Wpływ otyłości na metabolizm żelaza

• Authors: Justyna Kwapisz , Artur Słomka , Justyna Blekicka , Ewa Żekanowska

Title variants

EN

The impact of obesity on iron metabolism

• Languages of publication: PL EN

Abstracts

PL

Otyłość odgrywa kluczową rolę w etiologii takich chorób jak zespół metaboliczny, cukrzyca typu 2, nadciśnienie tętnicze, udar niedokrwienny mózgu, zawał mięśnia sercowego oraz nowotwory złośliwe. W ostatnich latach obserwuje się niepokojący wzrost częstości występowania otyłości u dzieci i młodzieży. Z badań epidemiologicznych prowadzonych w Polsce wynika, że aż u 18,7% chłopców i 14,1% dziewcząt w wieku szkolnym występuje nadwaga lub otyłość. Konsekwencje zdrowotne otyłości u dzieci i młodzieży są bardzo poważne i predysponują do rozwoju chorób cywilizacyjnych. Badania eksperymentalne poparte obserwacjami klinicznymi wskazują na istotny związek otyłości z zaburzeniami metabolizmu żelaza. Bardzo często u osób otyłych stwierdza się niedobór żelaza dostępnego dla erytropoezy i syntezy hemoglobiny. Obecnie uznaje się, że kluczowymi czynnikami zaangażowanymi w patomechanizm zaburzeń homeostazy żelaza u osób otyłych jest przewlekły proces zapalny i zdolność tkanki tłuszczowej do produkcji hepcydyny.

EN

Obesity is a preeminent public health problem which is associated with increased risk of heart and hypertensive diseases, type 2 diabetes, ischemic stroke and different types of cancer. Additionally, the number of overweight and obese children has grown rapidly in recent years. In Poland, the prevalence of overweight and obesity reaches presently 18.7% and 14.1% among school-aged boys and girls, respectively. Obese children are more likely to suffer from diseases related to contemporary civilization both during childhood and in later adult life. Experimental and clinical studies suggest a potential link between obesity and altered iron metabolism. Iron deficiency is significantly more prevalent among obese individuals. Mechanisms of obesity-associated disturbances in iron metabolism are currently undefined. Obesity is regarded as a pro-inflammatory condition characterised by the presence of low-grade systemic inflammation. The obesity-related inflammation and obesity-related hepcidin production seem to be the most probable reasons of development of hypoferremia in obesity. Understanding the role of obesity in the pathogenesis of iron disorders may be an important step in the development of more effective treatment therapies.

• Journal: Kosmos
• Year: 2014
• Volume: 63
• Issue: 3
• Pages: 381-386

Dates

published

2014

Contributors

author

Justyna Kwapisz

• Wydział Farmaceutyczny, Katedra Patofizjologii, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu, M. Skłodowskiej-Curie 9, 85-094 Bydgoszcz, Polska

author

Artur Słomka

• Wydział Farmaceutyczny, Katedra Patofizjologii, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu, M. Skłodowskiej-Curie 9, 85-094 Bydgoszcz, Polska

author

Justyna Blekicka

• Wydział Farmaceutyczny, Katedra Patofizjologii, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu, M. Skłodowskiej-Curie 9, 85-094 Bydgoszcz, Polska

author

Ewa Żekanowska

• Wydział Farmaceutyczny, Katedra Patofizjologii, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu, M. Skłodowskiej-Curie 9, 85-094 Bydgoszcz, Polska

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