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2012 | 61 | 1 | 51-56
Article title

Alkohol a hemostaza

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EN
Alcohol and hemostasis
Languages of publication
PL EN
Abstracts
PL
Hemostaza zabezpiecza układ krążenia krwi przed jej utratą. Jest to skomplikowany proces, na który wpływa również przyjmowany do organizmu alkohol. Prawie każdy etap tego procesu może być modyfikowany przez etanol, w zależności od wielkości jego dawek. Jest tu istotna aktywacja płytek krwi, ich stopień agregacji, reakcje śródbłonka naczyń krwionośnych, wielkość płytek (objętość), koncentracja fibrynogenu, poziom prostacyklin i wolnych rodników, a także tempo fibrynolizy. W artykule są dyskutowane te zjawiska na tle współczesnego piśmiennictwa.
EN
Hemostasis protects the blood circulatory system from a loss of all blood components. It is a very complicated process which may be modified by ethanol almost at each its phase in dependence on alcohol dose and time length of drinking. In this process following factors are of particular importance: activity and volume of platelets, extent of their activation during aggregation, reactions in blood vessel's epithelium, fibrinogen concentration, levels of prostaglandine and free radicals, and thrombophilic conditions. In this article effects of alcohol on hemostasis are discussed in the context of the contemporary literature data.
Keywords
Journal
Year
Volume
61
Issue
1
Pages
51-56
Physical description
Dates
published
2012
Contributors
  • Miejski Ośrodek Profilaktyki i Terapii Uzależnień, Niciarniana 41, 92-320 Łódź, Polska
  • Praktyka Lekarska, Mehoffera 160 J/1, 03-081 Warszawa, Polska
References
  • Aikens M. L., Grenett H. E., Benza R. L., Tabengwa E. M., Davis G.C., Booyse F.M., 1998. Alcohol-induced upregulation of plasminogen activator and fibrinolytic activity in cultured human endothelial cells. Alcoholism Clin. Exp. Res. 22, 375-381.
  • Belleville J., 2002. The French paradox: possible involvement of ethanol in the protective effects against cardiovascular diseases. Nutrition 18, 173-177.
  • Booyse F. M., Aikens M. L., Grenett H. E., 1999. Endothelial cell fibrinolysis: transcriptional regulation of fibrinolytic protein gene expression (t-PA, u-PA, and PAI-1) by low alcohol. Alcohol Clin Exp. Res. 23, 1119-1124.
  • Budzyński J., Kłopocka M., Świątkowski M., Pulkowski G., Ziołowski M., Kulas A., Kotschy M., 2005. Increased blood coagulation in alcohol dependent male patients during six-month abstinence period. Adv. Clin. Exp. Med. 14, 323-331.
  • Corrao G., Rubbiati L., Bagnardi V., Zambon A., Poikolainen K., 2000. Alcohol and coronary heart disease: a meta-analysis. Addiction 95, 1505-1523.
  • Czerwiec A., 2010. Wpływ kwercetyny na wzrost hodowli fibroblastów oraz stres oksydacyjny wywołany etanolem. Rozprawa doktorska. Śląski Uniwersytet Medyczny, Biblioteka, Sosnowiec, 9-92.
  • Dalle-Done J., Giustarini D., Colombo R., Milzani A., Rossi A., 2005. S-glutathionylation in human platelets by a thiol-disulfide exchange-independent mechanism. Free Rad. Biol. Med. 38, 1501-1510.
  • Deitrich R. A., Bludeau P., Elk M., Baker R., Menez J. F., 1996. Effect of administered ethanol on protein kinase C in human platelets. Alcohol Clin. Exp. Res. 20,1503-1506.
  • Delahousse B., Maillot F., Gabriel I., Schellenberg F., Lamisse F., Gruel Y., 2001. Increased plasma fibrinolysis and tissue-type plasminogen activator:tissue-type plasminogen activator inhibitor ratios after ethanol withdrawal in chronic alcoholics. Blood Coagul. Fibrinolys. 12, 59-66.
  • Engstrom M., Schott U., Reinstrup P., 2006. Ethanol impairs coagulation and fibrinolysis in whole blood: a study performed with rotational thromboelastometry. Blood Coagul. Fibrinolys. 17, 661-665.
  • Essex D.W., 2003. Redox control of platelet aggregation. Biochemistry 42, 129-136.
