PL EN


Preferences help
enabled [disable] Abstract
Number of results
Journal
2014 | 63 | 3 | 415-428
Article title

Rola adiponektyny w rozrodzie samic

Content
Title variants
EN
Role of adiponectin in female reproduction
Languages of publication
PL EN
Abstracts
PL
Tkanka tłuszczowa, poza swoją podstawową funkcją jaką jest magazynowanie energii, wykazuje działanie endokrynne. Jest miejscem produkcji bioaktywnych związków nazywanych adipokinami. Jednym z nich jest adiponektyna. Hormon ten jest białkiem o masie 30 kDa składającym się z 4 domen. APM1 - gen adiponektyny jest zlokalizowany na długim ramieniu chromosomu 3. Adiponektyna jest obecna we krwi w postaci multimerycznych frakcji. Ekspresja genu i sekrecja adiponektyny zachodzi w wielu tkankach organizmu m.in. w mięśniach, wątrobie, sercu, mózgu czy tkankach rozrodczych. Adiponektyna działa przez dwa receptory - AdipoR1 i AdipoR2, które różnią się lokalizacją narządową i sposobem działania. Adiponektyna odgrywa ważną rolę w regulowaniu metabolizmu glukozy i kwasów tłuszczowych oraz wpływa na system naczyniowo-sercowy. Ostatnie badania wskazują, że adiponektyna jest ważnym czynnikiem regulującym rozród. Obecność adiponektyny i jej receptorów wykazano w tkankach rozrodczych, takich jak jajnik. Jest zaangażowana w procesy steroidogenezy i proliferacji pęcherzyków jajnikowych. Adiponektyna oddziałuje również na centralną oś podwzgórze-przysadka-jajnik.
EN
Adipose tissue except its primary function - energy storage - exhibits endocrine activity. It is the place of production of bioactive compounds named adipokines. One of these is adiponectin. This hormone is a protein with a mass of 30 kDa composed of four domains. APM1 - gene of adiponectin is located in the long arm of third chromosome. Adiponectin is present in blood in the form of three multimeric fractions. Gene expression and secretion of adiponectin occurs in many tissues in organism, including muscle, liver, heart, brain and reproductive tissues. Adiponectin acts via two receptors - AdipoR1 and AdipoR2, which have different organ location and mode of action. Adiponectin plays an important role in regulating metabolism of glucose and fatty acids and affects the cardiovascular function. Recent studies show that adiponectin is an important factor in female reproduction. Presence of adiponectin and its receptors was demonstrated in reproductive tissues, such as ovary. The hormone is involved in ovarian follicles steroidogenesis and proliferation, as well as influences the activity of reproductive endocrine axis: hypothalamus-pituarity-ovary.
Keywords
Journal
Year
Volume
63
Issue
3
Pages
415-428
Physical description
Dates
published
2014
References
  • Archanco M., Gomez-Ambrosi J., Tena-Sempere M., Fruhbeck G., Burrell M. A, 2007. Expression of leptin and adiponectin in the rat oviduct. J. Histochem. Cytochem. 55, 1027-1037.
  • Arita Y., Kihara S., Ouchi N., Takahashi M., Maeda K., Miyagawa J. i wsp., 1999. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Comm. 257, 79-83.
  • Behre C. J., Gummesson A., Jernas M. i współaut., 2007. Dissociation between adipose tissue expression and serum levels of adiponectin during and after diet-induced weight loss in obese subjects with and without the metabolic syndrome. Metabolism 56, 1022-1028.
  • Berner H. S., Lyngstadaas S. P., Spahr A., Monjo M., Thommesen L., Drevon C A. i wsp., 2004. Adiponectin and its receptors are expressed in bone-forming cells. Biochem. Biophys. Res. Comm. 35, 842-849.
  • Briana D. D., Malamitsi-Puchner A., 2009. Intrauterine growth restriction and adult disease: the role of adipocytokines. Eur. J. Endocrinol. 160, 337-347.
