Alkohol a witaminy

• Authors: Ewa Ochwanowska , Bożena Witek , Krzysztof Kumański

Title variants

EN

Alcohol and vitamin

• Languages of publication: PL EN

Abstracts

PL

Przewlekłe nadużywanie alkoholu prowadzi do niedożywienia, a tym samym do niedoboru wielu składników pokarmowych głównie witamin A, B, C, D, E i K oraz mikroelementów (Zn, Ca, Se). Obniżenie funkcji biologicznych witamin, a także stres oksydacyjny indukowany alkoholem etylowym może prowadzić do poważnych następstw klinicznych, między innymi do niedokrwistości makrocytowej i megaloblastycznej, zaburzeń neurologicznych, przewlekłych chorób wątroby. Biochemicznym skutkiem niedoboru kwasu foliowego jest podwyższone stężenie homocysteiny we krwi, nazywanej cholesterolem XXI w. Nadmiar homocysteiny we krwi jest z kolei związany ze zwiększonym ryzykiem wystąpienia chorób sercowo-naczyniowych. Hiperhomocysteinemia może być jednym z markerów toksycznego działania alkoholu.

EN

Chronic alcohol abuse leads to malnutrition, and thus to the deficiency of many nutrients, mainly vitamins A, B, C, D, E and K and microelements (Zn, Ca, Se). Reduction of biological functions of vitamins and oxidative stress induced by ethanol can have serious clinical consequences, including macrocytic and megaloblastic anemia, neurological disorders, and chronic liver diseases. Deficiency of folic acid is connected with increased concentration in blood of homocysteine, named "cholesterol of XXI. century". High levels of homocysteine in blood are in turn associated with an increased risk of cardiovascular diseases. Hiperhomocysteinemia may serve as one of the markers of alcohol toxic effects.

• Journal: Kosmos
• Year: 2012
• Volume: 61
• Issue: 1
• Pages: 57-66

Dates

published

2012

Contributors

author

Ewa Ochwanowska

• Zakład Fizjologii Zwierząt, Instytut Biologii, Uniwersytet Jana Kochanowskiego w Kielcach, Świętokrzyska 15, 25-406 Kielce, Polska

author

Bożena Witek

• Zakład Fizjologii Zwierząt, Instytut Biologii, Uniwersytet Jana Kochanowskiego w Kielcach, Świętokrzyska 15, 25-406 Kielce, Polska

author

Krzysztof Kumański

• Samodzielny Publiczny Zakład Opieki Zdrowotnej, Miejski Ośrodek Profilaktyki i Terapii Uzależnień im. bł. Rafała Chylińskiego w Łodzi, Niciarniana 41, 92-320 Łódź, Polska

