Alkohol a glutation

• Authors: Agnieszka Kamińska , Krzysztof Kumański

Title variants

EN

Alcohol and glutathione

• Languages of publication: PL EN

Abstracts

PL

Glutation jest jednym z najsilniej działających antyoksydantów, a alkohol w środowisku komórki zaburza prawidłowe procesy systemu oksydacyjno-redukcyjnego, wpływając niekorzystnie m.in. na stosunek GSH/GSSG. Powoduje to liczne zaburzenia prawie we wszystkich tkankach i narządach, szczególnie w wątrobie, płucach, mięśniach szkieletowych, mięśniu sercowym, również w procesie apoptozy i mechanizmach odpornościowych komórki. Zjawiska te stają się bardziej widoczne u ludzi w starszym wieku, u których możliwości obronne tkanek są już wyraźnie osłabione, zwłaszcza w odniesieniu do aktywności enzymów glutationowych.

EN

Glutathione is one of the strongest cellular antioxidants. Presence of ethyl alcohol in cells influences disadvantageously glutathione redox GSH/GSSG equilibrium and evokes numerous disorders in all tissues and organs, particularly in liver, lung, skeletal muscles, heart muscles, and in apoptosis and immunity processes. These disorders are more evident in the older people owing to the lower efficiency of their defense systems.

• Journal: Kosmos
• Year: 2012
• Volume: 61
• Issue: 1
• Pages: 105-120

Dates

published

2012

Contributors

author

Agnieszka Kamińska

• Praktyka Lekarska, Mehoffera 160 J/1, 03-081 Warszawa, Polska

author

Krzysztof Kumański

• Miejski Ośrodek Profilaktyki i Terapii Uzależnień, Niciarniana 41, 92-320 Łódź, Polska

