Budowa ciałka podstawowgo i centrioli

• Authors: Ewa Joachimiak

Title variants

EN

Structure of basal body and centriole

• Languages of publication: PL EN

Abstracts

PL

Ciałko podstawowe i centriola to struktury homologiczne, których zrąb stanowi dziewięć mikrotubularnych tripletów. Mikrotubulom ciałka podstawowego/centrioli towarzyszą liczne struktury mikrotubularne i niemikrotubularne. Ich obecność nie tylko powoduje polaryzację ciałka podstawowego i centrioli, lecz także umożliwia ich prawidłowe funkcjonowanie. Przypuszcza się, że ciałka podstawowe występowały już u ostatniego wspólnego przodka eukariontów, tzw. LECA, a ich budowa i funkcja okazały się tak wydajne, że nie zmieniły się znacząco w toku ewolucji. Ciałka podstawowe i centriole odgrywają istotną rolę w komórce, a zaburzenia ich liczby, struktury lub lokalizacji obserwuje się m.in. w licznych nowotworach, chorobach układu nerwowego czy złożonych zespołach wieloobjawowych zwanych ciliopatiami.

EN

Basal body and centriole are homologous structures, build of nine triplet microtubules. The basal body/centriole microtubular scaffold is accompanied by numerous structures both microtubular and non-microtubular, which not only cause basal body/centriole polarization but also allow its proper functioning. It is assumed that basal bodies were present in last common eukaryotic ancestor, so-called LECA, and their structure and function appeared such efficient, that they did not change significantly in evolution.
Basal bodies and centrioles play an important role in the cell and the abnormalities in their number, structure or location are observed in numerous cancers, neuropathies and ciliopathies.

Keywords

PL

centriola; ciałko podstawowe; triplet

EN

basal body; centriole; triplet

• Journal: Kosmos
• Year: 2018
• Volume: 67
• Issue: 1
• Pages: 151-162

Dates

published

2018

Contributors

author

Ewa Joachimiak

• Pracownia Cytoszkieletu i Biologii Rzęsek, Zakład Biologii Komórki, Instytut Biologii Doświadczalnej im. M. Nenckiego, PAN, Pasteura 3, Warszawa, Polska
• Laboratory of Cytoskeleton and Cilia Biology, Department of Cell Biology, Nencki Institute of Experimental Biology PAS, 3 Pasteur Str., 02-093 Warsaw, Poland

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