Receptory związane z białkami G w odporności wrodzonej bezkręgowców

• Authors: Mariola Andrejko , Magdalena Mizerska-Kowalska , Barbara Zdzisińska

Title variants

EN

G-protein-coupled receptors in invertebrate innate immunity

• Languages of publication: PL EN

Abstracts

PL

Receptory związane z białkami G (GPCRs) stanowią najliczniejszą i bardzo zróżnicowaną grupę receptorów błonowych odpowiedzialnych za przekazywanie sygnałów ze środowiska zewnętrznego do wnętrza komórki. GPCRs uczestniczą niemal w każdym aspekcie życia organizmów, regulując m. in. mechanizmy związane z odpowiedzią immunologiczną, zarówno u kręgowców, jak i bezkręgowców. W pracy opisano ogólną budowę i klasyfikację GPCRs, mechanizmy aktywacji i przekazywania sygnału przez te receptory oraz sposoby regulacji ich aktywności. Ponadto zamieszczono podstawowe informacje na temat mechanizmów rozpoznawania patogenów przez bezkręgowce. W zasadniczej części pracy zaprezentowano wyniki najnowszych badań dotyczące zaangażowania GPCRs w reakcje obronne bezkręgowców, na przykładzie wybranych organizmów modelowych, tj. skrzypłocza atlantyckiego (Limulus polyphemus), muszki owocowej (Drosophila melanogaster) oraz nicienia (Caenorhabditis elegans).

EN

The G-protein-coupled receptors (GPCRs) form the largest and most diverse group of membrane receptors engaged in extracellular signals transduction. GPCRs are involved in almost all aspects of vertebrates and invertebrates' life, including regulation of the immune response mechanisms. The paper describes the general structure and classification of GPCRs. Moreover, it presents the mechanisms of GPCR activation and signal transduction as well as the regulation of GPCR activity. Furthermore, basic information about the mechanisms of pathogen recognition by invertebrates is included. The main part of this review shows the most recent data about the involvement of GPCRs in defense mechanisms of invertebrates such as the horseshoe crab (Limulus polyphemus), fruit fly (Drosophila melanogaster), and nematode (Caenorhabditis elegans).

Keywords

PL

bezkręgowce; odporność wrodzona; receptory związane z białkami G (GPCRs)

EN

G-protein-coupled receptors (GPCRs); innate immunity; invertebrate

• Journal: Kosmos
• Year: 2017
• Volume: 66
• Issue: 4
• Pages: 553-562

Dates

published

2017

Contributors

author

Mariola Andrejko

• Zakład Immunobiologii, Instytut Biologii i Biochemii, Wydział Biologii i Biotechnologii UMCS, Akademicka 19, 20-033 Lublin, Polska
• Department of Immunobiology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland

author

Magdalena Mizerska-Kowalska

• Zakład Wirusologii i Immunologii, Instytut Mikrobiologii i Biotechnologii, Wydział Biologii i Biotechnologii UMCS, Akademicka 19, 20-033 Lublin, Polska
• Department of Virology and Immunology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland

author

Barbara Zdzisińska

• Zakład Wirusologii i Immunologii, Instytut Mikrobiologii i Biotechnologii, Wydział Biologii i Biotechnologii UMCS, Akademicka 19, 20-033 Lublin, Polska
• Department of Virology and Immunology, Maria Curie-Sklodowska University, Akademicka 19, 20-033 Lublin, Poland

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