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Journal
2016 | 65 | 3 | 351-360
Article title

Wzmożona aktywność fizyczna jako terapia wspomagająca w chorobie Parkinsona - badania u ludzi i zwierząt

Content
Title variants
EN
Increased physical training as supportive therapy in Parkinson's disease - research in humans and animals
Languages of publication
PL EN
Abstracts
PL
Choroba Parkinsona (PD) należy do zwyrodnieniowych schorzeń ośrodkowego układu nerwowego, którego podstawowym objawem są zaburzenia motoryczne, będące konsekwencją degeneracji neuronów dopaminergicznych drogi nigrostriatalnej. Złożone podłoże choroby sprawia, że jej etiologia jest nadal niewyjaśniona. Dostępne formy leczenia łagodzą jedynie objawy choroby, przy czym skuteczność ich działania maleje wraz z rozwojem choroby. Z tego względu niezwykle ważne jest poszukiwanie nowych form terapii wspomagających leczenie farmakologiczne. Celem pracy jest przedstawienie aktualnego stanu wiedzy na temat wpływu treningu fizycznego na łagodzenie objawów choroby Parkinsona. Na podstawie wyników badań przeprowadzonych u ludzi i w zwierzęcych modelach PD stwierdzono, że wzmożona aktywność fizyczna stosowana długotrwale poprawia wzorce zachowań ruchowych, oraz wzmacnia proces angiogenezy, synaptogenezy i neurogenezy w mózgu. Wpływa również na podwyższenie poziomu czynników neurotroficznych. Spośród znanych obecnie form aktywności fizycznej wspomagających łagodzenie objawów PD wymienia się przede wszystkim ćwiczenia oddechowe, chodu i równowagi, ćwiczenia wzmacniające, rozciągające, relaksacyjne, Tai Chi oraz taniec.
EN
Parkinson's Disease (PD) is a neurodegenerative disorder in which progressive deterioration of the nigro-striatal dopaminergic pathway leads to motor disturbances. The underlying etiology responsible for the pathological changes observed in PD is still unclear. Currently available treatments are only symptomatic, and their effectiveness decreases with the progression of the disease. For this reason, it is of paramount importance to search for new forms of therapy which may accompany pharmacological treatment. Therefore the aim of this paper is to present the current knowledge concerning the impact of physical activity on the reduction of PD symptoms. Based on the results of studies performed in human and animal models of PD, it has been shown that long-term increased physical activity improves behavioural patterns of movement, and enhances angiogenesis, neurogenesis and synaptogenesis in the brain. It also affects the activation of signaling pathways of neurotrophic factors. The forms of physical activity which are currently known to provide relief for the symptoms of PD are - breathing exercises, gait and balance exercises, strengthening exercises, stretching, relaxation, Tai Chi and dancing.
Journal
Year
Volume
65
Issue
3
Pages
351-360
Physical description
Dates
published
2016
Contributors
  • Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Zakład Neurofizjologii, Pracownia Badań Przedklinicznych Chorób Neurodegeneracyjnych, Pasteura 3, 02-093 Warszawa, Polska
  • Nencki Institute if Experimental Biology PAS, Department of Neurophysiology, Laboratory of Preclinical Studies in Neurodegenerative Diseases, Pasteura 3, 02-093 Warszawa, Poland
  • Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Zakład Neurofizjologii, Pracownia Badań Przedklinicznych Chorób Neurodegeneracyjnych, Pasteura 3, 02-093 Warszawa, Polska
  • Nencki Institute if Experimental Biology PAS, Department of Neurophysiology, Laboratory of Preclinical Studies in Neurodegenerative Diseases, Pasteura 3, 02-093 Warszawa, Poland
  • Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Zakład Neurofizjologii, Pracownia Badań Przedklinicznych Chorób Neurodegeneracyjnych, Pasteura 3, 02-093 Warszawa, Polska
  • Nencki Institute if Experimental Biology PAS, Department of Neurophysiology, Laboratory of Preclinical Studies in Neurodegenerative Diseases, Pasteura 3, 02-093 Warszawa, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-ksv65p351kz
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