References

• Adachi Y. U., Watanabe K., Higuchi H., Satoh T., Vizi E. S., 2001. Oxygen inhalation enhances striatal dopamine metabolism and monoamine-oxidase enzyme inhibition prevents it: a microdialysis study. Eur. J. Clin. Pharmacol. 422, 61-68.
• Adams J., Pepping J., 2005. Vitamin K in the treatment and prevention of osteoporosis and arterial calcification. Am. J. Health Syst. Pharm. 62, 1574-1581.
• Asai H., Imaoka S., Kuroki T., Monna T., Funae Y., 1996. Microsomal ethanol oxidizing system activity by human hepatic cytochrome P450s. J. Pharmacol. Exp. Ther. 277, 1004-1009.
• Aslan K., Bozdemir H., Unsal C., Güvenc B., 2008. The effect of antiepileptic drugs on vitamin B12 metabolism. Int. J. Lab. Hematol. 30, 26-35.
• Augustyniak A., Michalak K., Skrzydlewska E., 2005. The action of oxidative stress induced by ethanol on the central nervous system (CNS). Postępy Hig. Med. Dosw. 59, 464-471.
• Bjørneboe G. A., Johnsen J., Bjørneboe A., Mørland J., Drevon C. A., 1987. Effect of heavy alcohol consumption on serum concentrations of fat-soluble vitamins and selenium. Alcohol Alcohol. 1, 533-537.
• Casagrande G., Michot F., 1989. Alcohol-induced bone marrow damage: status before and after a 4-week period of abstinence from alcohol with or without disulfiram. A randomized bone marrow study in alcohol-dependent individuals. Blut 59, 231-236.
• Chan P. H., Kinouchi H., Epstein C. J., Carlson E., Chen S. F., Imaizumi S., Yang G. Y., 1993. Role of superoxide dismutase in ischemic brain injury: reduction of edema and infarction in transgenic mice following ocal cerebral ischemia. Prog. Brain Res. 96, 97-104.
• Chung J. H., Rubin R. J., Cha Y. N., 1993. Effects of vitamin K1 and menadione on ethanol metabolism and toxicity. Drug Chem. Toxicol. 16, 383-394.
• Chung J., Veeramachaneni S., Liu C., Mernitz H., Russell R. M., Wang X. D., 2009. Vitamin E supplementation does not prevent ethanol-reduced hepatic retinoic acid levels in rats. Adv. Food Nutr. Res. 29, 664-670.
• Cravo M. L., Gloria L. M., Selhub J., Nadeau M. R., Camilo M. E., Resende M. P., Cardoso J. N., Leitão C. N., Mira F. C., 1996. Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B12, and vitamin B6 status. Am. J. Clin. Nutr. 63, 220-224.
• Cylwik B., Chrostek L., 2011. Zaburzenia metabolizmu kwasu foliowego i homocysteiny w warunkach nadużywania alkoholu. Pol. Merkur. Lekarski 30, 295-299.
• Cylwik B., Czygier M., Daniluk M., Chrostek L., Szmitkowski M., 2010. Stężenie witaminy B12 we krwi alkoholików. Pol. Merkur. Lekarski 28, 122-125.
• Dan Z., Popv Y,. Patsenker E., 2005. Hepatotoxicity of alcohol-induced polar retinol metabolites involves apoptosis via loss of mitochondrial membrane potential. FASEB J. 19, 845-847.
• Dankner R., Chetrit A., Murad H., Sela B. A., Frystyk J., Raz I., Flyvbjerg A., 2010. Serum adiponectin is associated with homocysteine in elderly men and women, and with 5,10-methylenetetrahydrofolate reductase (MTHFR) in a sex-dependent manner. Metabolism 59, 1767-1774.
• Das N. P., 1989. Effects of vitamin A and its analogs on nonenzymatic lipid peroxidation in rat brain mitochondria. J. Neurochem. 52, 585-588.
• De Feo T. M., Fargion S., Duca L., Cesana B. M., Boncinelli L., Lozza P., Capellini M. D., Fiorelli G., 2001. Non-transferrin-bound iron in alcohol abusers. Alcohol. Clin. Exp. Res. 25, 1494-1499.
• Deng X. S., Deitrich R. A., 2007. Ethanol metabolism and effects: nitric oxide and its interaction. Curr. Clin. Pharmacol. 2, 145-153.
• Devi B. G., Henderson G. I., Frosto T. A., Schenker S., 1993. Effect of ethanol on rat fetal hepatocytes: studies on cell replication, lipid peroxidation and glutathione. Hepatology 18, 648-659.
• Endo I., Inoue D., Mitsui T., Umaki Y., Akaike M., Yoshizawa T., Kato S., Matsumoto T., 2003. Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology 144, 5138-5144.
• Faut M., Rodríguez de Castro C., Bietto F. M., Castro J. A., Castro G. D., 2009. Metabolism of ethanol to acetaldehyde and increased susceptibility to oxidative stress could play a role in the ovarian tissue cell injury promoted by alcohol drinking. Toxicol. Ind. Health 25, 525-538.