References

• Addolorato G., Gasbarrini A., Marcoccia S., Simoncini M., Baccarini P., Vagni G., Grieco A., Sbriccoli A., Granato A., Stefanini G.F., Gasbarrini G., 1997. Prenatal exposure to ethanol in rats: effects on liver energy level and antioxidant status in mothers, fetuses, and newborns. Alcohol 14, 569-573.
• Ames B. N., Shigenaga M. K., Hagen M., 1993. Oxidants, antioxidants, and generative diseases of aging. Proc. Natl. Acad. Sci. USA 90, 7915-7922.
• Amini S. A., Dunstan R. H., Dunkley P. R., Murdoch R.N., 1996. Oxidative stress and the fetotoxicity of alcohol consumption during pregnancy. Free Radical Biol. Med. 21, 357-365.
• Arrigo A. P. 1999. Gene expression and the thiol redox state. Free Radical Biol. Med. 7, 936-944.
• Bai C., Brown L. A., Jones D. P., 1994. Glutathione transport by type II cells in perfused rat lung. Am. J. Physiol. 267, L447-L455.
• Bailey S. M., Patel V. B., Young T. A., Asayama K., Cunningham C. C., 2001. Chronic ethanol consumption alters the glutathione/glutathione peroxidase-1 system and protein oxidation status in rat liver. Alcoholism Clin. Exp. Res. 25, 726-733.
• Baker R., Jerrells T., 1993. Recent developments in alcoholism: immunological aspects.Recent Develop.Alcoholism Sociol. 11, 249-271.
• Bald E., 2003. Homocysteina, niegdyś egzotyczny metabolit. [W:] Biotiole w warunkach fizjologicznych, patologicznych i w terapii. Włodek I. (red.). Wyd. Uniw. Jagiellońskiego, 73-97.
• Ballatori N., Krance S. M., Marchan R., Harmmond C. L., 2009. Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology. Mol. Aspects Med. 30, 13-28.
• Bartosz G., 1993. Metabolizm glutationu. Post. Bioch. 39, 32-37.
• Bartosz G., 1998. Rola reaktywnych form tlenu w apoptozie. Post. Bioch. 44, 22-31.
• Bartosz G., 2003. Druga twarz tlenu. Wolne rodniki w przyrodzie. PWN, Warszawa.
• Baughman R., Roselle G., 1987. Surfactant deficiency with decreased opsonic activity in a guinea pig model of alcoholism. Alcoholism Clin. Exp. Res. 11, 261-264.
• Bilska A., Krawczyk A., Włodek L., 2007. Różne oblicza biologicznej roli glutationu. Post. Hig. Med. Dośw. 61, 438-453.
• Bindu M. P., Sreekanth K. S., Annamali P. T., Augusti K. T., 2002. Effect of S-allyl cysteine sulphoxide on lipid metabolism and free radical scavengers in alcohol-fed rats. Curr. Sci. 82, 628-631.
• Boda D., Nemeth I., Pinter S., 1998. Surface tension, glutathione content and redox ratio of the tracheal aspirate fluid of premature infants with IRDS. Biol. Neonate 74, 281-288.
• Brooks P. J., 1997. DNA damage, DNA repair, and alcohol toxicity - a review. Alcoholism Clin. Exp. Res. 21, 1073-1082.
• Brown L. A., 1994. Glutathione protects signal transduction in type II cells under oxidative stress. Am. J. Physiol. 266, L172-L177.
• Brown L. A., Perez J. A., Harris F. L., Clark R. H., 1996. Glutathione supplements protect preterm rabbits from oxidative lung injury. Am. J. Physiol. 270, L446-L451.
• Brown L. A., Harris F. L., Bechara R., Guidot D. M., 2001. Effect of chronic ethanol ingestion on alveolar type II cell: glutathione and inflammatory mediator-induced apoptosis. Alcoholism Clin. Exp. Res. 25,1078-1085.
• Burnham E. L., Brown L. A., Halls L., Moss M., 2003. Effects of chronic alcohol abuse on alveolar epithelial barrier function and glutathione homeostasis. Alcoholism Clin. Exp. Res. 27, 1167-1172.
• Cahill A., Hershman S., Davies A., Sykora P., 2005. Ethanol feeding enhances age related deterioration of the rat hepatic mitochondrian. Am. J. Physiol. Gastrointestinal Liver Physiol. 289, G.1115-G.1123.
• Cai J., Jones D. P., 1998. Superoxide in apoptosis. Mitochondrial generation triggered by cytochrome c loss. J. Biol. Chem. 273, 1141-11404.
• Carbone D. L., Doorn J. A., Kiebler Z., Petersen D. R., 2005. Cysteine modification by lipid peroxidation products inhibits protein disulfide isomerase. Chem. Res. Toxicol. 18, 1324-1331.
• Chandra R., Aneja R., Rewal C., Konduri R., Das S. K., Agarwal S., 2000. An opium alkaloid-papaverine ameliorates ethanol-induced hepatotoxicity: diminution of oxidative stress. Indian J. Clin. Biochem.15, 155-160.