  • Brynhildsen J., Sydsjö G, Blomberg M, Claesson Im, Theodorsson E, Nyström F, Sydsjö A., Josefsson A., 2013. Leptin and adiponectin in cord blood from children of normal weight, overweight and obese mothers. Acta Paediatr. 6, 620-624.
  • Caminos J. E., Nogueiras R., Gaytan F., Pineda R., Gonzalez C. R., Barreiro M. L., Et A. L., Novel E., Caminos J. E., Nogueiras R., Gallego R., Bravo S., Tovar S., García-Caballero T. i współaut., 2005. Expression and regulation of adiponectin and receptor in human and rat placenta. J. Clin. Endocrinol. Metab. 90, 4276-4286.
  • Campos D. B., Palin M. F., Bordignon V., Murphy B. D., 2008. The beneficial adipokines in reproduction and fertility. Int J Obes. 32, 223-231.
  • Carmina E, 2004. Diagnosis of polycystic ovary syndrome: from NIH criteria to ESHRE-ASRM guidelines. Minerva Ginecol. 56, 1-6.
  • Cikos S, 2012. Adiponectin and its receptors in preimplantation embryo development. Vitam. Horm. 90, 211-238.
  • Chabrolle C., Tosca L., Crochet S., Tesseraud S., Dupont J., 2007a. Expression of adiponectin and its receptors (Adipo R1 and AdipoR2) in chicken ovary: potential role in ovarian steroidogenesis. Domest. Anim. Endocrinol. 33, 480-487.
  • Chabrolle C., Tosca L., Dupont J., 2007a. Regulation of adoponectin and its receptors in rat ovary by human chorionic gonadotrophin treatment and potential involvement of adiponectin in granulosa cell steroidogenesis. Reproduction 133, 719-731.
  • Chabrolle C., Tosca L., Rame C., Lecomte P., Royere D., Dupont J., 2009. Adiponectin increase insulin-like growth factor I-induced progesterone and estradiol secretion in human granulose cells. Fertil. Steril. 92, 1988-1996.
  • Clarke K. J., Zhong Q., Schwartz D. D., Coleman E. S., Kemppainen R. J., Judd R. L., 2003. Regulation of adiponectin secretion by endothelin-1. Biochem. Biophys. Res. Comm. 312, 945-949.
  • Delaigle A. M., Jonas J. C., Bauche I. B., Cornu O., Brichard S. M., 2004. Induction of adiponectin in skeletal muscle by inflammatory cytokines: in vivo and in vitro studies. Endocrinology 145, 5589-5597.
  • Eleuterio N. M., Palei A. C., Rangel Machado J. S., Tanus-Santos J. E., Cavalli R. C., Sandrim V. C., 2013. Relationship between adiponectin and nitrite in healthy and preeclampsia pregnancies. Clin. Chim. Acta 423, 112-115.
  • Fasshauer M., Klein J., Neumann S., Eszlinger M., Paschke R., 2001. Adiponectin gene expression is inhibited by beta-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes. FEBS Lett. 507, 142-146.
  • Fasshauer M., Kralisch S., Klier M. i współaut., 2003. Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-?-L1 adipocytes. Biochem. Biophys. Res. Comm. 301, 1045-1050.
  • Fruebis J., Tsao T. S., Javorschi S. i współaut., 2001. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc. Natl. Acad. Sci. USA 98, 2005-2010.
  • Fu Y., Luo N., Klein R. L., Garvey W. T., 2005. Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation. J. Lipid Res. 46, 1369-1379.
  • Furuhashi M., Ura N., Higashiura K. i współaut., 2003. Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertension. Hypertension 42, 76-81.
  • Goldstein B. J., Scalia R., 2004. Adiponectin: a novel adipokine linking adipocytes and vascular function. J. Clin. Endocrinol. Metab. 89, 2563-2568.
  • Hoyda T. D., Fry M., Ahima R. S., Ferguson A. V., 2007. Adiponectin selectively inhibits oxytocin neurons of the paraventricular nucleus of the hypothalamus. J. Physiol. 585, 805-816.
  • Hu E., Liang P., Spiegelman B. M., 1996. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem. 271, 10697-10703.
