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2012 | 61 | 1 | 83-92
Article title

Alkohol a opioidy

Title variants
Alcohol and opioids
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Obecnie jest opisanych wiele rodzajów receptorów opioidowych oraz mechanizmów ich działania. Etanol, jako środek narkotyczny i powodujący uzależnienia, wchodzi z nimi w specyficzne interakcje, między innymi uaktywniając mechanizmy pobudzania. Niektóre opioidy wywierają wpływ na spożywanie alkoholu, a np. morfina może hamować jego przyjmowanie. Alkohol osłabia też odczuwanie bólu i na tym tle może wywoływać uzależnienie. Dane licznego piśmiennictwa na ten temat nie są jednak jednoznaczne, a tematyka współzależności między alkoholem a opioidami wymaga dalszych obserwacji.
Many kinds of opioids and opioid receptors in the central nerve system have been discovered and their physiological activities described. Ethanol, as a narcotic drug causing the addiction, interacts specifically with opioid receptor systems activating inter alia mechanisms of nerve excitation. Some opioids exert influence on the intake of alcohol; morphine for example can reduce desire for its drinking. Alcohol reduces also the feeling of pain; so that it's on purpose consumption may lead to the addiction. Numerous literature data on this subject are susceptible to different interpretations; therefore correlation between alcohol and opioid drugs interaction requires further studies.
Physical description
  • Miejski Ośrodek Profilaktyki i Terapii Uzależnień, Niciarniana 41, 92-320 Łódź, Polska
  • Praktyka Lekarska, Mehoffera 160 J/1, 03-081 Warszawa, Polska
  • Balenko S., 1979. Alcohol abuse by heroin addicts: review of research findings and issues. Int. J. Addict. 14, 965-975.
  • Barr C. S., Schwandt M. L., Newman T. K., Higley D. J., 2004. The use of adolescent nonhuman primates to model human alcohol intake: neurobiological, genetic, and psychiological variables. Ann. N. Y. Acad. Sci. 1021, 221-233.
  • Beaman C. M., Hunter G. A., Donn L. L., Reid L. D., 1984. Opioids, benzodiazepines and intake of ethanol. Alcohol 1, 39-42.
  • Blum K.,1983. Alcohol and central nervous peptides. Substance Alcohol Actions Misuse 4, 73-87.
  • Butler R. K., Finn D. P., 2009. Stress-induced analgesia. Progr. Neurobiol. 88, 184-202.
  • Campbell V. C, Taylor R. E., Tizabi Y., 2006. Antinociceptive effects of alcohol and nicotine: involvement of the opioid system. Brain Res. 1097, 71-77.
  • Campbell V. C., Taylor R. E., Tizabi Y., 2007. Effects of selective opioid receptor antagonists on alcohol-induced and nicotine-induced antinociception. Alcohol. Clin. Exp. Res. 31, 1435-1440.
  • Carter G. T., Sullivan, M. D., 2002. Antidepressants in pain management. Curr. Opin. Investigat. Drugs 3, 454-458.
  • Cryan J. F., Mombereau C., Vassout, A., 2005. The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. Neurosci. Biobehav. Rev. 29, 571-625.
  • Dean A. J., Saunders J. B., Jones R. T., Young R. M., Connor J. P., Lawford B. R., 2006. Does naltrexone treatment lead to depression? Findings from a randomized controlled trial in subjects with opioid dependence. J. Psychiatry Neurosci. 31, 38-45.
  • Drolet G., Dumont E. C., Gosselin I., Kinkead R., Laforest S., Trottier J. F., 2001. Role of endogenous opioid system in the regulation of the stress response. Progress Neuro-Psychopharmacol. Biol. Psychiatry 25, 729-741.
  • Dudziak M., Dziwiński T., Majewski P., 2001. Endogenne opioidy - charakterystyka i wybrane funkcje. [W:] Fizjologia zwierząt. Zagadnienia wybrane. Sotowska-Brocka J. (red.). Wyd. Uniw. Warszawskiego, Warszawa, 125-146.