• Colton C. A., Snell-Callanan J., Chernyshev O. N., 1998. Ethanol induced changes in superoxide anion and nitric oxide in cultured microglia. Alcoholism Clin. Exp. Res. 2, 710-716.
• Corradi M., 2003. Aldehydes and glutathione in exhaled breath condensate of children with asthma exacerbation.Am. J. Resp. Critical Care Med. 167, 395-399.
• Czuczejko J., Halota W., Zachara B. A., Staubach--Topczewska E. 2002. Plasma selenium concentration, glutathione peroxidase and glutathione S-transferase activities in patients with chronic liver diseases. Pol. Merk. Lek.13, 312-315.
• Czuczejko J., Zachara B. A., Staubach-Topczewska E., Halota W., Kedziora J., 2003. Selenium, glutathione and glutathione peroxidases in blood of patients with chronic liver diseases. Acta Biochim. Pol.50, 1147-1154.
• Das S. K, Vasudevan D. M., 2005. Effect of ethanol on liver antioxidant defense system: a dose dependent study. Indian J. Clin. Biochem. 20, 80-84.
• Demasi M., Shringapure R., Davies K. J., 2001. Glutathione of the proteasome is enhanced by proteolytic inhibitors. Arch. Biochem. Biophys. 389, 254-263.
• Devi B. G., Henderson G. I., Frosto T. A., Schenker S., 1993. Effect of ethanol on rat fetal hepatocytes: studies on cell replication, lipid peroxidation and glutathione. Hepatology 18, 648-659.
• Dorshow J.H., Akman S., Chu F.F., Esworthy S., 1990. Role of the glutathione-glutathione peroxidase cycle in the cytoxicity of the anticancer quinones. Pharmacol. Therapeutics 47, 359-367.
• Duncan K., Harris S., Ardies C. M., 1997. Running exercise may reduce risk of lung and liver cancer by inducing activity of antioxidant and phase II enzymes. Cancer Lett. 116, 151-158.
• Dziubek K., 2005. Badania nad wpływem różnych czynników chemicznych i fizycznych na stężenie glutationu zredukowanego (GSH) i utlenionego (GSSG) w wybranych organach Rana esculenta L. w okresie zimowania. Wyd. Nauk. Akademii Pedagogicznej w Krakowie, Kraków.
• Ebrahim S. H., Luman E. T., Floyd R. L., Murphy C. C., Bennett E. M., Boyle C. A., 1998. Alcohol consumption by pregnant women in the United States during 1988-1995. Am. J. Obstetrics Gynecol. 92, 187-192.
• Ebrahim S. H., Diekman S. T., Floyd R. L., Decoufle P., 1999. Comparison of binge drinking among pregnant and nonpregnant women in United States, 1991-1995. Am. J. Obstetrics Gynecol. 180, 1-7.
• Effros R. M., Casaburi R., Su J., Dunning M., Torday J., Biller J., Shaker R., 2006. The effects of volatile salivary acids and bases on exhaled breath condensate pH. Am. J. Resp. Critical Care Med. 173, 386-392.
• Ekstrom G., Ingelman-Sundberg M., 1989. Rat liver microsomal NADPH - supported oxidase activity and lipid peroxidation dependent on ethanol - inducible cytochrome P 450. Biochem. Pharmacol. 38, 1313-1319.
• El-Sayed M. S., Ali N., El-Sayed A. Z., 2005. Interaction between alcohol and exercise: physiological and haematological implications. Sports Med. 35, 257-269.
• Fasano W. J., Sweeney L. M., Mawin M. P., Nabb D., Szostek B., Buck R. C., Gargas M. L., 2009. Kinetics of 8-2 fluorotelomer alcohol and its metabolites, and liver glutathione status following daily oral dosing for 45 days in male and female rats. Chem. Biol. Interactions 181, 281-295.
• Foreman M. G., Hoor T. T., Brown L. A., Moss M., 2002. Effects of chronic hepatic dysfunction on pulmonary glutathione homeostasis.Am. J. Resp. Critical Care Med. 26, 1840-1845.
• Forman H., Skelton D., 1990. Protection of alveolar macrophages from hyperoxia by gamma-glutamyl transpeptidase. Am. J. Physiol. (Lung Cell Molecular Physiol). 259, L102-L107.
• Gauthier T. W., Ping X. D., Harris F. L., Wong M., Elbahesh H., Brown L. A., 2005. Fetal alcohol exposure impairs alveolar macrophage function via decreased glutathione availability. Pediatric Res. 57, 76-81.
• Gąsior K., Chodkiewicz J. (red.), 2010. Leczenie alkoholików i członków ich rodzin. Wydawnictwo Jedność, Kielce.
• Gendźwiłł A., 2007. Reaktywne formy tlenu i hipokreatywność naczyń we wstrząsie septycznym. Pol. Merk. Lek. 23, 284-287.
