Obiektywne spojrzenie na zły aldehyd octowy

• Authors: Krzysztof Kumański , Agnieszka Kamińska

Title variants

EN

The objective look on "bad" acetaldehyde

• Languages of publication: PL EN

Abstracts

PL

Gdy w organizmie pojawi się znaczna ilość egzogennego alkoholu włącza się w jego przemiany główna ścieżka metaboliczna realizująca się poprzez utlenianie go do aldehydu octowego. Układ dehydrogenaza alkoholowa/dehydrogenaza aldehydowa gra tu główną rolę poza zespołem MEOS, katalazy i degradacji nieoksydacyjnej. Aldehyd octowy jest znacznie bardziej szkodliwy od samego etanolu, szybkość jego degradacji zależy więc i od ilości wypitego alkoholu i od okresu trwania chronicznego go przyjmowania. Zarówno dehydrogenaza alkoholowa (ADH) jak i aldehydowa (ALDH) ujawniając polimorfizm zależny od rodzaju organu ujawniają też różną intensywność metabolizowania etanolu.

EN

High content of ethyl alcohol in the organism turns on the main catabolic pathway of ethanol leading to its oxidation to acetaldehyde. In this process, an important role is played by the complex: alcohol dehydrogenase/acetaldehyde dehydrogenase (ADH/ADLH), apart from MEOS (microsomal ethanol oxidizing system), catalase activity and nonoxidative degradation processes. The acetaldehyde is considerable more adverse for tissues than ethanol oneself. Thus, its decomposition reaction should be fast but dependent on the amount of drunk and length of its consumption. The both dehydrogenases reveal some polymorphism connected with different metabolic intensity, dependent upon the kind of tissue or organ.

• Journal: Kosmos
• Year: 2012
• Volume: 61
• Issue: 1
• Pages: 37-50

Dates

published

2012

Contributors

author

Krzysztof Kumański

• Miejski Ośrodek Profilaktyki i Terapii Uzależnień, ul. Niciarniana 41, 92-320 Łódź, Polska

author

Agnieszka Kamińska

• Praktyka Lekarska, ul Mehoffera 160 J/1, 03-081 Warszawa, Polska

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