancer

• Publisher: Index Copernicus International
• Journal: Polish Journal of Surgery
• Year: 2018
• Volume: 90(5)
• Pages: 44-48

Dates

published

2018-05-28

Contributors

author

Łukasz Nawacki

author

Agata Czyż

author

Piotr Bryk

author

Dorota Kozieł

author

Renata Stępień

author

Stanisław Głuszek

Identifiers

DOI

10.5604/01.3001.0012.0669