• Go Y. M., Jones D. P., 2005. Intracellular proatherogenic events and cell adhesion modulated by extracellular thiol/disulfide redox state. Circulation 111, 2973-2980.
• Greenberg S., Zhao X., Hua L., Wang J., Nelson S., Ouyang J., 1999. Ethanol inhibits lung clearance of Pseudomonas aeruginosa by a neutrophil and nitric oxide-dependent mechanism in vivo. Alcoholism Clin. Exp. Res. 23, 735-744.
• Grigg J., Barber A., Silverman M., 1993. Bronchoalveolar lavage fluid glutathione in intubated premature infants. Arch. Disease Childhood69, 49-51.
• Guidot D., Moss M., Holguin F., Lois M., Brown L., 1999. Ethanol ingestion impairs alveolar epithelial glutathione homeostasis and function, and predisposes to endotoxin-mediated acute lung injury. Chest 116, 82S-83S.
• Guidot D., Brown L., 2000. Mitochondrial glutathione replacement restores surfactant synthesis and secretion in alveolar epithelial cells of ethanol-fed rats. Alcoholism Clin. Exp. Res. 24, 1070-1076.
• Gul M., Kutay F. Z., Temocin S., Hanninen O. 2000. Cellular and clinical implications of glutathione. Indian J. Exp. Biol. 38, 625-634.
• Gunduz F., Senturk U. K., Kuru O., Aktekin B., Aktekin M. R. 2004. The effect of one year's swimming exercise on oxidant stress and antioxidant capacity in aged rats. Physiol. Res. 53, 171-176.
• Gupta S., Pandey R., Katyal R., Aggarwal H. K., Aggarwal R. P., Aggarwal S. K., 2003. Lipid peroxidation levels and antioxidant status in alcoholic liver disease. Indian J. Clin. Biochem. 20, 67-71.
• Halsted C. H., Villanueva J. A., Devlin A. M., Chandler C. J. 2002. Metabolic interactions of alcohol and folate. Am. Soc. Nutr. Sci. 132, 2367S-2372S.
• Hansen J. M., Choe H. S., Carney E. W., Harris C., 2001. Differential antioxidant enzyme activities and glutathione content between rat and rabbit conceptuses. Free Rad. Biol. Med. 30, 1078-1088.
• Haouzi D., Lekehal M., Tinel M., Vadrot N., Caussanel L., Letteron P., Moreau A., Feldmann G., Fau D., Pessayre D., 2001. Prolonged, but not acute, glutathione depletion promotes Fas-mediated mitochondrial permeability transition and apoptosis in mice. Hepatology 33, 1181-1188.
• Harman D., 1986. Free radical theory of aging: role of free radicals in the origination and evolution of life, aging and disease process. [W:] Biology of aging. Johnson J., Walford J.V, Harman, J. Miquel R. (red). New York Liss, New York, 255-275.
• Helewski K. J., Kowalczk-Ziomek J., Konecki J., 2006. Apoptoza i martwica - dwie drogi jednego celu. Wiad. Lek. 59, 679-684.
• Henderson G. I., Devi B. G., Perez A., Schenker S., 1995. In utero ethanol exposure elicits oxidative stress in the rat fetus. Alcoholism Clin.Exp. Res. 19,714-720.
• Hentze H., Kunstle G., Volbracht C., Ertel W., Wendel A., 1999. CD95-mediated murine hepatic apoptosis requires an intact glutathione status. Hepatology 30, 177-185.
• Hentze H., Latta M., Kunstle G., Lucas R., Wendel A., 2003. Redox control of hepatic cell death. Toxicol. Lett.139, 111-118.
• Hirano T., Kaplowitz N., Tsukamoto H., Kamimura S., Fernandez-Checa J. C., 1992. Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver diseases in rats. Hepatol. 16, 1423-1427.
• Holguin F., Moss I., Brown L. A, Guidot D. M., 1998. Chronic ethanol ingestion impairs alveolar type II cell glutathione homeostasis and function and predisposes to endotoxin-mediated acute edematous lung injury in rats. J. Clin. Invest. 101, 761-768.
• Husain K., Somani S. M., 1997a. Interaction of exercise training and chronic ethanol ingestion on hepatic and plasma antioxidant system in rat. J. Appl. Toxicol. 17, 189-194.
• Husain K, Somani S. M.. 1997b. Interaction of exercise and ethanol on hepatic and plasma antioxidant system in rat. Pathophysioogy 4, 69-74.
• Hwang C., Sinksey A. J, Lodish H. F., 1992. Oxidized redox state of glutathione in the endoplasmic reticulum. Science 257, 1496-1502.
• Jackson A. S., Sandrini A., Campbell C., Chow S., Thomas P. S., H. Yates D. H., 2007. Comparison of biomarkers in exhaled breath condensate and bronchoalveolar lavage.Am. J. Resp.Critical Care Med. 175, 222-227.
