Rola witaminy D₃ i jej receptora w żeńskim układzie rozrodczym

• Authors: Monika Herian , Małgorzata Grzesiak

Title variants

EN

The role of vitamin D₃ and its receptor in the female reproductive system

• Languages of publication: PL EN

Abstracts

PL

Badania ostatnich lat sugerują pogłębiający się problem niedoboru witaminy D3. Oprócz dobrze poznanej roli witaminy D3 w utrzymaniu homeostazy wapniowo-fosforanowej, coraz większym zainteresowaniem cieszy się jej udział w regulacji funkcji żeńskiego układu rozrodczego. Występowanie receptora witaminy D3 w jajnikach, endometrium macicy oraz łożysku świadczy, że są to tkanki docelowe dla tej witaminy. Liczne badania potwierdzają, iż obniżony poziom aktywnych form witaminy D3 sprzyja zaburzeniom budowy i funkcji jajnika oraz macicy. Dotychczas zaobserwowano istotną rolę kalcytriolu w procesach folikulogenezy, steroidogenezy, implantacji zarodka, przebiegu ciąży oraz utrzymaniu zdrowia potomstwa. Obniżony poziom witaminy D3 sprzyja patologiom żeńskiego układu rozrodczego, tj. zespół policystycznych jajników, przedwczesna niewydolność jajników, endometrioza czy mięśniaki macicy. Ekspozycja na promieniowanie słoneczne i zbilansowana dieta, pozwalają na utrzymanie prawidłowego stężenia kalcydiolu w surowicy krwi. Poszerzenie wiedzy na temat roli witaminy D3 w patogenezie schorzeń żeńskiego układu rozrodczego, może przyczynić się do wykorzystania jej suplementacji jako skutecznego sposobu profilaktyki i leczenia.

EN

Recent studies suggested an increasing problem with deficiency of vitamin D3. Except for the well-known role of vitamin D3 in the maintenance of calcium and phosphate homeostasis, its contribution to the regulation of the female reproduction becomes more popular. The presence of vitamin D3 receptor in the ovary, endometrium and placenta indicates that these tissues are target for vitamin D3 action. Many studies confirm that low level of active vitamin D3 promotes the occurrence of abnormalities in the structure and function of the ovary and uterus. To date, a significant role of calcitriol in folliculogenesis, steroidogenesis, embryo implantation, pregnancy and the offspring health has been observed. Decreased level of vitamin D3 associated with many pathologies in the female reproductive system such as polycystic ovarian syndrome, premature ovarian failure, endometriosis or uterine fibroids. Exposure to sunlight and balanced diet help to maintain normal levels of calcidiol in blood serum. Increasing knowledge about the role of vitamin D3 in female reproductive pathogenesis may contribute to the use of adequate vitamin D3 supplementation as an effective tool in the preventive and therapeutic treatment.

Keywords

PL

jajnik; macica; PCOS; receptor witaminy D₃; witamina D₃

EN

ovary; PCOS; receptor; uterus; vitamin D₃

• Journal: Kosmos
• Year: 2017
• Volume: 66
• Issue: 3
• Pages: 389-399

Dates

published

2017

Contributors

author

Monika Herian

• Katedra Fizjologii i Endokrynologii Zwierząt, Wydział Hodowli i Biologii Zwierząt, Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie, Al. Mickiewicza 24/28, 30-059 Kraków, Polska
• Department of Animal Physiology and Endocrinology, Faculty of Animal Sciences University of Agriculture in Krakow, Al. Mickiewicza 24/28, 30-059 Krakow, Poland

author

Małgorzata Grzesiak

• Katedra Fizjologii i Endokrynologii Zwierząt, Wydział Hodowli i Biologii Zwierząt, Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie, Al. Mickiewicza 24/28, 30-059 Kraków, Polska
• Ośrodek Medycyny Eksperymentalnej i Innowacyjnej, Uniwersyteckie Centrum Medycyny Weterynaryjnej UJ-UR, ul. Rędzina 1C, 30-248 Kraków, Polska
• Department of Animal Physiology and Endocrinology, Faculty of Animal Sciences University of Agriculture in Krakow, Al. Mickiewicza 24/28, 30-059 Krakow, Poland
• Center of Experimental and Innovative Medicine, University Center of Veterinary Medicine JU-AU, Rędzina 1C, 30-248 Krakow, Poland

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