Grelina - hormon żarłoczności?

• Authors: Artur Dembiński , Zygmunt Warzecha

Title variants

EN

Is ghrelin a hormone of gluttony?

• Languages of publication: PL EN

Abstracts

EN

The hypothalamus plays a major role in the control of energy balance and food intake. It integrates hormonal, neural and metabolic signals pertaining to body-energy status and, in response to these inputs, coordinates adaptive alterations of energy intake and expenditure. Ghrelin, a peptide produced mainly in the stomach, stimulates feeding and fat deposition. Plasma level of ghrelin is increased under negative energy balance. Ghrelin strongly and dose-dependently stimulates growth hormone release, as well as a release of prolactin and adrenocorticotropin. Moreover, pretreatment with ghrelin exhibits protective effect against damage evoked by different noxious agents. This protective effect has been found, between others, in the heart, kidney, brain, stomach, intestine and the pancreas. Apart from protective effect, administration of ghrelin exhibits also therapeutic effect in experimental heart infarct, acute pancreatitis or gastric and duodenal ulcers.

• Journal: Kosmos
• Year: 2010
• Volume: 59
• Issue: 3-4
• Pages: 297-304

Contributors

author

Artur Dembiński

• Zakład Fizjologii Klinicznej, Katedra Fizjologii, Collegium Medicum, Uniwersytet Jagielloński, Grzegórzecka 16, 31-531 Kraków, Polska

author

Zygmunt Warzecha

• Zakład Fizjologii Klinicznej, Katedra Fizjologii, Collegium Medicum, Uniwersytet Jagielloński, Grzegórzecka 16, 31-531 Kraków, Polska