• Ji L. L., 1993. Antioxidant enzyme response to exercise and aging. Med. Sci. Sports Exercise25, 225-231.
• Ji L.L., 1995. Exercise and oxidative stress: role of the cellular antioxidant systems. Exercise Sport Sci. Rev.23, 135-166.
• Jocelyn P. C., 1972. Biochemistry of the SH groups. Academic Press, London, New York.
• Jones D. P., 2002. Redox potential of GSH/GSSG couple: assay and biological significance. Methods Enzymol. 348, 93-112.
• Jones D. P., 2006. Extracellular redox state: refining the definition of oxidative stress in aging. Rejuvenation Res.9,169-181.
• Jones D. P., Carlson J. L., Mody V. C., Cai J., Lynn M. J., Sternberg P., 2000. Redox state of glutathione in human plasma. Free Rad. Biol. Med. 28,625-635.
• Jurczuk M., Moniuszko-Jakoniuk J., Rogalika J., 2006. Glutathione related enzyme activity in liver and kidney of rats exposed to cadmium and ethanol. Pol. J. Env. Studies 15, 861-868.
• Kakarla P, Kesireddy S. R., 2005. Age and ethanol-induced oxidative stress: impact of exercise training on glutathione metabolism in rat myocardium. Free Rad. Res. 39, 1211-1217.
• Kamińska A., 2011. Dyskretny związek biochemiczny - glutation. Salubritas, Polska 2, 69-87.
• Kaplowitz N., Aw T. Y., Ookhtens M., 1985. The regulation of hepatic glutathione. Ann. Rev. Pharmacol. Toxicol. 25, 715-744.
• Karolczak K., Olas B., Kołodziejczyk J., 2009. Rola tioli w aktywacji płytek krwi. Post. Biol. Kom. 36, 101-120.
• Karwicka E., 2010. Rola glutationu w oporności wielolekowej nowotworów. Post. Biol. Kom. 37, 323-341.
• Kim Y. C., Kim Y. S., Sohn Y. R., 2003. Effect of age increase on metabolism and toxicity of ethanol in female rats. Life Sci. 74, 509-519.
• Klatt P., Lamas S., 2000. Regulation of protein function by S-glutathione in response to oxidative and introsative stress. Eur. J. Biochem. 267, 4928-4944.
• Knapen M. F., Zusterzeel P. L., Peters W. H., Steegers E. A., 1999. Glutatione and glutathione-related enzymes in reproduction. Eur. J. Obestric Reprod. Biol. 82, 171-184.
• Knecht K. T., Thurman R. G., Mason R. P., 1993. Role of superoxide and trace transition metals in production of a-hydroxylethyl radical from ethanol by microsomes from alcohol dehydrogenase deficient deermice. Arch. Biochem. Biophys. 303, 339-348.
• Kołątaj A., 1986. Fizjologiczna rola grup tiolowych. Kieleckie Studia Biol. Kielce 3, 127-167.
• Kostowski W., Wald I. (red.), 1991. Działanie biologiczne alkoholu etylowego. PWN, Warszawa.
• Książek K., 2010. Stres oksydacyjny jako uniwersalna przyczyna starzenia się - od somatycznych komórek człowieka do jednokomórkowych drożdży i prokariotycznych komórek bakterii. Post. Biochem. 56, 260-268.
• Kumański K., Pisarski A., 2010. Zintegrowany model leczenia osób uzależnionych od alkoholu. [W:] Leczenie alkoholików i członków ich rodzin. Gąsior K., Chodkiewicz J. (red.). Wyd. Jedność, Kielce, 180-186.
• Kumaran S. V., Arulmathi K., Srividhya R., Kalaiselvi P., 2008. Repletion of antioxidant status by EGCG and retardation of oxidative damage induced macromolecular anomalies in aged rats. Exp. Gerontol. 43, 176-183.
• Leeuwenburgh C., Ji L. L., 1995. Glutathione depletion in rested and exercised mice: biochemical consequence and adaptation. Arch. Biochem. Biophys.316, 941-949.
• Leeuwenburgh C., Fiebig R., Chandwaney R., Ji L. L., 1994. Aging and exercise training in skeletal muscle: responses of glutathione and antioxidant enzyme systems. Am. J. Physiol. 267, R439-R445.
• Lester B. M., El Sohly M., Wright L. L., Smeriglio V. L., Verter J., Bauer C. R., Shankaran S., Bada H. S., Walls H. H., Huestis M. A., Finnegan L. P., Maza P. L., 2001. The maternal lifestyle study: drug use by meconium toxicology and maternal self-report. Pediatrics 107, 309-317.
• Liczmański A. E., 1988. Toksyczność tlenu. Post. Bioch. 34, 273-310.
• Lieber C. S., 1993. Biochemical factors in alcoholic liver disease. Seminars Liver Diseases 13, 136-153.
• Lieber C. S., 1995. Medical disorders of alcoholism. New Engl. J. Med.333, 1058-1065.
