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Journal
2012 | 61 | 1 | 37-50
Article title

Obiektywne spojrzenie na zły aldehyd octowy

Content
Title variants
EN
The objective look on "bad" acetaldehyde
Languages of publication
PL EN
Abstracts
PL
Gdy w organizmie pojawi się znaczna ilość egzogennego alkoholu włącza się w jego przemiany główna ścieżka metaboliczna realizująca się poprzez utlenianie go do aldehydu octowego. Układ dehydrogenaza alkoholowa/dehydrogenaza aldehydowa gra tu główną rolę poza zespołem MEOS, katalazy i degradacji nieoksydacyjnej. Aldehyd octowy jest znacznie bardziej szkodliwy od samego etanolu, szybkość jego degradacji zależy więc i od ilości wypitego alkoholu i od okresu trwania chronicznego go przyjmowania. Zarówno dehydrogenaza alkoholowa (ADH) jak i aldehydowa (ALDH) ujawniając polimorfizm zależny od rodzaju organu ujawniają też różną intensywność metabolizowania etanolu.
EN
High content of ethyl alcohol in the organism turns on the main catabolic pathway of ethanol leading to its oxidation to acetaldehyde. In this process, an important role is played by the complex: alcohol dehydrogenase/acetaldehyde dehydrogenase (ADH/ADLH), apart from MEOS (microsomal ethanol oxidizing system), catalase activity and nonoxidative degradation processes. The acetaldehyde is considerable more adverse for tissues than ethanol oneself. Thus, its decomposition reaction should be fast but dependent on the amount of drunk and length of its consumption. The both dehydrogenases reveal some polymorphism connected with different metabolic intensity, dependent upon the kind of tissue or organ.
Keywords
Journal
Year
Volume
61
Issue
1
Pages
37-50
Physical description
Dates
published
2012
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