  • Dumont E. C., Kinkead R., Trottier J. F., Gosselin I., Drolet G., 2000. Effect of chronic psychogenic stress exposure on enkephalin neuronal activity and expression in the rat hypothalamic paraventricular nucleus. J. Neurochemistry 75, 2200-2211.
  • Evans C. J., 2004. Secrets of the opium poppy revealed. Neuropharmacology 47, S293-S299.
  • Frederickson R. C., Geary L. E., 1982. Endogenous opioid peptides: review of physiological, pharmacological and clinical aspects. Progress Neurobiol. 19, 19-69.
  • Gianoulakis C., Woo N., Drouin J. N., Seidach N. G., Kalant G., Chretien M.,1982. Biosynthesis ofβ-endorphin by the neurointermediate lobes from rats treated with morphine or alcohol. Life Sci. 29, 1973-1982.
  • Gianoulakis C., De Waele J. P., Thavundayil J., 1996. Implication of the endogenous opioid system in excessive ethanol consumption. Alcohol 13, 19-23.
  • Goodsell D. S., 2004. The molecular perspective: morphine. Oncologist 9, 717-718.
  • Goodwin D. W., Davis D. H., Robins L. N., 1975. Drinking amid abundal illicit drugs. Arch. Gen. Psychiatry 32, 230-233.
  • Guedes R. C.A., de Azeredo F. A. M., Hicks T. P., Clarke R. J., Tashiro T., 1987. Opioid mechanisms involved in the slow potential change and neuronal refractoriness during cortical spreading depression. Exp. Brain Res. 69, 113-120.
  • Heath A. C., Todorow A. A., Nelson E. C., Madden P. A., Bucholz K. K., Martin N. G., 2002. Gene-environment interaction effects on behavioral variation and risk of complex disorders: the example of alcoholism and other psychiatric disorders. Twin Res. Official J. Internat. Soc. Twin Studies. 5, 30-37.
  • Hebb A. L., Zacharko R. M., Gauthier M., Trudel F., Laforest S., Drolet G., 2004. Brief exposure to predator odor and resultant anxiety enhances mesocorticolimbic activity and enkephalin expression in CD-1 mice. Eur. J. Neurosci. 20, 2415-2429.
  • Hermandez L. L., Watson K. L., 1997. Opioid modulation of attention related responses Delta - receptors modulate habituation and conditioned bradycardia. Psychopharmacol.131, 140-148.
  • Herz A., 1998. Opioid reward mechanism: a key role in drug abuse? Can. J. Physiol. Pharmacol. 76, 252-258.
  • Ho A. K. S., 1982. Suppression of ethanol consumption by MET-enkephalin in rats. J. Pharm. Pharmacol. 34, 118-119.
  • Holden R. J., Pakula I. S., Mooney P. A., 1997. A neuroimmunological model of schizophrenia and major depression. A review. Human Psychopharmacol. 12, 177-185.
  • Horvath G., 2000. Endomorphin-1 and endomorphin-2: pharmacology of the selective endogenous mu-opioid receptor agonists. Pharmacol. Therapeutics. 88, 437-463.
  • Horvath G., Kekesi G., 2006. Interaction of endogenous ligands mediating antinociception. Brain Res. Rev. 52, 69-92.
  • Hughes J., 1975. Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine. Brain Res. 88, 295-308.
  • Jan M. W., Slade J. H., 2007. Antidepressant agents for the treatment of chronic pain and depression. Pharmacotherapy 27, 1571-1587.
  • Jolkonnen J. T., Soinien H. S., Riekkinen P. J., 1984. Cerebrospinal fluid cholinesterase, beta - endorphin and somatostatin in Alzheimer's disease. Acta Univer. Temper. 21, 104-111.
  • Kalant H., 1987. Current trends in biomedical research on alcohol. Alcohol Alcoholism Suppl. 1, 1-12.
  • Kavaliers M., 1988. Evolutionary and comparative aspects of nociception. Brain Res. Bull.21, 923-931.