• Loeb G., Skelton D., Coates T., Forman H., 1998. Role of selenium-dependent glutathione peroxidase in antioxidant defenses in rat alveolar macrophages. Exp. Lung Res. 14 (Suppl.), 921-936.
• Loguercio C., Clot P., Albano E., Argenzio F., Grella A., De Girolamo V., Delle Cave M., Del Vecchio Bianco C., Nardi G., 1997. Free radicals and not acetaldehyde influence the circulating levels of glutathione after acuteor chronic alcohol abuse: in vivo and in vitro studies. Italian J.Gastroenterol. Hepatol. 29, 168-173.
• Lu S. C., 2000. Regulation of glutathione synthesis. Curr. Top Cell Regulation 36, 95-116.
• Łuczaj W., Waszkiewicz E., Skrzydlewska E., Roszkowska-Jakimiec W., 2004. Green tea protection against age-dependent ethanol-induced oxidative stress. J. Toxicol. Environ. Health A 67, 595-606.
• Łukaszewicz-Hussain A., 2003. Rola glutationu i enzymów z nim związanych w procesach antyoksydacyjnych organizmu. Med. Pracy 54, 473-479.
• Mallikarjuna K., Nishanth K., Reddy K. S., 2007. Hepatic glutathione mediated antioxidant system in ethanol treated rats: decline with age. Pathophysiology 14, 17-21.
• Mallikarjuna K., Shanmugam K. R., Nishanth K., Ming-Cieh W., Chein-Wen H., Chia-Hua K., Reddy K. S., 2010. Alcohol-induced deterioration in primary antioxidant and glutathione family enzymes reversed by exercise training in the liver of old rats. Alcohol 44, 523-529.
• Matuso M., 1993. Age-related alterations in antioxidative defense. [W:] Free radicals in aging. Yu B. P. (red.). CRC Press, Boca Raton, 143-181.
• McVicker B. L., Tuma P. L., Kharbanda K. K., Serene M. L., Dean J., 2009. Relationship between oxidative stress and hepatic glutathione levels in ethanol-mediated apoptosis of polarized hepatic cells. Tuma World J. Gastroenterol. 15, 2609-2616.
• Meir P., Seitz H. K., 2008. Age, alcohol metabolism and liver disease. Cur. Opin. Clin. Nutr. Metab. Care 11, 21-26.
• Meister A., Anderson M. 1983. Glutathione. Ann. Rev. Biochem. 52, 711-760.
• Miller W. R., Munoz R. F., 2006. Picie kontrolowane. Wyd. Eduk. PARPAMEDIA, Warszawa, 5-150.
• Mohan I. V., Jagroop I. A., Mikhailidis D. P., Stansby G. P., 2008. Homocysteine activates platelets in vitro. Clin. Appl. Thromb. Hemost. 14, 8-18.
• Moss M., Guidot D. M., Wong-Lambertina M., Ten Hoor T., Perez R. L., Brown L. A. 2000. The effects of chronic alcohol abuse on pulmonary glutathione homeostasis. Am. J. Resp. Critical Care Med. 161, 414-419.
• Moos R. H., Brennan P. L., Schutte K. K., Moos B. S., 2004. High-risk alcohol consumption and late-life alcohol use problems. Am. J. Public Health 94,1985-1991.
• Moriarty S. E, Shah J. H., Lynn M., Jiang S., Openo K., Jones D. P., 2003. Oxidation of glutathione and cysteine in human plasma associated with smoking. Free Radical Biol. Med. 35, 1582-1588.
• Nicholas A. S. H, Jun R., 2003. Short - term acetaldehyde exposure depresses ventricular myocyte contraction: role of cytochrome P 450 oxidase, xynthine oxidase and lipid peroxidation. Alcoholism Clin. Exp. Res. 27, 577-583.
• Nordmann R., Ribiere C., Rouach H., 1992. Implication of free radical mechanism in ethanol-inducted cellular injury. Free Radical Biol. Med.12, 219-240.
• Nutt D. J., Peters T. J., 1994. Alcohol - The Drug. Brit. Med. Bull. 1, 5-7.
• Oh S. I., Kim C. I., Chun H. J., Park S. C. 1997. Chronic ethanol consumption affects glutathione status in rat liver. J. Nutr. 128, 758-763.
• Ojeda M. L., Nogales F., Vazquez B., Delgado M. J., Murillo M. L., Carreras O., 2009. Alcohol, gestation and breastfeeding: selenium as an antioxidant therapy. Alcohol Alcoholism 44, 272-277.
• Okłota M., Niemcumowicz-Janica A., Załuski J., Ptaszyńska-Sarosiek J., 2009. Udział etanolu w indukcji procesu apoptozy. Arch. Med. Sądowej Kryminalnej 59, 238-242.
• Omidvari K., Casey R., Nelson S., Olariu R., Shellito J., 1998. Alveolar macrophage release of tumor necrosis factor-α in chronic alcoholics without liver disease. Alcoholism Clin. Exp. Res. 22, 567-572.
• Perla-Kajan J., Twardowski T., Jakubowski H., 2007. Mechanisms of homocysteine toxicity in humans. Amino Acids 32, 561-572.