• Fava M., Mischoulon D., 2009. Folate in depression: efficacy, safety, differences in formulations, and clinical issues. J. Clin. Psychiatry70, 12-17.
• Frank O., Luisada-Opper A., Sorrell M. F., Zetterman R., Baker H., 1976. Effects of a single intoxicating dose of ethanol on the vitamin profile of organelles in rat liver and brain. Am. J. Clin. Nutr. 106, 606-614.
• Giovannucci E., 2004. Alcohol, one carbon metabolism, and colorectal cancer recent insights from molecular studies. J. Nutr. 134, 2475S-2481S.
• Giovannucci E., Rimm E. B., Ascherio A. Stampfer M. J., Colditz G. A., Willett W. C., 1995. Alcohol, low-methionine-low-folate diets, and risk of colon cancer in men. J. Natl. Cancer Inst.87, 265-273.
• Giovannucci E., Stampfer M. J., Colditz G. A., Hunter D. J., Fuchs C., Rosner B. A., Speizer F. E., Willett W. C., 1998. Multivitamin use, folate, and colon cancer in women in the Nurses' Health Study. Ann. Intern. Med. 129, 517-524.
• González-Reimers E., Durán-Castellón M. C., Martín-Olivera R., López-Lirola A., Santolaria-Fernández F., De la Vega-Prieto M. J., Pérez-Ramírez A., García-Valdecasas Campelo E., 2005. Effect of zinc supplementation on ethanol-mediated bone alterations. Food Chem. Toxicol. 43, 1497-1505.
• González-Reimers E., Durán-Castellón M. C., López-Lirola A., Santolaria-Fernández F., Abreu-González P., Alvisa-Negrín J., Sánchez-Pérez M. J., 2010. Alcoholic myopathy: vitamin D deficiency is related to muscle fibre atrophy in a murine model. Alcohol Alcohol. 45, 223-230.
• Grummer M. A., Zachman R. D., 1990. The effect of maternal ethanol ingestion on fetal vitamin A in the rat. Pediatr. Res. 28, 186-189.
• Grummer M. A., Langhough R. E., Zachman R. D., 1993. Maternal ethanol ingestion effects on fetal rat brain vitamin A as a model for fetal alcohol syndrome. Alcohol. Clin. Exp. Res. 17, 592-597.
• Gutteridge J. M., Quinlan G. J., 1993. Antioxidant protection against organic and inorganic oxygen radicals by normal human plasma: the important primary role for iron-binding and iron-oxidising proteins. Biochim. Biophys. Acta1156, 144-150.
• Halliwell B. Gutteridge J. M., 1995. The definition and measurement of antioxidants in biological systems. Free Radic. Biol. Med.18, 125-126.
• Halsted C. H., Villanueva J., Chandler C. J., Stabler S. P., Allen R. H., Muskhelishvili L., James S. J., Poirier L., 1996. Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation. Hepatology 23, 497-505.
• Halsted C. H., Villanueva J. A., Devlin A. M., 2002. Interactions of ethanol and folate deficiency in development of alcoholic liver disease in the mircopig. Trans. Am. Clin. Climatol. Assoc. 113, 151-163.
• Hamilton B., 2010. Vitamin D and human skeletal muscle. Scand. J. Med. Sci. Sports 20, 182-190.
• Heaf J. G., Molsted S., Harrison A. P., Eiken P., Prescott L., Eidemak I., 2010. Vitamin D, surface electromyography and physical function in uraemic patients. Nephron. Clin. Pract. 115, 244-250.
• Hoek J. b., Pastorino J. G., 2002. Ethanol, oxidative stress and cytokine - induced liver cell injury. Adv. Alcohol Subst. Abuse27, 63-68.
• Homann N., Tillonen J., Salaspuro M., 2001. Heavy alcohol intake leads to local colonic folate deficiency in rats; Evidence of microbial acetaldehyde productionfrom ethanol as the pathogenic substance. Int. J. Cancer 86, 169-173.
• Jacques P. F., Bostom A. G., Wilson P. W., Rich S., Rosenberg I. H., Selhub J., 2001. Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am. J. Clin. Nutr. 73, 613-621.
• Jędrychowski W., 1994.Ethanol as a risk factor in the pathogenesis of precancerous states and changes in the gastric mucous membrane. Przegląd Epidemiologiczny 48, 511-518.
• Ji C., Kaplowitz N., 2004. Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury. World J. Gastroenterol. 10, 1699-1708.
• Jordao A. A., Chiarello P. G., Arantes M. R., Mirelles M. S., Vannucchi H., 2004. Effect of an acute dose of ethanol on lipid peroxidation in rats: action of vitamin E. Food Chem. Toxicol. 42, 459-464.