  • Huypens P. R., 2007. Leptin and adiponectin regulate compensatory beta cell growth in accordance to overweight. Med. Hypothes. 68, 1134-1137.
  • Kadowaki K., Waguri M., Nakanishi I., Miyashita Y., Nakayama M., Suehara N. i współaut., 2006. Adiponectin concentration in umbilical cord serum is positively associated with the weight ratio of fetus to placenta. J. Clin. Endocrinol. Metab. 91, 5090-5094.
  • Kadowaki T., Yamauchi T., 2005. Adiponectin and adiponectin receptors. Endocrynology 26, 439-451.
  • Kaser S., Moschen A., Cayon A. i współaut., 2005. Adiponectin and its receptors in non-alcoholic steatohepatitis. Gut 54, 117-121.
  • Katsikis I., Mouslech T., Kourtis A., Panidis D., Georgopoulos N. A., 2009. Oligo-ovulation or anovulation and hyperandrogenemia contribute to the decreased serum adiponectin levels in normal-weight women with PCOS with obesity and insulin resistance. Fertil Steril. 91, e3.
  • Kelesidis I., Kelesidis T., Mantzoros C. S., 2006. Adiponectin and cancer: a systematic review. Brit. J. Cancer 94, 1221-1225.
  • Kershaw E. E., Flier J. S., 2004 Adipose tissue as an endocrine organ. J. Clin. Endocrinol. Metab. 89, 2548-2456.
  • Kharroubi H., Rasschaert J., Eizirik D.L., Cnop M., 2003. Expression of adiponectin receptors in pancreatic cells. Biochem. Biophys. Res. Comm. 312, 1118-1122.
  • Kiezun M., Maleszka A., Smolinska N., Nitkiewicz A., Kaminski T., 2013. Expression of adiponectin receptors 1 (AdipoR1) and 2 (AdipoR2) in the porcine pituitary during the oestrous cycle. Reprod. Biol. Endocrinol. 11, 18.
  • Kubota N., Yano W., Kubota T., Yamauchi T., Itoh S., Kumagai H., Kozono H., Takamoto I., Okamoto S., Shiuchi T., Suzuki R., Satoh H. i współaut., 2007. Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab. 6, 55-68.
  • Michalakis M. D., Segars J. H., 2010. The role of adiponectin in reproduction:from polycystic ovary syndrome to assisted reproduction; Fertil Steril. 94, 1949-1957.
  • Lacroix M., Battista M. C., Doyon M., Ménard J., Ardilouze J. L., Perron P., Hivert M. F., 2013. Lower adiponectin levels at first trimester of pregnancy are associated with increased insulin resistance and higher risk of developing gestational diabetes mellitus. Diabet. Care 36, 1577-1583.
  • Lagaly D. V., Aad P. Y., Grado-Ahuir J. A., Hulsey L. B., Spiicer L. J., 2005. Role of adiponectin in regulating ovarian theca and granulosa cell function. Mol. Cell Endocrinol. 284, 38-45.
  • Ledoux S., Campos D. B., Lopes F. L., Dobias-Goff M., Palin M. F., Murphy B. D., 2006. Adiponectin Induces Periovulatory Changes in Ovarian Follicular Cells. Endocrinology 147, 5178-5186.
  • Lord E., Ledoux S., Murphy B. D., Beaudry D., Palin M. F., 2005. Expression of adiponectin and its receptors in swine. J. Anim. Sci. 83, 565-578.
  • Lu M., Tang Q., Olefsky J. M., Mellon P. L., Webster N. J., 2008 Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes. Mol. Endocrinol. 22, 760-771.
  • Maeda K., Okubo K., Shimomura I., Funahashi T., Matsuzawa Y., Matsubara K., 1996. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (adipose most abundant gene transcript 1). Biochem. Biophys. Res. Commun. 221, 286-289.
  • Maeda N., Takahashi M., Funahashi T. i współaut., 2001. PPARg ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 50, 2094-2099.