• Piekutowski K., Makarewicz R., Zachara B. A., 2007. The antioxidative role of selenium in pathogenesis of cancer of the female reproductive system. Neoplasma54, 374-378.
• Pietarinen P., Raivio K., Devlin R., Crapo J., Chang L., Kinnula V., 1995. Catalase and glutathione reductase protection of human alveolar macrophages during oxidant exposure in vitro. Am. J. Resp. Cell Mol. Biol. 13, 434-441.
• Polavarapu R., Spitz D. R., Sim J. E., Follansbee N. H., Oberley L. W., Rahemtulla A., 1998. Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil. Hepatology 27, 1317-1323.
• Pushpalata K., Nishanth K., Sathyavelu Reddy K. 2007. Myocardial antioxidant status and oxidative stress after combined action of exercise training and ethanol in two different age groups of male albino rats. Acta Biol. Hung. 58, 173-185.
• Rahman I., Adcock I. M., 2006. Oxidative stress and redox regulation of lung inflammation in COPD. Eur. Resp. J.28, 219-242.
• Rajkovič I. A., Williams R., 1985. Inhibition of neutrophil function by hydrogen peroxide. Effect of SH- group-containing compounds. Biochem. Pharmacol.34, 2083-2090.
• Ramachandran V., Perez A., Chen J., Senthil D., Schenker S., Henderson G. I., 2001. In utero ethanol exposure causes mitochondrial dysfunction, which can result in apoptotic cell death in fetal brain: a potential role for 4-hydroxynonenal. Alcoholism Clin. Exp.Res. 25, 862-871.
• Reyes E., Ott S., Robinson B., 1993. Effects of in utero administration of alcohol on glutathione levels in brain and liver. Alcoholism Clin. Exp. Res. 17, 877-881.
• Rikans L. E., Snowden C. D., 1989. Effects of acute ethanol administration on female rat liver as a function of aging. Life Sci. 45, 1373-1379.
• Ristoff E., Larsson A., 2007. Inborn errors in the metabolism glutathione. Orphanet J. Rare Disord. 2, 16-24.
• Rodriguez J. F., Cordero J., Chantry C., Gonzales S., Rivera C., Febo I., Colon A., Diaz C., 1998. Plasma glutathione concentrations in children infected with human immunodeficiency virus. Pediatr. Infect. Disease J. 17, 236-241.
• Ronach H., Faraccioli V., Gentil M., French S. W., Morimoto M., Nordmann R., 1997. Effect of chronic ethanol feeding on lipid peroxidation and protein oxidation in relation to liver pathology. Hepatology 25, 351-355.
• Samiec P. S., Drews-Botsch C., Flagg E. W., Kurtz J. C., Sternberg P. Jr, Reed R. L., Jones D. P., 1998. Glutathione in human plasma: decline in association with aging, age-related macular degeneration, and diabetes. Free Radical Biol. Med. 24, 699-704.
• Samochowiec S., 2007. Czynniki genetyczne w uzależnieniu alkoholowym. Neuropsych. Neuropsychol. 2, 54-56.
• Savarino L., Granchi D., Ciapetti G., Cenni E., Ravaglia G., Forti P., 2001. Serum concentrations of zinc and selenium in elderly people: results in healthy nonagenarians/centenarians. Exp. Gerontol. 36, 327-339.
• Schafer F. Q., Buettner G. R., 2001. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radical Biol. Med. 30,1191-1212.
• Schulz J. B., Lindenau J., Seyfried J., Dichgans J., 2000. Glutathione, oxidative stress and neurodegeneration. Eur. J. Biochem. 267, 4904-4911.
• Sen C. K., Parker L., 2000. Thiol homeostasis and supplements in physical exercise. Am. J. Clin. Nutr. 72, 653S-669S.
• Sen C. K., Marin E., Kretzschmar M., Hanninen O., 1992. Skeletal muscle and liver glutathione homeostasis in response to training, exercise, and immobilization. J. Appl. Physiol. 73, 1265-1272.
• Seres T., Knickelbein R., Warshaw J., Johnston R. Jr., 2000. The phagocytosis associated respiratory burst in human monocytes is associated with increased uptake of glutathione.J. Immunol.165, 3333-3340.
• Skrzydlewska E., Augustyniak A., Michalak K., Farbiszewski R., 2005. Green tea supplementation in rats of different ages mitigates ethanol-induced changes in brain antioxidant abilities. Alcohol 37, 89-98.
• Smith C. V., Hansen T. N., Martin N. E., McMicken H. W., Elliott S. J., 1993. Oxidant stress responses in premature infants during exposure to hyperoxia. Pediatric Res. 34, 360-365.