References

• Akamizu T., Takaya K., Irako T. i współaut.. 2004. Pharmacokinetics, safety, and endocrine and appetite effects of ghrelin administration in young healthy subjects. Eur. J. Endocrinol. 150, 447-455.
• Ariyasu H., Takaya K., Tagami T. i współaut.. 2001. Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J. Clin. Endocrinol. Metab. 86, 4753-4758.
• Baldanzi G., Filigheddu N., Cutrupi S. i współaut., 2002. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. J. Cell Biol. 159, 1029-1037.
• Bello N. T., Coughlin J. W., Redgrave G. W., Moran T. H., Guarda A. S., 2010. Oral sensory and cephalic hormonal responses to fat and non-fat liquids in bulimia nervosa. Physiol. Behav. 99, 611-617.
• Bellone S., Castellino N., Broglio F. i współaut., 2004. Ghrelin secretion in childhood is refractory to the inhibitory effect of feeding. J. Clin. Endocrinol. Metab. 89, 1662-1665.
• Broglio F., Arvat E., Benso A. i współaut., 2001. Ghrelin, a natural GH secreatgogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans. J. Clin. Endocrinol. Metabol. 86, 5083-5083.
• Broglio F., Benso A., Castiglioni C. i współaut., 2003. The endocrine response to ghrelin as a function of gender in humans in young and elderly subjects. J. Clin. Endocrinol. Metab. 88, 1537-1542.
• Ceranowicz P., Warzecha Z., Dembinski A. i współaut., 2009. Treatment with ghrelin accelerates the healing of acetic acid-induced gastric and duodenal ulcers in rats. J. Physiol. Pharmacol. 60, 87-98.
• Cummings D. E., Shannon M. H., 2003. Roles for ghrelin in the regulation of appetite and body weight. Arch. Surg. 138, 389-396.
• Cummings D. E., Overduin J., 2007. Gastrointestinal regulation of food intake. J. Clin. Invest. 117, 13-23.
• Cunha S. R., Mayo K. E., 2002. Ghrelin and growth hormone (GH) secretagogues potentiate GH-releasing hormone (GHRH)-induced cyclic adenosine 3',5'-monophosphate production in cells expressing transfected GHRH and GH secretagogue receptors. Endocrinology 143, 4570-4582.
• Date Y., Kojima M., Hosoda H. i współaut., 2000. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 141, 4255-4261.
• Date Y., Nakazato M., Murakami N., Kojima M., Kangawa K., Matsukura S., 2001. Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochem. Biophys. Res. Commun. 280, 904-907.
• Date Y., Nakazato M., Hashiguchi S. i współaut., 2002. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes 51, 124-129.
• Dembiński A., Warzecha Z., Ceranowicz P. i współaut., 2003. Ghrelin attenuates the development of acute pancreatitis in rat. J. Physiol. Pharmacol. 54, 561-573.
• Dembiński A., Warzecha Z., Ceranowicz P. i współaut., 2005. Variable effect of ghrelin administration on pancreatic development in young rats. Role of insulin-like growth factor-1. J. Physiol. Pharmacol. 56, 555-570.
• Dembiński A., Warzecha Z., Ceranowicz P. i współaut., 2006. Role of growth hormone and insulin-like growth factor-1 in the protective effect of ghrelin in ischemia/reperfusion-induced acute pancreatitis. Growth Horm. IGF Res. 16, 348-356.
• Dembiński A., Warzecha Z., 2009. Fizjologia przewodu pokarmowego. [W:] Wykłady z fizjologii człowieka. Tafil-Klawe M., Klawe J. J. (red.). Wydawnictwo Lekarskie PZWL, Warszawa, 931-1037.
• Dezaki K., Sone H., Koizumi M. i współaut., 2006. Blockade of pancreatic islet-derived ghrelin enhances insulin secretion to prevent high-fat diet-diet induced glucose intolerance. Diabetes 55, 3486-3493.
• Dixit V. D., Schaffer E. M., Pyle R. S. i współaut., 2004. Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J. Clin. Invest. 114, 57-66.
• Dornonville De La Cour C., Lindstrom E., Norlen P., Hakanson R., 2004. Ghrelin stimulates gastric emptying but is without effect on acid secretion and gastric endocrine cells. Regul. Pept. 120, 23-32.
• Egido E. M., Rodriguez-Gallardo J., Silvestre R. A., Marco J., 2002. Inhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion. Eur. J. Endocrinol. 146, 241-244.
• Frascarelli S., GHELERDONI S., Ronca-Testoni S., Zucchi R., 2003. Effect of ghrelin and synthetic growth hormone secretagogues in normal and ischemic rat heart. Basic Res. Cardiol. 98, 401-405.
• Gnanapavan S., Kola B., Bustin S. A. i współaut., 2002. The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J. Clin. Endocrinol. Metab. 87, 2988-2991.
• Hayashida T., Nakahara K., Mondal M. S. i współaut., 2002. Ghrelin in neonatal rats: distribution in stomach and its possible role. J. Endocrinol. 173, 239-245.
• Howard A. D., Feighner S. D., Cully D. F. i współaut., 1996. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273, 974-977.