  • Klinowiecka A., Kosson P., Sacharczuk M., Gajkowska B., Lipkowski A.W., 2007. Blood brain barier permeability and analgesic of opioid peptide-biphalin given peripherally in mice bred for swim-stress induced analgesia (SSIA). 19th Polish Peptide Symposium, Pułtusk, 23-27
  • Klinowiecka A., Kosson P., Gajkowska B., Sacharczuk M., Sadowski B., Lipkowski A.W., 2009. Analgesis activity of opioid peptides in mice bred for stress induced analgesia. XX Polish Peptide Symposium, Władysławowo, 26-29.
  • Klinowiecka A., Kosson P., Leśniak A., Sacharczuk M., Sadowski B., Lipkowski A.W., 2010. Comparable antinociceptive effect of biphalin in mice selected for high and low swim stress-induced analgesia after blood-brain barrier disruption caused by hypersomal mannitol administration. VII Multidsycyplinarna Konf. Nauki o Leku, Zakopane, Acta Pol. Pharmaceutica, 31-34.
  • Kołątaj A., 1993. Pochwała stresu. Wyd. Wyższej Szkoły Pedagogicznej w Kielcach, Kielce.
  • Kostowski W., 1991. Neurofizjologiczne aspekty działania etanolu - zagadnienia wybrane. [W:] Działanie biologiczne alkoholu etylowego. Kostowski W., Wald I. (red.). PWN, Warszawa, 196-206.
  • Kozicz T., 2002. Met-enkephalin immunoreactive neurons recruited by acute stress are innervated by axon terminals immunopositive for tyrosine hydroxylase and dopamine-alpha-hydroxylase in the anterolateral division of bed nuclei of the stria terminalis in the rat. Eur. J. Neurosci. 16, 823-835.
  • Kumański K., 2009. Influence of vitamin A and restricted protein in food on lysosomal enzyme activity in the mouse liver and kidney. Wyd. SGGW w Warszawie, Warszawa.
  • Langbehn D. R., Cadoret R. J., Caspers K., Troughton E. P., Yucius R., 2003. Genetic and environemental risk factors for the onset of drug use and problems in adoptes. Drug Alcohol Dependence 69, 151-167.
  • Langwiński R., 1991. Etanol a opioidy. [W:] Działanie biologiczne alkoholu etylowego. Kostowski W., Wald I. (red.) PWN, Warszawa, 167-195.
  • Law P. Y., Loh, H. H., Wei L. N., 2004. Insights into the receptor transcription and signaling: implications in opioid tolerance and dependence. Neuropharmacology 47, S300-S311.
  • Leśniak A., Sacharczuk M., Kosson P., Rafałowska J., Gadamski R., Lipkowski A. W., 2010. Assesment of analgesic potency of biphalin in a mouse model of cancer pain. VII Multidyscypl. Konf. Nauki o Leku, Zakopane, Acta Pol. Pharm. 18-21.
  • Lin S., Boey D., Lee N., Schwarzer C., Sainsbury A., Herzog H., 2006. Distribution of prodynorphin mRNA and its interaction with the NPY system in the mouse brain. Neuropeptides 40, 115-123.
  • Lovinger D. M., Crabbe J. C., 2005. Laboratory models of alcoholism: treatment target identification and inshight into mechanism. Nature Neurosci. 8, 1471-1480.
  • Lüschen W., Buck F., Willig A., Jaros P. P., 1991. Isolation, sequence analysis, acid physiological properties of enkephalins in the nervous tissue of the shore crab Carcinus maenas L. Proc. Natl. Acad. Sci. USA, 88, 8671-8675.
  • Mansi J. A., Laforest S., Drolet G., 2000. Effect of stress exposure on the activation pattern of enkephalin-containing perikarya in the rat ventral medulla. J. Neurochem. 74, 2568-2575.
  • Mansour A., Khachaturian H., Lewis, M. E., Akil H., Watson S. J., 1987. Autoradiographic differentiation of mi, delta, and kappa opioid receptors in the rat forebrain and midbrain. J. Neurosci. 7, 2445-2464.
