Tissue remodelling in chronic rhinosinusitis – review of literature

• Authors: Kamil Radajewski , Małgorzata Wierzchowska , Dariusz Grzanka , Paulina Antosik , Marek Zdrenka , Paweł Burduk

Abstracts

EN

CRS is a process involving a number of adverse changes in the mucosa of the paranasal sinuses and nasal polyps, e.g. increased fibroblast proliferation, angiogenesis, increased formation of fibrous tissue (subepithelial fibrosis) and tissue destruction. There are biomarkers whose levels can be increased in chronic inflammation of the paranasal sinuses: peripheral blood eosinophilia, IgE immunoglobulin, cytokines – IL-4, IL-5, IL-13, IL-25, IL-33, periostin, P-glycoprotein, CXCL-12, CXCL-13, INF-Υ, TNFα, TGFβ1, albumins, eotaxin. These biomarkers are not pathognomonic for CRS. The concentration of biomarkers is also increased in bronchial asthma and atopic dermatitis. The TGFβ, in particular the β1 subunit, was identified as the main factor involved in the remodelling of tissue stroma. In conjunction with continuous improvement of tissue testing methods, it is advisable to search for new factors that will more accurately allow the assessment of tissue remodelling in the chronic processes of paranasal sinuses.

Keywords

EN

chronic rhinosinusitis; nasal polyps; tissue remodeling

• Journal: Otolaryngologia Polska
• Year: 2019
• Volume: 73(5)
• Pages: 1-4

Dates

published

2019-09-02

Contributors

author

Kamil Radajewski

author

Małgorzata Wierzchowska

author

Dariusz Grzanka

author

Paulina Antosik

author

Marek Zdrenka

author

Paweł Burduk

Identifiers

DOI

10.5604/01.3001.0013.4121