Neutrophil-lymphocyte ratio and creatinine reduction ratio predict good early graft function among adult cadaveric donor renal transplant recipients. Single institution series

• Authors: Piotr Hogendorf , Anna Suska , Aleksander Skulimowski , Joanna Rut , Monika Grochowska , Aleksandra Wencel , Filip Dziwisz , Michał Nowicki , Dariusz Szymański , Grażyna Poznańska , Adam Durczyński , Janusz Strzelczyk

Abstracts

EN

The Background Delayed graft function (DGF) is a common complication following kidney transplantation and is associated with ischemia-reperfusion injury (IRI). Lymphocytes contribute to the pathogenesis of IRI and ischemia-reperfusion related to delayed graft function. Materials and Methods : 135 Caucasian patients received a kidney graft from deceased heart-beating organ donors. We divided patients into 2 groups - patients with the eGFR>=30 on the 21st day post-transplantation (n=36) and patients with the eGFR<30 on the 21st day post-transplantation (n=99) to assess kidney graft function. We measured serum creatinine levels on 1st and 2nd post-transplant day and preoperative levels of monocytes, lymphocytes, platelets, and neutrophils and their ratios. Results: We have found statistically significant differences between the eGFR<30 and the eGFR>=30 groups in the average lnLymphocytes (0.36 +/-0.6 vs. -0.016 +/-0.74, respectively p=0.004) lnNLR (1,27 +/-0.92 vs. 1.73+/-1.08 p=0.016) lnLMR (1.01 +/-0.57 vs. 0.73 +/-0.64 p=0.02), lnPLR (4.97 +/-0.55 vs. 5.26 +/- 0.67 p=0.023), and CCR 2% (-20.20 +/- 21.55 vs. -4.29 +/- 29.62 p=0.004. In the univariate analysis, factors of lnLymphocytes >=0.22 (OR=0.331 95%CI 0.151-0.728 p=0.006), lnLMR>=1.4 (OR=0.255 95%CI 0.072-0.903 p=0.034) were associated with a worse graft function, while lnNLR>=1.05 (OR=2.653 95%CI 1.158-6,078 p=0.021), lnPLR>=5.15 (OR=2.536 95%CI 1.155-5.566 p=0.02) and CRR2 (OR=3.286 95% CI 1.359-7.944 p=0.008) indicated a better graft function. Conclusion: A higher absolute lymphocyte count (lnLymphocytes) and lnLMR, as well as lower lnNLR and lnPLR were associated with a lower eGFR on the 21st day after kidney transplantation. In the multivariate analysis, CRR2 in combination with either lnLymphocytes, lnNLR or lnPLR improved the accuracy of detecting patients with poor graft function.

Keywords

EN

neutrophil-lymphocyte ratio; creatinine reduction ratio; graft function; cadaveric donor; delayed graft function kidney transplant

• Journal: Polish Journal of Surgery
• Year: 2018
• Volume: 90(2)
• Pages: 28-33

Dates

published

2018-04-11

Contributors

author

Piotr Hogendorf

author

Anna Suska

author

Aleksander Skulimowski

author

Joanna Rut

author

Monika Grochowska

author

Aleksandra Wencel

author

Filip Dziwisz

author

Michał Nowicki

author

Dariusz Szymański

author

Grażyna Poznańska

author

Adam Durczyński

author

Janusz Strzelczyk

Identifiers

DOI

10.5604/01.3001.0011.7499