Białko cacybp/sip i jego rola w organizacji cytoszkieletu

• Authors: Anna Filipek , Agnieszka Góral

Title variants

EN

Cacybp/sip protein and its role in cytoskeleton organization

• Languages of publication: PL EN

Abstracts

PL

Białko CacyBP/SIP występuje w różnych komórkach i tkankach ssaków, a jego wysoki poziom notowany jest w mózgu, śledzionie, grasicy oraz w wielu nowotworach. CacyBP/SIP oddziałuje z wieloma białkami efektorowymi, w tym z białkami cytoszkieletu: aktyną, tubuliną, tropomiozyną. Wskazuje to, iż CacyBP/SIP bierze udział w procesach komórkowych, którym towarzyszą zmiany w organizacji cytoszkieletu zarówno w warunkach fizjologicznych jak też w różnych stanach chorobowych. W niniejszej pracy przedstawiono charakterystykę oddziaływania CacyBP/SIP z białkami cytoszkieletu oraz rolę tych interakcji w różnych procesach komórkowych.

EN

The CacyBP/SIP protein is present in different mammalian cells and tissues. Its particularly high level is observed in brain, spleen, thymus and in many cancers. CacyBP/SIP interacts with different targets including cytoskeletal proteins such as tubulin, actin, tropomyosin. This indicates that CacyBP/SIP is involved in cellular processes associated with changes in cytoskeleton organization under physiology and pathology. In the present work the characteristics of complexes formed between CacyBP/SIP and cytoskeletal proteins and the role of those interactions are presented.

Keywords

PL

białka efektorowe; CacyBP/SIP; cytoszkielet; neurodegeneracja; nowotwory; proliferacja; różnicowanie

EN

CacyBP/SIP; cancers; cytoskeleton; differentiation; proliferation; neurodegeneration; target proteins

• Journal: Kosmos
• Year: 2018
• Volume: 67
• Issue: 1
• Pages: 131-137

Dates

published

2018

Contributors

author

Anna Filipek

• Pracownia Białek Wiążących Wapń, Zakład Neurobiologii Molekularnej i Komórkowej, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Pasteura 3, 02-093 Warszawa, Polska
• Laboratory of Calcium Binding Proteins, Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology PAS, 3 Pasteur Str., 02-093 Warsaw, Poland

author

Agnieszka Góral

• Pracownia Białek Wiążących Wapń, Zakład Neurobiologii Molekularnej i Komórkowej, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Pasteura 3, 02-093 Warszawa, Polska
• Laboratory of Calcium Binding Proteins, Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology PAS, 3 Pasteur Str., 02-093 Warsaw, Poland

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