• Huang C. X., Yuan M. J., Huang H. i współaut., 2009. Ghrelin inhibits post-infarct myocardial remodeling and improves cardiac function through anti-inflammation effect. Peptides 30, 2286-2291.
• Inui A., Asakawa A., Bowers C. Y., Mantovani G., Laviano A., Meguid M. M., Fujimiya M., 2004. Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ. FASEB J. 18, 439-456.
• Kojima M., Hosoda H., Date Y., Nakazato M., Matsuo H., Kangawa K., 1999. Ghrelin is a growth-hormone releasing acylated peptide from stomach. Nature 402, 656-660.
• Kojima S., Nakahara T., Nagai N. i współaut., 2005. Altered ghrelin and peptide YY responses to meals in bulimia nervosa. Clinical Endocrinol. (Oxf.) 62, 74-78.
• Lear P. V., Iglesias M. J., Feijóo-Bandín S. i współaut. 2010. Des-acyl ghrelin has specific binding sites and different metabolic effects from ghrelin in cardiomyocytes. Endocrinology 151, 3286-3298.
• Lee H. M., Wang G., Englander E. W., Kojima M., Greeley G. H. Jr. i współaut., 2002. Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinology 143, 185-190.
• Liu Y., Wang P.S., Xie D., Liu K., Chen L., 2006. Ghrelin reduces injury of hippocampal neurons in a rat model of cerebral ischemia/reperfusion. Chin. J. Physiol. 49, 244-250.
• Masuda Y., Tanaka T., Inomata N. i współaut., 2000. Ghrelin stimulates gastric acid secretion and motility in rats. Biochem. Biophys. Res. Commun. 276, 905-908.
• Peeters T. L., 2005. Ghrelin: a new player in the control of gastrointestinal functions. Gut 54, 1638-1649.
• Pong S. S., Chaung L. Y. P., Dean D., Nargund R. P., Patchett A. A., Smith R. G., 1996. Identification of new G-protein-linked receptor for growth hormone secretagogues. Mol. Endocrinol. 10, 57-61.
• Reimer M. K., Pacini G., Ahren B., 2003. Dose-dependent inhibition by ghrelin of insulin secretion in the mouse. Endocrinology 144, 916-921.
• Rodríguez A., Gómez-Ambrosi J., Catalán V. i współaut. 2009. Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes. Int. J. Obes. (London) 33, 541-552.
• Saito E. S., Kaiya H., Takagi T. i współaut., 2002. Chicken ghrelin and growth hormone-releasing peptide-2 inhibit food intake of neonatal chicks. Eur. J. Pharmacol. 453, 75-79.
• Shiiya T., Nakazato M., Mizuta M. i współaut., 2002. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J. Clin. Endocrinol. Metab. 87, 240-244.
• Sibilia V., Rindi G., Pagani F. i współaut., 2003. Ghrelin protects against ethanol-induced gastric ulcers in rats: studies on the mechanisms of action. Endocrinology 144, 353-359.
• Suzuki K., Simpson K. A., Minnion J. S., Shillito J. C., Bloom S. R., 2010. The role of gut hormones and the hypothalamus in appetite regulation. Endocr. J. 57, 359-372.
• Takeda R., Nishimatsu H., Suzuki E. i współaut., 2006. Ghrelin improves renal function in mice with ischemic acute renal failure. J. Am. Soc. Nephrol. 17, 113-121.
• Toshinai K., Date Y., Murakami N. i współaut. 2003. Ghrelin-induced food intake is mediated via the orexin pathway. Endocrinology 144, 1506-1512.
• Tschöp M., Weyer C., Tataranni P. A., Devanarayan V., Ravussin E., Heiman M. L., 2001. Circulating ghrelin levels are decreased in human obesity. Diabetes 50, 707-709.
• Van Der Lely A. J., Tschöp M., Heiman M. L., Ghio E., 2004. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocrine Rev. 25, 426-457.
• Warzecha Z., Ceranowicz P., Dembiński A. i współaut., 2010. Therapeutic effect of ghrelin in the course of cerulein-induced acute pancreatitis in rats. J. Physiol. Pharmacol. 61, 419-427.
• Wierup N., Svensson H., Mulder H., Sundler F., 2002. The ghrelin cell: a novel developmentally regulated islet cell in the human pancreas. Regul. Pept. 107, 63-69.
• Wren A. M., Small C. J., Ward H. L., i współaut. 2000. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141, 4325-4328.
• Wren A. M., Seal L. J., Cohen M. A. i współaut., 2001a. Ghrelin enhances appetite and increases food intake in humans. J. Clin. Endocrinol. Metab. 86, 5992-5995.
• Wren A. M., Small C. J., Abbott C. R. i współaut., 2001b. Ghrelin causes hyperphagia and obesity in rats. Diabetes 50, 2540-2547.
• WU R., Dong W., Zhou M. i współaut., 2007. Ghrelin attenuates sepsis-induced acute lung injury and mortality in rats. Am. J. Respir. Crit. Care Med. 176, 805-813.
• Yang J., Brown M. S., Liang G., Grishin N. V., Goldstein J. L., 2008. Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132, 387-396.
• Zhang W., Chen M., Chen X., Segura B. J., Mulholland M. W., 2001. Inhibition of pancreatic protein secretion by ghrelin in the rat. J. Physiol. 537, 231-236.
• Zhang J. V., Ren P. G., Avsian-Kretchmer O. i współaut., 2005. Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Science 310, 996-999.