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2017 | 66 | 3 | 475-485
Article title

Molekularny mechanizm endoreduplikacji u roślin wyższych

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Title variants
EN
Molecular mechanism of endoreduplication in higher plants
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PL EN
Abstracts
PL
Proces endoreduplikacji stanowi alternatywną formę cyklu komórkowego, podczas której następuje amplifikacja jądrowego DNA, po której nie zachodzi jednak mitoza i podział komórki. Mechanizm molekularny tego procesu w dużej mierze opiera się na białkach uczestniczących w typowym cyklu komórkowym i polega na zablokowaniu mitozy wraz z ponownym zainicjowaniem replikacji DNA. W endoreduplikacji ważną rolę odgrywają kinazy zależne od cyklin oraz ich białka regulatorowe - cykliny. Podczas tego procesu aktywność tych białek jest regulowana na poziomie transkrypcyjnym i potranslacyjnym. Zmiana aktywności kinaz zależnych od cyklin może wynikać ze zmniejszenia dostępności cyklin w wyniku zablokowania ich transkrypcji oraz ze zmian statusu fosforylacji kinaz zależnych od cyklin. Może być również negatywnie regulowana poprzez fosforylację podjednostki kinazy zależnej od cyklin przez kinazę WEE1 oraz poprzez interakcję z inhibitorami kinaz zależnych od cyklin. Regulacja na poziomie potranslacyjnym polega natomiast na ukierunkowanej destrukcji cyklin przez kompleks promujący anafazę/cyklosom. Szczegółowe omówienie mechanizmów molekularnych tego procesu zostało przedstawione w poniższym artykule.
EN
Endoreduplication represents an alternative form of the cell cycle in which nuclear DNA amplification occurs, but it is not followed by mitosis and cell division. The molecular mechanism of this process is largely based on proteins involved in typical cell cycle and involves block of mitosis and re-initiation of DNA replication. Cyclin-dependent kinases and theirs regulatory proteins - cyclins are the key components of endoreduplication. During the process, activity of these proteins is regulated at the transcriptional and post-translational levels. Changes in the activity of cyclin dependent kinases may be due to a reduced availability of cyclins resulting from blocking of respective genes transcription and to changes in the status of cyclin-dependent phosphorylation of kinases. It can be also negatively regulated by phosphorylation of the cyclin-dependent kinase subunit by kinase WEE1, and by interaction with inhibitors of cyclin dependent kinases. Post-translational regulation occurs via targeted destruction of cyclins by the anaphase promoting complex/cyclosome. A detailed discussion of the molecular mechanism of these processes is presented in this article.
Journal
Year
Volume
66
Issue
3
Pages
475-485
Physical description
Dates
published
2017
Contributors
author
  • Zakład Biologii Molekularnej i Cytometrii, Katedra Genetyki, Fizjologii i Biotechnologii Roślin, Uniwersytet Technologiczno-Przyrodniczy, im. Jana i Jędrzeja Śniadeckich w Bydgoszczy, Al. Prof. S. Kaliskiego 7, 85-796 Bydgoszcz, Polska
  • Laboratory of Molecular Biology and Cytometry, Department of Plant Genetics, Physiology and Biotechnology, UTP University of Science and Technology, Kaliskiego Ave. 7, 85-796 Bydgoszcz, Poland
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bwmeta1.element.bwnjournal-article-ksv66p475kz
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