  • Essex D.W., 2004. Platelet surface glutatione reductase-like activity. Blood 104, 12383-12385.
  • Gacko M., Skrzydlewska E., Worowska A., 1998. Kliniczne aspekty zaburzeń hemostazy u osób nadużywających alkoholu. Post. Nauk Med. 4, 55-58.
  • Grajka W., 2007. Przeciwutleniacze w żywności. Aspekty zdrowotne, technologiczne, molekularne i analityczne. WNT, Warszawa.
  • Guglicci A., 2003. Human plasminogen is highly susceptible to peroxynitrite inactivation. Clin. Chem. Lab. Med. 41, 1064-1068.
  • Hillbom M., Kangasaho M., Kaste M., Numminen H., Vapatalo H., 1985. Acute ethanol ingestion increases platelet reactivity: is there a relationship to stroke? Stroke 16, 19-23.
  • Jelski W., Szmitkowski M., 2008. Wpływ alkoholu etylowego na układ krzepnięcia. Pol. Merk. Lek. 24, 131-133.
  • Karolczak K., Olas B., 2009. Mechanism action of homocysteine and its thiolactone in haemostasis system. Physiol. Res. 58, 1-11.
  • Karolczak K., Olas B., Kołodziejczyk J., 2009. Rola tioli w aktywacji płytek krwi. Post. Biol. Kom. 36, 101-120.
  • Leighton F., Miranda-Rottmann S., Urquiaga I., 2006. A central role of eNOS in the protective effect of wine against metabolic syndrome. Cell Biochem. Funct. 24, 291-298.
  • Leikert J. F., Rathel T. R., Wohlfart P., Cheynier V., Vallmar A. M., Dirsh V. M., 2002. Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells. Circulation 106, 1614-1617.
  • Mehta P., Mehta J., Lawson D., Patel S., 1987. Ethanol stimulates prostacyclin biosynthesis by human neutrophils and potentiates anti-platelet aggregatory effects of prostacyclin. Thrombosis Res. 48, 653-661.
  • Micell M., Alberti L., Bennardini F., Di Simplico P., Seghieri G., Rao G. H. R., Franconi F., 2003. Effect of low doses of ethanol on platelet function in long-life abstainers and moderate-wine drinkers. Life Sci. 73, 1557-1566.
  • Mikhaillidis D. P., Jeremy J. Y., Barradas M. A., 1983. Effect of ethanol on vascular prostacyclin (prostaglandin I-2) synthesis, platelet aggregation, and platelet thromboxane release. Brit. Med. J. 287, 1495-1498.
  • Mukamal K. J., Jadhav P. P., D'Agostino R. B., Massaro J. M., Mittleman M. A., Lipinska I., Sutherland P. A., Matheney T., Levy D., Wilson P. W. F., Ellison R. C., Halit Silbershatz H., Muller J. E., Tofler G. H., 2001. Alcohol consumption and hemostatic factors: analysis of the Framingham Offspring cohort. Circulation 104, 1367-1373.
  • Nielsen V. G., Crow J. P., Zhou F., Parks D. A., 2004. Peroxynitrite inactivates tissue plasminogen activator. Anesthesia Analgesia 98, 1312-1317.
  • Nowak P., Kołodziejczyk J., Wachowicz B., 2004. Peroxynitrite and fibrinolytic system: the effect of peroxynitrite on plasma activity. Mol. Cell Biochem. 267, 141-146.
  • Nowak P., Żbikowska H. M., Ponczek M., Kołodziejczyk J., Wachowicz B., 2007. Different vulnerability of fibrinogen subunits to oxidative/nitrative modifications induced by peroxynitrite: functional consequences. Thrombosis Res. 121, 163-174.
  • Nowak P., Olas B., Wachowicz B., 2010. Stres oksydacyjny w przebiegu hemostazy. Post. Bioch. 56, 239-247.
  • Olas B., Wachowicz B., 2003. Rola reaktywnych form tlenu w płytkach krwi. Post. Biol. Kom. 2, 325-337.
  • Olas B., Wachowicz B., 2007. Role of reactive nitrogen species in blood platelet functions. Platelets 23, 1-11.
  • Olas B., Nowak P., Kołodziejczyk J., Wachowicz B., 2004. The effects of antioxidants on peroxynitrite-induced changes in platelet proteins. Thrombosis Res. 113, 399-406.
