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Journal
2017 | 66 | 1 | 93-107
Article title

Nowe strategie walki z chorobami zakaźnymi - leki skierowane przeciwko czynnikom wirulencji

Content
Title variants
EN
New strategies to combat infecious diseases - antivirulence drugs.
Languages of publication
PL EN
Abstracts
PL
Stale rosnąca liczba szczepów bakterii patogennych opornych na stosowane w terapiach ludzi antybiotyki stanowi zagrożenie dla ludzkości. Zgodnie z danymi Europejskiego Centrum ds. Zapobiegania i Kontroli Chorób tylko w Europie odnotowywanych jest rocznie około 25.000 zgonów z powodu chorób będącymi konsekwencją infekcji powodowanych przez mikroorganizmy oporne na antybiotyki. Pomiędzy rokiem 1930 a 1962 zidentyfikowano i wprowadzono do terapii ponad 20 klas antybiotyków. Od tego czasu zarejestrowano tylko dwie nowe klasy antybiotyków. Skuteczna walka z chorobami zakaźnymi wymaga opracowania i wprowadzenia na rynek nowych klas leków o odmiennych od antybiotyków mechanizmach działania. Praca przeglądowa prezentuje najnowsze osiągnięcia dotyczące identyfikacji nowej klasy leków antybakteryjnych, tzw. leków blokujących procesy wirulencji. Omówione są zarówno leki blokujące konkretne czynniki wirulencji, jak i te, których celem działania są globalne procesy zachodzące w komórkach, istotne także dla procesów patogenezy.
EN
The rapid emergence of resistant bacteria occurring in many parts of the world constitutes an increasing risk to public health. According to European Centre for Disease Prevention and Control (ECDC), in 2009 infections caused by a subset of resistant bacteria were responsible for about 25 000 deaths in Europe. The issue of resistance concerns both gram-positive and gram-negative pathogens that cause infections in the hospitals and in the community. The success in combat against infectious diseases depends upon development of effective anti-infective drugs. More than 20 novel classes of antibiotics were introduced into market between 1930 and 1962. Since then only two new classes of antibiotics have been approved for clinical use. This review presents recent advances toward the development of alternative medicines to classical antibiotics, antivirulence drugs, and highlights their benefits and disadvantages over conventional antibacterials. There are described both potential drugs aimed at single targets as well as those able to inhibit global cellular processes essential for virulence.
Journal
Year
Volume
66
Issue
1
Pages
93-107
Physical description
Dates
published
2017
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bwmeta1.element.bwnjournal-article-ksv66p93kz
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