  • Maillard V., Uzbekova S., Guignot F., Perreau C., Rame C., Coyral-Castel S., Dupont J., 2010. Effect of adiponectin on bovine granulosa cell steroidogenesis, oocyte maturation and embryo development. Reprod Biol Endocrinol. 8, 23.
  • Matuszek B., Burska A., Leszczyńska-Gorzelak B., Donica H., Nowakowski A., 2013. Comparative analysis of adiponectin isoform distribution in pregnant women with gestational diabetes mellitus and after delivery. Acta Obstet Gynecol Scand. 92, 851-859.
  • Mazaki-Tovi S., Kanety H., Pariente C., Hemi R., Efraty Y., Schiff E. i współaut., 2007a. Determining the source of fetal adiponectin. J. Reprod. Med. 52, 774-778.
  • Mazaki-Tovi S., Kanety H., Pariente C., Hemi R., Wiser A., Schiff E., Sivan E., 2007b. Maternal serum adiponectin levels during human pregnancy. J. Perinatol. 27, 77-81.
  • Miller M., Cho J. Y., Pham A., Ramsdell J., Broide D. H., 2009. Adiponectin and functional adiponectin receptor 1 are expressed by airway epithelial cells in chronic obstructive pulmonary disease. J. Immunol. 182, 684-691.
  • Mitchell M., Armstrong D. T., Robker R. L., Norman R. J., 2005. Adipokines: implications for female fertility and obesity. Reproduction 130, 583-597.
  • Nakano Y., Tobe T., Choi-Miura N. H., Mazda T., Tomita M., 1996. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma. J. Biochem. 120, 803-812.
  • Nishizawa H., Shimomura I., Kishida K., Maeda N., Kuriyama H., Nagaretani H., Matsuda M., Kondo H., Furuyama N., Kihara S., Nakamura T., Tochino Y., Funahashi T., Matsuzawa Y., 2002. Androgens decrease plasma adiponectin, an insulinsensitizing adipocyte-derived protein. Diabetes 51, 2734-2741.
  • Ouchi N., Shibata R., Walsh K., 2006. Cardioprotection by adiponectin. Trends Cardiovasc. Med. 16, 141-146.
  • Ouchi N., Parker J. L., Lugus J. J., Walsh K., 2011. Adipokines in inflammation and metabolic disease. Nat. Rev. Immunol. 11, 85-97.
  • Palin M. F., Bordignon V. V., Murphy B. D., 2012. Adiponectin and the control of female reproductive functions. Vitam. Horm. 90, 239-287.
  • Panidis D., Kourtis A., Farmakiotis D., Mouslech T., Rousso D., Koliakos G., 2003. Serum adiponectin levels in women with polycystic ovary syndrome. Hum. Reprod. 18, 1790-1796.
  • Park S. K., Oh S. Y., Lee M. Y., Yoon S., Kim K. S., Kim J. W., 2004. CCAAT/enhancer binding protein and nuclear factor-Y regulate adiponectin gene expression in adipose tissue. Diabetes 53, 2757-2766.
  • Pineiro R., Iglesias M. J., Gallego R. i współaut., 2005. Adiponectin is synthesized and secreted by human and murine cardiomyocytes. FEBS Lett. 579, 5163-5169.
  • Psilopanagioti A., Papadaki H., Kranioti E. F., Alexandrides T. K., Varakis J. N., 2009. Expression of adiponectin and adiponectin receptors in human pituitary gland and brain. Neuroendocrinology 89, 38-47.
  • Qi Y., Takahashi N., Hileman S. M. i współaut., 2004. Adiponectin acts in the brain to decrease body weight. Nat. Med. 10, 524-529.
  • Qiao L., Maclean P. S., Schaack J. i współaut., 2005. C/EBPa regulates human adiponectin gene transcription through an intronic enhancer. Diabetes 54, 1744-1754.
  • Rodriguez-Pacheco F., Martinez-Fuentes A. J., Tovar S., Pinilla L., Tena-Sempere M., Dieguez C., 2007. Regulation of pituitary cell function by adiponectin. Endocrinology 148, 401-410.