• Kaferle J., Strzoda C. E., 2009. Evaluation of macrocytosis. Am. Fam. Physician. 79, 203-208.
• Kalus U., Pruss A., Wodarra J., Kiesewetter H., Salama A., Radtke H., 2008. Influence of blood donation on levels of water-soluble vitamins. 18, 360-365.
• Karakuła H., Opolska A., Kowal A., Domański M., Płotka A., Perzyński J., 2009. Does diet affect our mood? The significance of folic acid and homocysteine. Pol. Merkur. Lekarski 26, 136-141.
• Kato S., Kawase T., Alderman J., Inatomi N., Lieber C. S., 1990. Role of xanthine oxidase In ethanol-induced lipid peroxidation in rats. Gastroenterology 98, 203-210.
• Kawakami Y., Ohuchi S., Morita T., Sugiyama K., 2009. Hypohomocysteinemic effect of cysteine is associated with increased plasma cysteine concentration in rats fed diets low in protein and methionine levels. J. Nutr. Sci. Vitaminol.55, 66-74.
• Kłoczko J., Mian M., Wojtukiewicz M. Z., Babiuch L., Bielawiec M., Galar M., 1992. Plasma protein C as a marker of hepatocellular damage in alcoholic liver disease. Haemostasis 22, 340-344.
• Konarski J., Radomska K., Graczyk A., 1993. Cynk - jego rola i funkcje w procesach metabolicznych organizmu człowieka. Mag. Med. 4, 13-19.
• Kozubski W., 2002.Zaburzenia w obrębie układu nerwowego związane ze spożywaniem alkoholu. Przew. Lek. 5, 17-26.
• Lambert J. C., Zhou Z., Kang Y. J., 2003. Supresion of Fas-mediated signaling pathways is involved In zinc inhibition of ethanol induced liver apoptosis. Adv. Exp. Med. Biol.228, 406-412.
• Lewandowicz J., 1993. Zachowanie się cynku w surowicy krwi u chorych z przewlekłym alkoholizmem. Probl. Alkohol. 40, 8-9.
• Lieber C. S., 2002. S-adenosyl-L-methionine: its role in a treatment of liver disorders. Am. J. Clin. Nutr.76, 1183S-1194S.
• Lieber C. S., Lasker J. M., Alderman J., Leo M. A., 1987. The microsomal ethanol oxidizing system and its interaction with other drugs, carcinogens, and vitamins. Ann. N. Y. Acad. Sci. 492, 11-24.
• Lutnicki K., 2006. Zaburzenia równowagi oksydacyjno-antyoksydacyjnej a system ochrony błony śluzowej żołądka szczurów. Rozprawy Naukowe, Akademia Rolnicza, Lublin.
• Lutnicki K., Szpringer E., Marciniak A., 2006. Ethanol evoked oxidation-antioxidation imbalance in rats. Medycyna Wet. 62, 683-685.
• Mallikarjuna K., Nishanth K., Hou C. W., Kuo C. H., Sathyavelu Reddy K., 2009. Effect of exercise training on ethanol-induced oxidative damage in aged rats. Alcohol 43, 59-64.
• Maruyama S., Hirayama C., Yamamoto S., Koda M., Udagawa A., Kadowaki Y., Inoue M., Sagayama A., Umeki K., 2001. Red blood cell status in alcoholic and non-alcoholic liver disease. J. Lab. Clin. Med. 138, 332-337.
• Maser E., 1997. Stress, hormonal changes, alcohol, food constituents and drugs: factors that advance the incidence of tobacco smoke-related cancer? Trends Pharmacol. Sci. 18, 270-275.
• Mason J. B., Choi S. W., 2005. Effects of alcohol on folate metabolism: implications for carcinogenesis. Alcohol Alcohol.35, 235-241.
• Matej-Butrym A., Schabowski J., 2008. Znaczenie witamin w cukrzycy. Fam. Med. Prim. Care Rev. 10, 206-211.
• Okłota M., Niemcunowicz-Janica A., Załuski J., Ptaszyńska-Sarosiek I., 2009. Contribution of ethanol in apoptosis induction . Arch. Med. Sadowej Kryminol. 59, 238-242.
• Olas B., Kedzierska M., Wachowicz B., 2008. Comparative studies on homocysteine and its metabolite-homocysteine thiolactone action in blood platelets in vitro. Platelets 19, 520-527.
• Pasková i., Lávicka M., 1981. Response of chickens to the addition of yeasts of various origin to broiler feed mixtures. Vet. Med. 26, 305-312.
• Pasternak K., Floriańczyk B., Chmielewski M., Marzec Z., 1997. Poziom miedzi i cynku u narkotyzujących się. Biul. Magnezol. 2, 181-183.
• Pedrycz A., Siermontowski P., Polz D., Ciechan A., Kocki J., Puchalska-Kosiecz A., 2011. Immunohistochemical assesment of etanol induced danger of hepatocytes' damage. Curr. Probl. Psychiatry 12, 30-33.
• Popov B., Gadjeva V., Valkanov P., Popova S., Tolekova A., 2003. Lipid peroxidation, superoxide dismutase and catalase activities in brain tumor tissues. Arch. Physiol. Biochem. 111, 455-459.
