Charakterystyka zmian metabolicznych zachodzących w procesie starzenia się tkanki tłuszczowej

• Authors: Kinga Gwóźdź

Title variants

EN

The characteristics of metabolic changes in adipose tissue aging

• Languages of publication: PL EN

Abstracts

PL

Wraz z wiekiem wiele procesów fizjologicznych i metabolicznych zmienia się. Efektem tych zmian mogą być powstające zaburzenia w funkcjonowaniu tkanek i narządów, co w konsekwencji może prowadzić do zapoczątkowania procesów starzenia. Zaobserwowano, że w podczas starzenia się rozmieszczenie i właściwości tkanki tłuszczowej ulegają zmianom. Zmniejsza się ilość podskórnej tkanki tłuszczowej oraz obserwuje się wzrost tendencji do odkładania tłuszczu trzewnego, którego nadmiar może stanowić czynnik ryzyka rozwoju chorób metabolicznych. W starzejących się adipocytach dochodzi do zmian w rozmieszczeniu receptorów, co może mieć również związek z obniżeniem wrażliwości na działanie hormonów, ponadto obserwuje się zmiany w ekspresji genów, długości telomerów i aktywności enzymów uczestniczących w metabolizmie lipidów. Aktywność wydzielnicza tkanki tłuszczowej zmienia się z wiekiem, ponadto podczas starzenia dochodzi do rozwoju wielu zaburzeń w metabolizmie komórek tłuszczowych. Całokształt zmian prowadzi do obniżenia wydajności metabolicznej komórek i całej tkanki, co może mieć ogromny wpływ na stan zdrowia i pozostawać w związku z rozwojem chorób metabolicznych oraz chorób związanych z wiekiem.

EN

With the increasing age of organisms there are observed numerous changes in their metabolic and physiological processes. These changes may affect functioning of various tissues and organs, leading in consequence to initiation of aging process. Aging process is also taking place in adipose tissue and is characterized by changes in fat distribution. There is observed a decrease in subcutaneous adipose tissue mass while that of visceral fat increases and may contribute to development of metabolic syndrome. In aging adipocytes there were observed alteration in receptor distribution, changes in telomere length, gene expression profile and enzyme's activity. The secretory activity of adipose tissue alters during aging. All these changes lead to reduction of the metabolic capacity of adipocytes and of the whole tissue, which may exert a significant impact on the health and may be associated with development of the age-related and metabolic diseases.

Keywords

PL

adipocyty; adipokiny; metabolizm; proces starzenia; tkanka tłuszczowa

EN

adipocytes; adipokines; adipose tissue; aging process; metabolism

• Journal: Kosmos
• Year: 2017
• Volume: 66
• Issue: 2
• Pages: 285-295

Dates

published

2017

Contributors

author

Kinga Gwóźdź

• Uniwersytet Przyrodniczy w Poznaniu, Wydział Medycyny Weterynaryjnej i Nauk o Zwierzętach, Katedra Fizjologii i Biochemii Zwierząt, Wołyńska 35, 60-637 Poznań, Polska
• Poznan University of Life Sciences, Faculty of Veterinary Medicine and Animal Sciences, Department of Animal Physiology and Biochemistry, Wolynska 35, 60-637 Poznan, Poland

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