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Journal
2018 | 67 | 1 | 43-55
Article title

Modyfikacje potranslacyjne aktyny

Authors
Content
Title variants
EN
Posttranslational modifications of actin
Languages of publication
PL EN
Abstracts
PL
Aktyna, komponent cytoszkieletu komórek eukariotycznych, to jedno z białek najistotniejszych dla funkcjonowania organizmów i najlepiej zachowanych w toku ewolucji. Ta globularna cząsteczka o masie cząsteczkowej około 42,3 kDa występuje zarówno w formie monomerycznej, jak i spolimeryzowanej (filamenty), a zdolność do dynamicznej reorganizacji aktyny jest niezbędna dla życia komórki. Przejście pomiędzy obiema formami jest możliwe dzięki precyzyjnej w czasie i przestrzeni, dynamicznej regulacji organizacji aktyny przez szereg białek wiążących się zarówno z monomerami, jak i filamentami aktyny. Istotnym czynnikiem wpływającym na stopień spolimeryzowania aktyny są także liczne modyfikacje potranslacyjne tego białka. Niniejszy artykuł przeglądowy jest poświęcony omówieniu tego obszernego i wciąż mało poznanego zagadnienia, a w szczególności opisowi jakim modyfikacjom ulega aktyna i w jaki sposób modyfikacje te wpływają na strukturę i funkcje tego wyjątkowego białka.
EN
Actin, a constituent of the cytoskeleton of eukaryotic cells, is one of the most important as well as best evolutionary conserved proteins. This globular protein with molecular mass of ~42.3 kDa exists in the cell both in the monomeric and filamentous form, and ability to undergo dynamic reorganization of these two forms is absolutely crucial for cell survival. The monomer-filament transition, precisely controlled in time and space, is possible due to interaction of actin with a panoply of proteins binding to either monomeric or filamentous actin. Yet another factor is affecting actin organization, namely numerous posttranslational modifications. This review article is devoted to presentation of this broad and still unrecognized topic with emphasis on description of the type of actin modifications and how they affect actin structure and function.
Keywords
Journal
Year
Volume
67
Issue
1
Pages
43-55
Physical description
Dates
published
2018
Contributors
  • Pracownia Molekularnych Podstaw Ruchów Komórkowych, Zakład Biochemii, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Pasteura 3, 02-093 Warszawa, Polska
  • Laboratory of Molecular Basis of Cell Motility, Department of Biochemistry, Nencki Institute of Experimental Biology PAS, 3 Pasteur Str., 02-093 Warsaw,, Poland
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Publication order reference
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bwmeta1.element.bwnjournal-article-ksv67p43kz
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