  • Pasten C., Grenett H., 2006. Wine, fibrinolysis and health. Revista Medica de Chile 134, 1040-1048.
  • Rabbani M., Nelson E. J., Hoffman P. L., Tabakoff B., 1999. Role of protein kinase C in ethanol-induced activation of adenylyl cyclase. Alcoholism Clin. Exp. Res. 23, 77-86.
  • Renaud S., Dumont E., Godsey F., Suplisson A., Thevenon C., 1979. Platelet functions in relation to dietary fats in farmers from two regions of France. Thrombosis Haemostasis 40, 518-531.
  • Renaud S., McGregor L., Martin J. L., 1984. Influence of alcohol on platelet functions in relation to atherosclerosis. [W:] Diet, diabetes and atherosclerosis. Pozza G. (red.). Raven Press, 177-187.
  • Rimm E. B., Williams P., Fosher K., Cirqui M., Stampfer M. J., 1999. Moderate alcohol intake and lower coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. Brit. Med. J. 319, 1523-1528.
  • Ross J. A., Kasum C. M., 2002. Dietary flavonoids: bioavailability, metabolic effect, and safety. Ann. Rev. Nutr. 22, 19-34.
  • Rubin R., 1989. Ethanol interferes with collagen-induced platelet activation by inhibition of arachidonic acid mobilization. Arch. Biochem. Biophys. 287, 99-113.
  • Rubin R.., 1999. Effects of ethanol on platelet function. Alcoholism Clin. Exp. Res. 23, 1114-1118.
  • Ruf J. C., 2004. Alcohol, wine and platelet function. Biol. Res. 37, 209-215.
  • Salem R. O., Laposata M., 2006. Activation and impairment of platelet function in vitro by fatty acid ethyl ester, a nonoxidative ethanol metabolite: effects of fatty acid esters on human platelets. Alcoholism Clin. Exp. Res. 30, 2079-2088.
  • Sierksma A., van der Gaag M. S., Kluft C., Hendriks H. F. J., 2002. Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels; a randomized, diet-controlled intervention study. Eur. J. Clin. Nutr. 56, 1130-1136.
  • Suhonen O., Aromaa A., Reunanen A., Knekt P., 1987. Alcohol consumption and sudden coronary death in middle-aged Finnish men. Acta Med. Scand. 221, 335-341.
  • Tyurin K. V., Khanin M. A., 2006. Hemostasis as an optimal system. Mathem. Biosci. 204, 167-184.
  • Vadseth C., Souza J. M., Thomson L., Seagraves A., Nagaswami C., Scheiner T., Torbet J., Vilaire G., Bennet J. S., Murciano J. C., Muzykantov V., Penn M. S., Hazen S. L., Weasel J. W., Ischiropoulos H., 2004. Pro-thrombotic state induced by post-translational modification of fibrinogen by reactive nitrogen species. J. Biol. Chem. 279, 8820-8826.
  • Van Der Woude H., GLiszczyńska-Świgło A., Struijs K., Smeets A., Alink G. M., Rietjens I. M. C. M., 2003. Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans. Cancer Lett. 200, 41-47.
  • Wachowicz B., Olas B., Zbikowska H. M., Buczyński A., 2002. Generation of reactive oxygen species in blood platelets. Platelets 13, 175-182.
  • Wakabayashi I., Marumo M., 2002. Ethanol inhibits store-operated Ca2+ entry of platelets. Pharmacol. Toxicol. 90, 226-228.
  • Wallestedt S., Cederblad G., Korsan-Bengtsen K., Olsson R., 1997. Coagulation factors and other plasma proteins during abstinence after heavy alcohol consumption in chronic alcoholics. Scand. J. Gastreoenterol. 12, 649-655.
  • Wannamethee S. G., Lowe G. D., Shaper G., 2003. The effects of different alcoholic drinks on lipids, insulin and haemostatic and inflammatory markers in older men. Thrombosis Haemostasis 90, 1080-1087.
  • Zhang Q. H., Das K., Siddiqui S., Myers A. K., 2000. Effects of acute, moderate ethanol consumption on human platelet aggregation in platelet-rich plasma and whole blood. Alcoholism Clin. Exp. Res .24, 528-534.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-ksv61p51kz
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