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2018 | 67 | 2 | 397-407
Article title

Apelina nowym regulatorem funkcji komórek jajnika

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EN
Apelin as a new regulator of ovarian cells function
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PL EN
Abstracts
PL
Tkanka tłuszczowa pełni aktywną funkcję wydzielniczą i uznana jest za największy gruczoł endokrynny organizmu. Adipocyty produkują i wydzielają do krwiobiegu szereg hormonów białkowych zwanych adipokinami, m.in apelinę. Hormon ten jest znanym endogennym ligandem dla receptora APJ. Ekspresję zarówno apeliny jak i jej receptora APJ wykazano w wielu tkankach, takich jak: żołądek, mózg, serce, płuca, macica czy jądra. Rolę apeliny opisano w licznych procesach fizjologicznych, jak również w patofizjologii niektórych chorób metabolicznych. Badania ostatnich lat sugerują, iż apelina reguluje również funkcje rozrodcze samic. W artykule przedstawiono aktualny stan wiedzy na temat poziomu apeliny/APJ w komórkach jajnika zarówno człowieka, jak i wielu gatunków zwierząt, a także opisano jej rolę w regulacji funkcji pęcherzyka jajnikowego i ciałka żółtego. Omówione prace jednoznacznie wskazują, na zależną od badanego gatunku ekspresję apeliny/APJ w różnych strukturach jajnika oraz rolę apeliny w procesie steroidogenezy czy apoptozy, sugerując iż jajnik jest docelową tkanką działania apeliny.
EN
Adipose tissue plays an active secretory function and is considered as the largest endocrine gland of the body. Adipocytes produce and secrete into the bloodstream a number of protein hormones called adipokines, such as apelin. This hormone is a known endogenous ligand for APJ receptor. The expression of both apelin and the APJ receptor has been demonstrated in many tissues such as stomach, brain, heart, lung, uterus or testis. The role of apelin has been described in numerous physiological processes in the body, as well as in the pathophysiology of certain metabolic diseases. Recent studies suggest that apelin also regulates female reproductive functions. The article presents the actual state of knowledge on the level of apelin/APJ in the ovarian cells of both the humans and many animal species, as well as the role of apelin in regulation the ovarian follicle and corpus luteum functions. The presented data clearly indicates, dependent on the species expression of apelin/APJ in various structures of ovary and the role of apelin in steroidogenesis and apoptosis, suggesting that ovary is the target tissue for apelin action.
Journal
Year
Volume
67
Issue
2
Pages
397-407
Physical description
Dates
published
2018
Contributors
author
  • Zakład Fizjologii i Toksykologii Rozrodu, Instytut Zoologii i Badań Biomedycznych, Uniwersytet Jagielloński w Krakowie, Gronostajowa 9, 30-387 Kraków, Polska
  • Department of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, Gronostajowa 9, 30-387 Kraków, Poland
  • Zakład Fizjologii i Toksykologii Rozrodu, Instytut Zoologii i Badań Biomedycznych, Uniwersytet Jagielloński w Krakowie, Gronostajowa 9, 30-387 Kraków, Polska
  • Department of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, Gronostajowa 9, 30-387 Kraków, Poland
author
  • Zakład Fizjologii i Toksykologii Rozrodu, Instytut Zoologii i Badań Biomedycznych, Uniwersytet Jagielloński w Krakowie, Gronostajowa 9, 30-387 Kraków, Polska
  • Department of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, Gronostajowa 9, 30-387 Kraków, Poland
  • Zakład Fizjologii i Toksykologii Rozrodu, Instytut Zoologii i Badań Biomedycznych, Uniwersytet Jagielloński w Krakowie, Gronostajowa 9, 30-387 Kraków, Polska
  • Department of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, Gronostajowa 9, 30-387 Kraków, Poland
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bwmeta1.element.bwnjournal-article-ksv67p397kz
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