Multidrug-resistant strains of coagulase-negative staphylococci isolated from patients with chronic sinusitis – MDR, XDR, PDR strains

• Authors: Michał Michalik , Adrianna Podbielska-Kubera , Alfred Samet , Wiesław Konopka

Abstracts

EN

Introduction: The development of resistance to multiple antimicrobial agents in pathogenic bacteria has become a threat to public health. Multidrug-resistant strains that are particularly dangerous include MDR, XDR and PDR strains. Material and methods: Aspirate material from paranasal sinuses, obtained from patients with chronic sinusitis undergoing functional endoscopic sinus surgery (FESS) in Medical Center MML in Warsaw, was subjected to bacteriologic analysis. The isolated strains were identified to the species level and tested for antibiotic resistance. Then, minimal inhibitory concentration (MIC) was determined. R esults: The isolated strains of coagulase-negative staphylococci were resistant mainly to macrolides, aminoglycosides and tetracycline. Nine of the isolated strains exhibited multidrug-resistance. Discussion: Bacteria causing chronic sinusitis are becoming increasingly resistant to antimicrobial agents. The diagnostic process for coagulase-negative staphylococci (CNS) is often limited to the identification of species, or even genus of the bacteria. The CNS strains are considered to be non-pathogenic and they are not subject to eradication. This may lead to erroneous therapeutic decisions and, consequently, to the development of antibiotic resistance. CNS infections are classified as nosocomial and therefore, appropriate epidemiological procedures have to be followed. The authors highlight the necessity to determine MIC values for antibiotics and to introduce personalized treatment.

Keywords

EN

antibiotic resistance; chronic sinusitis; coagulase-negative staphylococci; epidemiology; nosocomial infections; virulence factors

• Journal: Otolaryngologia Polska
• Year: 2020
• Volume: 74(2)
• Pages: 36-41

Dates

published

2019-11-28

Contributors

author

Michał Michalik

author

Adrianna Podbielska-Kubera

author

Alfred Samet

author

Wiesław Konopka

Identifiers

DOI

10.5604/01.3001.0013.5258