  • Matthews J., Akii H., Greden J., Charney D., Weinberg V., Rosenbaum A., Watson S. J., 1986. Beta-endorphin/beta lipotropin immuno-reactivity in endogenous depression. Arch. Gen. Psychiatry. 43, 374-381.
  • Minami M., Satoh M., 1995. Molecular biology of the opioid receptors: structures, functions and distributions. Neurosci. Res. 23, 121-145.
  • Mogil J. S., Pasternak, G. W., 2001. The molecular and behavioral pharmacology of the orphanin FQ/nociceptin peptide and receptor family. Pharmacol. Rev. 53, 381-415.
  • Nowak J. Z., Zawilska J. B., 2004. Receptory i mechanizmy przekazywania sygnału. PWN, Warszawa.
  • Ologati P., Liappas I., Malitas P., Piperi C., Colitis A., Tzavellas E. O., Zisaki A., Ferrari B., De Ronchi D., Kalofoutis A., Serreti A., 2007. Depression and social phobia secondary to alcohol dependence. Neuropsychobiol. 56, 111-118.
  • Orywal K., Jelski W., Schmitkowski M., 2009. Udział alkoholu etylowego w powstawaniu zaburzeń metabolizmu węglowodanów. Pol. Merk. Lek. 27, 68-71.
  • Oswald L. M., Wand G. S., 2004. Opioids and alcoholism. Physiol. Behav. 81, 339-358.
  • Panella J. J., Blass J. P., 1984. Lack of clinical benefit from naloxone in a dementia day hospital. Ann. Neurology 15, 308-316.
  • Pierzchała-Koziec K., 2005. Udział opioidów w procesach uczenia się i zapamiętywania. Edukacja Biol. Środ. 13, 5-9.
  • Preuss U. W., Schuckit M. A., Smith T. L., Danko G. R., Dasher A. C., Hesselbrock M. N., Hesselbrock V. M., Nurberger J. I. Jr., 2002. A comparison of alcohol-induced and independent depression in alcoholics with histories of suicide attempts. J Stud. Alcohol. 63, 498-502.
  • Przewłocka B., Przewłocki R., 2004. Receptory opioidowe. [W:] Receptory i mechanizmy przekazywania sygnału. Nowak J. Z., Zawilska J. B. (red.). PWN, Warszawa, 451-463.
  • Puciłowski O., 1991. Alkohol etylowy a układy hormonalne. [W:] Działanie biologiczne alkoholu etylowego. Kostowski W., Wald I. (red.). PWN, Warszawa, 109-127.
  • Reid L., Hunter G. A., 1984. Morphine and naloxone modulate intake of ethanol. Alcohol 1, 33-37.
  • Riedel W., Neeck G., 2001. Nociception, pain, and antinociception: current concepts. Zeitschr. Reumatol. 60, 404-415.
  • Sacharczuk M., Juszczak G., Śliwa A. T., Tymosiak-Zielińska A., Lisowski P., Jaszczak K., Pluta R., Lipkowski A., Sadowski B., Świergiel A. H., 2008. Differences in ethanol drinking between mice selected for high and low swim stress-induced analgesia. Alcohol 42, 487-492.
  • Sacharczuk M., Juszczak G., Świergiel A. H., Jaszczak K., Lipkowski A. W., Sadowski B., 2009. Alcohol reverses depressive and pronociceptive effects of chronic stress in mice with enhanced activity of the opioid system. Acta Neurobiol. Exp. 69, 138-146.
  • Sacharczuk M., Leśniak A., Korostyński M., Przewłocki R., Lipkowski A., Jaszczak K., Sadowski B., 2010a. A polymorphism in exon 2 of the delta -opioid receptor affects nociception in response to specific agonists in mice selectively bred for high and low analgesia. Pain 149, 506-513.
