Rola adiponektyny w rozrodzie samic

• Authors: Eliza Drwal , Agnieszka Rak-Mardyła

Title variants

EN

Role of adiponectin in female reproduction

• Languages of publication: PL EN

Abstracts

PL

Tkanka tłuszczowa, poza swoją podstawową funkcją jaką jest magazynowanie energii, wykazuje działanie endokrynne. Jest miejscem produkcji bioaktywnych związków nazywanych adipokinami. Jednym z nich jest adiponektyna. Hormon ten jest białkiem o masie 30 kDa składającym się z 4 domen. APM1 - gen adiponektyny jest zlokalizowany na długim ramieniu chromosomu 3. Adiponektyna jest obecna we krwi w postaci multimerycznych frakcji. Ekspresja genu i sekrecja adiponektyny zachodzi w wielu tkankach organizmu m.in. w mięśniach, wątrobie, sercu, mózgu czy tkankach rozrodczych. Adiponektyna działa przez dwa receptory - AdipoR1 i AdipoR2, które różnią się lokalizacją narządową i sposobem działania. Adiponektyna odgrywa ważną rolę w regulowaniu metabolizmu glukozy i kwasów tłuszczowych oraz wpływa na system naczyniowo-sercowy. Ostatnie badania wskazują, że adiponektyna jest ważnym czynnikiem regulującym rozród. Obecność adiponektyny i jej receptorów wykazano w tkankach rozrodczych, takich jak jajnik. Jest zaangażowana w procesy steroidogenezy i proliferacji pęcherzyków jajnikowych. Adiponektyna oddziałuje również na centralną oś podwzgórze-przysadka-jajnik.

EN

Adipose tissue except its primary function - energy storage - exhibits endocrine activity. It is the place of production of bioactive compounds named adipokines. One of these is adiponectin. This hormone is a protein with a mass of 30 kDa composed of four domains. APM1 - gene of adiponectin is located in the long arm of third chromosome. Adiponectin is present in blood in the form of three multimeric fractions. Gene expression and secretion of adiponectin occurs in many tissues in organism, including muscle, liver, heart, brain and reproductive tissues. Adiponectin acts via two receptors - AdipoR1 and AdipoR2, which have different organ location and mode of action. Adiponectin plays an important role in regulating metabolism of glucose and fatty acids and affects the cardiovascular function. Recent studies show that adiponectin is an important factor in female reproduction. Presence of adiponectin and its receptors was demonstrated in reproductive tissues, such as ovary. The hormone is involved in ovarian follicles steroidogenesis and proliferation, as well as influences the activity of reproductive endocrine axis: hypothalamus-pituarity-ovary.

• Journal: Kosmos
• Year: 2014
• Volume: 63
• Issue: 3
• Pages: 415-428

Dates

published

2014

Contributors

author

Eliza Drwal

• Uniwersytet Jagielloński w Krakowie, Instytut Zoologii, Zakład Fizjologii i Toksykologii Rozrodu, Gronostajowa 9, 30-387 Kraków, Polska

author

Agnieszka Rak-Mardyła

• Uniwersytet Jagielloński w Krakowie, Instytut Zoologii, Zakład Fizjologii i Toksykologii Rozrodu, Gronostajowa 9, 30-387 Kraków, Polska

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