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Nagroda Nobla 2011: dwa rodzaje odporności

Title variants
Nobel Prize 2011: two types of immunity.
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Nagrodę Nobla w dziedzinie fizjologii i medycyny w 2011 r. otrzymali Bruce A. Beutler i Jules A. Hoffmann za odkrycie mechanizmów indukcji odporności wrodzonej oraz Ralph M. Steinman za odkrycie komórek dendrytycznych i ich roli w rozwoju odporności nabytej. Wyniki wieloletnich badań uczonych oraz ich współpracowników zrewolucjonizowały poglądy na podstawy funkcjonowania układu odpornościowego i mechanizmy aktywacji komórek obronnych. Bruce Beutler i Jules Hoffmann scharakteryzowali białkowe receptory odpowiedzialne za rozpoznawanie patogenów i wykazali ich udział w aktywacji komórek odporności wrodzonej, a Ralph Steinman zidentyfikował komórki dendrytyczne i opisał ich unikatową zdolność do indukcji odporności nabytej.
Bruce Beutler, Jules Hoffmann and Ralph Steinman share the Nobel Prize in physiology and medicine. Beutler and Hoffmann elucidated the sensory branch of innate immunity. They discovered and characterized the receptors of innate immune cells involved in the recognition of invading pathogens and analyzed the intracellular signaling pathways leading to development of inflammation and mobilization of the front line of defense against pathogens. Hoffmann concentrated on the role of Toll receptors in Drosophila melanogaster, Beutler on the role of Toll-like receptors in mammals. Steinman investigated mouse dendritic cells and their role in the induction of adaptive immunity, the second line of immune response that comes into play when innate immunity is not enough. The findings of Steinman established dendritic cells as a link between innate and adaptive immunity.
Physical description
  • Zakład Immunologii Instytut Zoologii Wydział Biologii Uniwersytet Warszawski Miecznikowa 1, 02-096 Warszawa, Polska
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