• Preedy V. R., Peters T. J., 1990. Alcohol and skeletal muscle disease. Alcohol Alcohol. 25, 177-187.
• Reuben A., 2006. Alcohol and the liver. Curr. Opin. Gastroenterol. 22, 263-271.
• Ronis M. J., Hennings L., Stewart B., Basnakian A. G., Apostolov E. O., Albano E., Badger T. M., Petersen D. R., 2011. Effects of long term ethanol administration in a rat total enteral nutrition model of alcoholic liver disease. Am. J. Physiol. Gastrointest. Liver Physiol. 300, G109-G119.
• Rose R. C, Bode A. M., 1993. Biology of free radical scavengers: an evaluation of ascorbate. FASEB J. 7, 1135-1142.
• Ross D., 2004. Quinone reductases multitasking in the metabolic world. Drug Metab. Rev. 36, 639-654.
• Santori C., Ceccanti M., Diacinti D., Attilia M. L., Toppo L., D'Erasmo E., Romagnoli E., Mascia M. L., Cipriani C., Prastaro A., Carnevale V., Minisola S., 2008. Skeletal turnover, bone mineral density, and fractures in male chronic abusers of alcohol. J. Endocrinol. Invest. 31, 321-326.
• Savage D. G., Ogundipe A., Allen R. H., Stabler S. P., Lindenbaum J., 2000. Etiology and diagnostic evaluation of macrocytosis. Am. J. Med. Sci.319, 343-352.
• Seitz H. K., 2000. Alcohol and retinoid metabolism. Gut 47, 748-750.
• Selhub J., Miller J. W., 1991. The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remythylation and transsulfuration of homocysteine. Am. J. Clin. Nutr. 55, 131-138.
• Simon J., Mayer O., Rosolova H., 1999. Effect of folates, vitamin B12 and life style factors on mild hyperhomocysteinemia in a population sample. Cas. Lék.Cesk. 138, 650-653.
• Smith A. D., 2008. The worldwide challenge of the dementias: a role for B vitamins and homocysteine? Food Nutr. Bull. 29, 143-172.
• Sugden P. H., Clerk A., 2006. Oxidative stress and growth-regulating intracellular signaling pathways in cardiac myocytes. Antioxid. Redox Signal. 8, 2111-2124.
• Ścibior-Bentkowska D., Czeczot H., 2009. Cancer cells and oxidative stress. Postepy Hig. Med. Dosw. 63, 58-72.
• Tamura T., Halsted C. H., 1983. Folate turnover in chronically alcoholic monkeys. J. Lab. Clin. Med. 101, 623-628.
• Tucker K. L., Rich S., Rosenberg I., 2000. Plasma vitamin B-12 concentrations relate to intake source in the Framingham Offspring study. Am. J. Clin. Nutr. 71, 514-522.
• Ubbink J. B., Becker P. J., Vermaak W. J., Delport R., 1995. Results of B-vitamin supplementation study used in a prediction model to define a reference range for plasma homocysteine. Clin. Chem.41, 1033-1037.
• Venn B. J., Mann J. I., Williams S. M., Riddell L. J., Chisholm A., Harper M. J., Aitken W., Rossaak J. I., 2002. Assessment of three levels of folic acid on serum folate and plasma homocysteine: a randomised placebo-controlled double-blind dietary intervention trial. Eur. J. Clin. Nutr. 56, 748-754.
• Vermaak W. J., Ubbing J. B., Barnard H. C., Potgieter G. M., 1990. Vitamin B6 nutritional status and cigarette smoking. Am. J. Clin. Nutr. 51, 1058-1061.
• Wannamethee S. G., Shaper A. G., Perry I. J., 2002. Alcohol consumption and the incidence of type II diabetes. J. Epidemiol. Community Health56, 542-548.
• Wassner S. J., Li J. B., Sperduto A., Norman M. E., 1983. Vitamin D deficiency, hypocalcemia, and increased skeletal muscle degradation in rats. J. Clin. Invest.72, 102-112.
• Westerblad H., Place N., Yamada T., 2010. Mechanisms of skeletal muscle weakness. Adv. Exp. Med. Biol. 682, 279-296.
• Włodarek D., 2005. Dietetyka. Format AB, Warszawa.
• Wojtukiewicz M. Z., Sierko C., 2000. Alkohol a nowotwory. Nowotwory 50, 39-47.
• Yokoyama A., Tsutsumi E., Imazeki H., Suwa Y., Nakamura C., Yokoyama T., 2010. Polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and the blood and salivary ethanol and acetaldehyde concentrations of Japanese alcoholic M en. Alcohol. Clin. Exp. Res. 34, 1246-1256.
• Zimatkina T. I., Chernikevich I. P., Zimatkin S. M., Deitrich R. A., 2000. Thiamine status in liver and brain of rats genetically selected for different sensitivity to hypnotic effect of alcohol. Alcohol. Clin. Exp. Res. 24, 1620-1624.