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Journal
2017 | 66 | 4 | 553-562
Article title

Receptory związane z białkami G w odporności wrodzonej bezkręgowców

Content
Title variants
EN
G-protein-coupled receptors in invertebrate innate immunity
Languages of publication
PL EN
Abstracts
PL
Receptory związane z białkami G (GPCRs) stanowią najliczniejszą i bardzo zróżnicowaną grupę receptorów błonowych odpowiedzialnych za przekazywanie sygnałów ze środowiska zewnętrznego do wnętrza komórki. GPCRs uczestniczą niemal w każdym aspekcie życia organizmów, regulując m. in. mechanizmy związane z odpowiedzią immunologiczną, zarówno u kręgowców, jak i bezkręgowców. W pracy opisano ogólną budowę i klasyfikację GPCRs, mechanizmy aktywacji i przekazywania sygnału przez te receptory oraz sposoby regulacji ich aktywności. Ponadto zamieszczono podstawowe informacje na temat mechanizmów rozpoznawania patogenów przez bezkręgowce. W zasadniczej części pracy zaprezentowano wyniki najnowszych badań dotyczące zaangażowania GPCRs w reakcje obronne bezkręgowców, na przykładzie wybranych organizmów modelowych, tj. skrzypłocza atlantyckiego (Limulus polyphemus), muszki owocowej (Drosophila melanogaster) oraz nicienia (Caenorhabditis elegans).
EN
The G-protein-coupled receptors (GPCRs) form the largest and most diverse group of membrane receptors engaged in extracellular signals transduction. GPCRs are involved in almost all aspects of vertebrates and invertebrates' life, including regulation of the immune response mechanisms. The paper describes the general structure and classification of GPCRs. Moreover, it presents the mechanisms of GPCR activation and signal transduction as well as the regulation of GPCR activity. Furthermore, basic information about the mechanisms of pathogen recognition by invertebrates is included. The main part of this review shows the most recent data about the involvement of GPCRs in defense mechanisms of invertebrates such as the horseshoe crab (Limulus polyphemus), fruit fly (Drosophila melanogaster), and nematode (Caenorhabditis elegans).
Journal
Year
Volume
66
Issue
4
Pages
553-562
Physical description
Dates
published
2017
Contributors
  • Zakład Immunobiologii, Instytut Biologii i Biochemii, Wydział Biologii i Biotechnologii UMCS, Akademicka 19, 20-033 Lublin, Polska
  • Department of Immunobiology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland
  • Zakład Wirusologii i Immunologii, Instytut Mikrobiologii i Biotechnologii, Wydział Biologii i Biotechnologii UMCS, Akademicka 19, 20-033 Lublin, Polska
  • Department of Virology and Immunology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland
  • Zakład Wirusologii i Immunologii, Instytut Mikrobiologii i Biotechnologii, Wydział Biologii i Biotechnologii UMCS, Akademicka 19, 20-033 Lublin, Polska
  • Department of Virology and Immunology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-ksv66p553kz
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