The -2518 A/G MCP-1 polymorphism as a risk factor of inflammatory bowel disease

• Authors: Anna Walczak , Karolina Przybyłowska , Andrzej Sygut , Łukasz Dziki , Cezary Chojnacki , Jan Chojnacki , Adam Dziki , Ireneusz Majsterek

Abstracts

EN

Inflammatory bowel diseases (IBD) are disorders originated from immune disturbances. The aim of the study was to evaluate the association between the -2518 A/G MCP-1 polymorphism and the risk of IBD development. Material and methods. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Study group consisted of 197 subjects with IBD (120 with ulcerative colitis and 77 with Crohn’s disease) as well as 210 healthy controls. Results. The presence of the -2518 G/G MCP-1 genotype in the investigated groups seems to be connected with higher risk of inflammatory bowel disease as well as Crohn’s disease only (OR 2.26; 95% CI 1.44-3.54 and OR 2.08; 95% CI 1.21-3.46, respectively). Conclusions. Our data showed that the -2518 A/G MCP-1 polymorphism might be associated with the IBD occurrence and might be used as predictive factor of these diseases in a Polish population.

Keywords

EN

single nucleotide polymorphism; MCP-1 gene; inflammatory bowel disease

• Publisher: Index Copernicus International
• Journal: Polish Journal of Surgery
• Year: 2012
• Volume: 84(5)
• Pages: 238-241

Contributors

author

Anna Walczak

author

Karolina Przybyłowska

author

Andrzej Sygut

author

Łukasz Dziki

author

Cezary Chojnacki

author

Jan Chojnacki

author

Adam Dziki

author

Ireneusz Majsterek

Identifiers

DOI

10.2478/v10035-012-0039-7