  • Scherer P. E., Williams S., Fogliano M., Baldini G., Lodish H. F., 1995. A novel serum protein similar to C1q produced exclusively in adipocytes. J. Biol. Chem. 270, 26746-2679.
  • Simón-Muela I., Näf S., Ballesteros M., Vendrell J., Ceperuelo-Mallafre V., De La Flor M,. Megia A., 2013. Gender determines the actions of adiponectin multimers on fetal growth and adiposity. Am. J. Obstet. Gynecol. 208, 481.e1-481.e7.
  • Singh A., Krishna A., 2012. Effects of adiponectin on ovarian folliculogenesis and steroidogenesis in the vespertilionid bat, Scotophilus heathi. Gen. Comp. Endocrinol. 178, 502-510.
  • Sparks L. M., Pasarica M., Sereda O. i współaut., 2009. Effect of adipose tissue on the sexual dimorphism in metabolic flexibility. Metabolism 58, 1564-1571.
  • Tabandeh M. R., Hosseini A., Saeb M., Kafi M., Saeb S., 2010. Changes in the gene expression of adiponectin and adiponectin receptors (AdipoR1 and AdipoR2) in ovarian follicular cells of dairy cow at different stages of development. Theriogenology 73, 659-669.
  • Takahashi M., Arita T., Yamagata K., Matsukawa Y., Okutomi K., Horie M., Shimomura I., Hotta K., Kuriyama H., Kihara S., Nakamura T., Yamashita S., Funahashi T., Matsuzawa Y., 2000. Genomic structure and mutations in adipose-specifi c gene, adiponectin. Int. J. Obes. Relat. Metab. Disord. 24, 861-868.
  • Tomas E., Tsao T.-S., Saha A. K., Murrey H. E., Zhang C. C., Itani S. I. i współaut., 2002. Enhanced muscle fat oxidation and glucose transport by Acrp30 globular domain:acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc. Natl. Acad. Sci. USA. 99, 16309-11633.
  • Toulis K. A., Goulis D. G., Farmakiotis D., Georgopoulos N. A., Katsikis I., Tarlatzis B. C., 2009. Adiponectin levels in women with polycystic ovary syndrome: a systematic review and a meta-analysis. Hum. Reprod. Update. 15, 297-307.
  • Trayhurn P., Beattie J. H., 2001, Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc. Nutr. Soc. 60, 329-339.
  • Waki H., Yamauchi T., Kamon J. i współaut., 2003. Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J. Biol. Chem. 278, 40352-40363.
  • Wickham E. P. 3rd, Tao T., Nestler J. E., Mcgee E. A., 2013. Activation of the LH receptor up regulates the type 2 adiponectin receptor in human granulosa cells. J. Assist. Reprod. Genet. 30, 963-968.
  • Woźniak S. E., Gee L. L., Wachtel M. S., Frezza E. E, 2009. Adipose tissue: the new endocrine organ? A review article. Dig. Dis. Sci. 54, 1847-1856.
  • Yamauchi T., Kamon J., Waki H., Terauchi Y., Kubota N., Hara K., 2001. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 7, 941-946.
  • Yamauchi T., Kamon J., Minokoshi Y., Ito Y., Waki H., Uchida S. i współaut., 2002. Adiponectin stimulates glucose utilisation and fatty acid oxidation by activating AMP-activated protein kinase. Nat. Med. 8, 1288-1295.
  • Yamauchi T., Kamon J., Ito Y. i współaut., 2003. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423, 762-769.
  • Ye Y., Pu D., Liu J., Li F., Cui Y., Wu J., 2013. Adiponectin gene polymorphisms may not be associated with idiopathic premature ovarian failure. Gene 518, 262-266.
  • Zhang Y., Matheny M., Zolotukhin S., Tumer N., Scarpace P. J., 2002. Regulation of adiponectin and leptin gene expression in white and brown adipose tissues: influence of b3-adrenergic agonists, retinoic acid, leptin and fasting. Biochim. Biophys. Acta 1584, 115-122.
Document Type
Publication order reference
YADDA identifier
bwmeta1.element.bwnjournal-article-ksv63p415kz
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.