Owady - alternatywne organizmy modelowe do badań chorób człowieka

• Authors: Karolina Walkowiak , Joanna Pacholska-Bogalska , Monika Szymczak , Grzegorz Rosiński
• Languages of publication: PL EN

Abstracts

PL

W ostatniej dekadzie nastąpił gwałtowny wzrost zainteresowania wykorzystaniem bezkręgowców, w tym owadów, jako organizmów modelowych w badaniach chorób człowieka. Opublikowano liczne prace, w których wykazano możliwość wykorzystania owadzich modeli w badaniach chorób neurodegeneracyjnych, cukrzycy, otyłości, czy chorób serca. Szybki rozwój technik biologii molekularnej, biotestów fizjologicznych i farmakologicznych, a także poznanie genomów muszki Drosophila melanogaster, chrząszcza Tribolium castaneum, jedwabnika Bombyx mori i pszczoły Apis mellifera dodatkowo stanowią silne wsparcie metodologiczne tego kierunku badań. Poznano szereg genów owadów, będących ortologami genów ludzkich, odpowiedzialnych za rozwój różnych chorób, zidentyfikowano wiele białek kodowanych przez te geny, scharakteryzowano ich fenotypy morfologiczne i fizjologiczne, a także opisano działanie u owadów niektórych leków stosowanych w chorobach neurodegeneracyjnych i kardiologicznych człowieka.

EN

Over the last decade the interest of using invertebrates, including insects, as model organisms in studies of human diseases has rapidly increased. Until now, hundreds of papers which demonstrate the possibility of using insect models in studies on human neurodegenerative diseases, diabetes, obesity or heart diseases were published. The rapid development of molecular biology techniques, physiological and pharmacological bioassays, as well as genome sequencing of fruit fly Drosophila melanogaster, red flour beetle Tribolium castaneum, silkworm Bombyx mori and honey bee Apis mellifera also provides a strong methodological support for this research approach. As a result of these studies a number of insect genes, orthologs of human genes known to be responsible for the development of various diseases, and many proteins encoded by these genes were identified. Also morphological and physiological phenotypes of different genes and the action of some drugs applied in neurodegenerative and cardiac diseases in humans have been characterized in insects.

• Journal: Kosmos
• Year: 2015
• Volume: 64
• Issue: 1
• Pages: 11-20

Dates

published

2015

Contributors

author

Karolina Walkowiak

• Zakład Fizjologii i Biologii Rozwoju Zwierząt, Instytut Biologii Eksperymentalnej, Wydział Biologii, Uniwersytet im. Adama Mickiewicza w Poznaniu, Umultowska 89, 61-614 Poznań, Polska

author

Joanna Pacholska-Bogalska

• Zakład Fizjologii i Biologii Rozwoju Zwierząt, Instytut Biologii Eksperymentalnej, Wydział Biologii, Uniwersytet im. Adama Mickiewicza w Poznaniu, Umultowska 89, 61-614 Poznań, Polska

author

Monika Szymczak

• Zakład Fizjologii i Biologii Rozwoju Zwierząt, Instytut Biologii Eksperymentalnej, Wydział Biologii, Uniwersytet im. Adama Mickiewicza w Poznaniu, Umultowska 89, 61-614 Poznań, Polska

author

Grzegorz Rosiński

• Zakład Fizjologii i Biologii Rozwoju Zwierząt, Instytut Biologii Eksperymentalnej, Wydział Biologii, Uniwersytet im. Adama Mickiewicza w Poznaniu, Umultowska 89, 61-614 Poznań, Polska

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