  • Sacharczuk M., Sadowski B., Jaszczak K., Lipkowski A.W., Świergiel A. H., 2010b. Opposite effects of alcohol in regulating stress-induced changes in body weight between the two mouse lines with enhanced or low opioid system activity. Physiol. Behav. 99, 627-631.
  • Scherrer J. F., Xian H., Shah K. R., Volber R., Slutske W., Eisen S. A., 2005. Effects genes, environment, and lifetime co-occuring disorders on health-related quality of life in problem and phatological gamblers. Arch. Gen. Psychiatry 62, 379-382.
  • Schmidt-Nielsen K., 2008. Fizjologia zwierząt. Adaptacja do środowiska. PWN, Warszawa.
  • Schulz R., Würster M., Duka T., Herz A., 1980. Acute and chronic ethanol treatment changes endorphin levels in brain and pituitary. Psychopharmacol. 68, 221-227.
  • Sinchak K., Eckersell C., Quezada V., Norell A., Micevych P., 2000. Preproenkephalin mRNA levels are regulated by acute stress and estrogen stimulation. Physiol. Behav. 69, 425-432.
  • Sood A. K., Armaiz-Pena G. N., Halder J., Nick A. M., Stone R. L., Hu W., Carroll A. R., Spannuth W. A., Deavers M. T., Allen J. K., Han L. Y., Kamat A. A., Shahzad M. M., McIntyer B. W., Diaz-Montero C. M., Jennings N. B., Lin Y. G., Merritt W. M., DeGeest K., Vivas-Mejia P. E., Lopez-Berestein G., Schaller M. D., Cole S. W., Lutgendorf S. K., 2010. Andrenergic modulation of focal adhesion kinase protecs human ovarian cancer cells from anoiks. J. Clin. Incest. 120, 1515-1523.
  • Sotowska-Brochocka J., 2001. Układ nagrody a działanie substancji psychoaktywnych. [W:] Fizjologia zwierząt. Zagadnienia wybrane. Sotowska-Brochocka J. (red.). Wyd. Uniw. Warszawskiego, 149-162.
  • Spangel R., 2003. Alcohol addiction research: from animal models to clinics. Best Practice Res. Clin. Gastroenterol. 17, 507-518.
  • Stefano G. B., Goumon Y., Casares F., Cadet P., Fricchione G. L., Rialas C., Peter D., Sonetti D., Guarna M., Welters I. D., Bianchi E., 2000. Endogenous morphine. Trends Neurosci. 23, 436-442.
  • Terenius L., Wahlstrom A. 1975. Search for an endogenous ligand for the opiate receptor. Acta Physiol. Scand.94, 74-81.
  • Torrens M., Fonseca F., Mateu G., Farre M., 2005. Efficacy of antidepressants in substance use disorders with and without comorbid depression. A systematic review and meta-analysis. Drug Alcohol Dependence 78, 1-22.
  • Wald I., 1991. Czynniki genetyczne związane z działaniem etanolu. [W:] Działanie biologiczne alkoholu etylowego. Kostowski W., Wald I. (red.). PWN, Warszawa, 262-279.
  • Waldhoer M., Bartlett, S. E., Whistler, J. L., 2004. Opioid receptors. Ann. Rev. Biochem. 73, 953-990.
  • Weiss F., Ciccocioppo R., Parsons L. H., Katner S., Liu X., Zoririlla E. P., Valdez G. R., Ben-Shahar O., Angeletti S., Richter R. R., 2001. Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors. Ann. N. Y. Acad. Sci. 937, 1-26.
  • Williams J. T., Christie M. J., Manzoni O., 2001. Cellular and synaptic adaptations mediating opioid dependence. Physiol. Rev. 81, 299-343.
  • Woronowicz B. T., 2009. Uzależnienia. Geneza, terapia, powrót do zdrowia. Media Rodzina, Poznań.
  • Zalewska-Kaszubska J., Ćwiek W., Dyr W., Czarnecka E., 2005. Changes in the beta-endorphin plasma levels after repeated treatment with acamprosate in rats selectively bred for high and low alcohol preference. Neurosci. Lett. 388, 45-48.
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