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2017 | 66 | 1 | 31-40
Article title

Prątki niegruźlicze - dlaczego tak trudno leczyć mykobakteriozy?

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EN
Nontuberculous mycobacteria - why treatment is so difficult?
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PL EN
Abstracts
PL
Zakażenia prątkami niegruźliczymi stanowią w dzisiejszych czasach znaczący problem. Infekcje te dotyczą najczęściej osób z obniżoną odpornością. Atypowe prątki są często przyczyną mykobakteriozy płucnej, ale także pozapłucnej, w przypadkach kiedy infekcja rozwija się w obrębie skóry, tkanek miękkich czy kości. Nowoczesna diagnostyka wykorzystująca narzędzia biologii molekularnej pozwala na szybką identyfikację gatunku MOTT, jednakże wykrycie atypowych prątków nie zawsze świadczy o mykobakteriozie i konieczności terapii, która ze względu na liczne mechanizmy oporności MOTT może okazać się nieskuteczna. Interesującym zjawiskiem jest także zdolność prątków atypowych do tworzenia biofilmów, trójwymiarowych struktur wielokrotnie zmniejszających wrażliwość tych drobnoustrojów na antybiotyki.
EN
Nontuberculous mycobacteria (NTM) is a group of opportunistic species of mycobacteria other than Mycobacterium tuberculosis complex and Mycobacterium leprae, which are widespread in the environment occurring in soil, water and dust. Therefore, it is common to localize them in the respiratory, gastrointestinal tract and skin. In the past two decades, increasing number of infections caused by atypical mycobacteria was reported worldwide. Development of molecular biology and new diagnostic tests enables faster distinction of atypical mycobacteria from Mycobacterium tuberculosis complex and more accurate identification of the species. Most atypical mycobacteria are naturally resistant to antibiotics commonly used for treatment of both mycobacteriosis and tuberculosis. The drug resistance of NTM involves nonspecific mechanisms, which also occur in other bacteria, and specific mechanisms characteristic for mycobacteria only. Resistance can be innate, determined by the bacterial genome, or acquired, as the result of mutational changes.
Journal
Year
Volume
66
Issue
1
Pages
31-40
Physical description
Dates
published
2017
Contributors
  • Pracownia Genetyki i Fizjologii Mycobacterium, Instytut Biologii Medycznej PAN, Lodowa 106, 93-232 Łódź, Polska
  • Laboratory of Mycobacterium Genetics and Physiology, Institute of Medical Biology PAS, Lodowa 106, 93-232 Łódź, Poland
  • Pracownia Genetyki i Fizjologii Mycobacterium, Instytut Biologii Medycznej PAN, Lodowa 106, 93-232 Łódź, Polska
  • Laboratory of Mycobacterium Genetics and Physiology, Institute of Medical Biology PAS, Lodowa 106, 93-232 Łódź, Poland
  • Pracownia Genetyki i Fizjologii Mycobacterium, Instytut Biologii Medycznej PAN, Lodowa 106, 93-232 Łódź, Polska
  • Laboratory of Mycobacterium Genetics and Physiology, Institute of Medical Biology PAS, Lodowa 106, 93-232 Łódź, Poland
  • Pracownia Genetyki i Fizjologii Mycobacterium, Instytut Biologii Medycznej PAN, Lodowa 106, 93-232 Łódź, Polska
  • Laboratory of Mycobacterium Genetics and Physiology, Institute of Medical Biology PAS, Lodowa 106, 93-232 Łódź, Poland
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