• Sohal R. S., Ku H. H., Agarwal S., Forster M. J., Lal H., 1994. Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging in response to food restriction in the mouse. Mechanisms Ageing Dev. 74, 121-133.
• Somani S. M., Ryback L. P., 1996. Comparative effects of exercise training on transcription of antioxidant enzyme and the activity in old rat heart. Ind. J. Physiol. Pharmacol. 40, 205-212.
• Suter P. M., Schutz Y., Jequier E., 1992. The effect of ethanol on fat storage in healthy subjects. New Engl. J. Med., 326, 983-987.
• Tew K. D., 1994. Glutathione-associated enzymes in anticancer drug resistance. Canc. Res. 54, 4313-4320.
• Townsend D. M., Tew K. D., 2003. The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene, 22, 7369-7375.
• Turski A. T., Bald E. 2005. Mechanizm molekularny biotoksyczności homocysteiny - fakty i hipotezy. Post. Biochem. 51, 395-406.
• Van de Poll M. C., Dejong C. H., Soeters P. B., 2006. Adequate range for sulfur containing amino acids and biomarkers for their excess: lessons from enteral and parenteral nutrition. J. Nutr.136, 1694S-1700S.
• Videla L., Guerri C., 1990. Glutathione and alcohol. CRC Press, Boca Raton.
• Vogt B. L., Richie J. P. Jr., 2007. Glutathione depletion and recovery after acute ethanol administration in aging mouse. Biochem. Pharmacol. 73, 1613-1621.
• Wang R., Wang S., Ding T., Peng K., Lin X., Qiao X., Lui Y., Wu Ch., 2005. Age related changes of the redox state of glutathione in plasma. Chinese Med. J. 118, 1560-1563.
• Winiarska K., 2000. Glutation: niezwykłe funkcje pospolitego peptydu. Post. Biochem. 46, 318-326.
• Włodek L., 2003a. Cysteina, metabolizm, biologiczna rola i przyczyny toksyczności. [W:] Biotiole w warunkach fizjologicznych, patologicznych i w terapii. Włodek L. (red.). Wyd. Uniw. Jagiellońskiego, 35-63.
• Włodek L., 2003b. Glutation, antyoksydacyjne i detoksykacyjne właściwości, biologiczna i farmakologiczna regulacja biosyntezy. [W:] Biotiole w warunkach fizjologicznych, patologicznych i w terapii. Włodek L. (red.). Wyd. Uniw. Jagiellońskiego, 111-151.
• Woronowicz B. T., 2009. Uzależnienia. Geneza, terapia, powrót do zdrowia. Media Rodzina, Poznań.
• Yeh M. Y., 2007. Chronic alcoholism alters systemic and pulmonary glutathione redox status.Am. J. Resp. Crit. Care Med. 176, 270-276.
• Yeh M. Y., Burnhamc E. L., Mossc M., Brown L. A.S., 2008. Non-invasive evaluation of pulmonary glutathione in the exhaled breath condensate of otherwise healthy alcoholics. Respiratory Med. 102, 248-255.
• Yoshida A., Takemur H., Inoue H., Miyashita T., Ueda T., 2006. Inhibition of glutathione synthesis overcomes Bcl-2-mediated topoisomerase inhibitor resistance and induces nonapoptotic cell death via mitochondrial-independed pathway. Cancer Res. 66, 5772-5780.
• Zachara B. A., Szewczyk-Golec K., Tyloch J., Wolski Z., Szylberg T., Stepien S., Kwiatkowski S., Bloch-Boguslawska E., Wasowicz. W., 2005. Blood and tissue selenium concentrations and glutathione peroxidase activities in patients with prostate cancer and benign prostate hyperplasia. Neoplasma 52, 248-54.
• Zachara B. A., Gromadzińska J., Wasowicz W., Zbróg Z., 2006. Red blood cell and plasma glutathione peroxidase activities and selenium concentration in patients with chronic kidney disease: a review. Acta Biochim. Pol. 53, 663-677.
• Zachara B. A., Gromadzinska J., Zbrog Z., Swiech R., Wasowicz W., Twardowska E., Jablonska E., Sobala W., 2009. Selenium supplementation to chronic kidney disease patients on hemodialysis does not induce the synthesis of plasma glutathione peroxidase. Acta Biochim. Pol. 56, 183-187.
• Zaman G. J., Lankelma J., Van Tellingen O., Beijnen J., Dekker H., Paulusma C., Oude Elferink R. P., Baas F., Borst P., 1995. Role of glutathione in the export of compounds from cells by the multidrug-resistance-associatedd protein. Proc. Natl. Acad. Sci. USA 92, 7690-7694.
• Zima T., Fialova L., Mestek O., Janebova M., Crkovska J., Malbohan I., 2001. Oxidative stress, metabolism of ethanol and alcohol-related diseases. J. Biomed. Sci.8, 59-70.
• Ziółkowski M., Rybakowski J., 1998. Farmakoterapia uzależnienia od alkoholu. Alkoholizm Narkomania 4, 32-40.