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2010 | 59 | 1-2 | 133-139
Article title

Kapsaicyna - lek czy trucizna?

Content
Title variants
EN
Capsaicin - cure or poison?
Languages of publication
PL EN
Abstracts
EN
Capsaicin, an organic compound produced by plants from the Capsicum family, is responsible for the spicy taste of pepper. It is widely applied in the medicine and as the food additive. The biological activities and pharmacological actions have been widely studied for the latest years. Capsaicin acts on vanilloid receptors located in dorsal root and trigeminal ganglia, which is perceived as pain and heat. This substance exerts an influence on thermoregulation in organism, causing activation of both heat dissipation and production processes. Capsaicin is widely used as analgesic, and its chemopreventive and anticarcinogenic activity is now extensively studied. On the other hand, capsaicin is also used as a repellent against mammals and insects. This review summarizes recent information about molecular targets and the usage of capsaicin.
Keywords
Journal
Year
Volume
59
Issue
1-2
Pages
133-139
Physical description
Dates
published
2010
Contributors
  • Zakład Toksykologii Zwierząt, Instytut Biologii Ogólnej i Molekularnej, Uniwersytet Mikołaja Kopernika, Gagarina 9, 87-100 Toruń, Polska
References
  • Caterina M. J., 2007. Transient receptor potential ion channels as participants in thermosensation and thermoregulation. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 292, 64-76.
  • Caterina M. J., Schumacher M. A., Tominaga M., Rosen T. A., Levine J. D., Julius D., 1997. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816-824.
  • Chanda S., Mould A., Esmail A., Bley K., 2005. Toxicity studies with pure trans-capsaicin delivered to dogs via intravenous administration. Regul. Toxicol. Pharmacol. 43, 66-75.
  • Chard P. S., Bleakman D., Savidge J. R., Miller R. J., 1995. Capsaicin - induced neurotoxicity in cultured dorsal root ganglion neurons: involvement of calcium - activated proteases. Neuroscience 65, 1099-1108.
  • Clapham D. E., 1997. Some like it hot: spicing up ion channels. Nature 389, 783-784.
  • Cromer B. A., McIntyre P., 2008. Painful toxins acting at TRPV1. Toxicon. 51, 163-173.
  • D'Andrea A. D., Haseltine W. A., 1978. Modification of DNA by aflatoxin B1 creates alkali-labile lesions in DNA At positions of guanine and adenine. Proc. Natl. Acad. Sci. USA 75, 4120-4124.
  • Fitzgerald C. S., Curtis P. D., Richmond M. E., Dunn J. A., 1995. Effectiveness of capsaicin as a repellent to birdseed consumption by gray squirrels. [W:] Repellents in Wildlife Management: Proceedings of a Symposium. Mason J. R. (red.). National Wildlife Research Center, Fort Collins, Colo, 169-83.
  • Hayman M., Kam P. C. A., 2008. Capsaicin: A review of its pharmacology and clinical applications. Curr. Anaesth. Crit. Care 19, 338-343.
  • Hogan P. G., Li H., 2005. Calcineurin. Curr. Biol. 15, 442-443.
  • Jancsó-Gábor A., Szolcsányi J., Jancsó N., 1970. Irreversible impairment of thermoregulation induced by capsaicin and similar pungent substances in rats and guinea-pigs. J. Physiol. 206, 495-507.
  • Kobayashi A., Osaka T., Namba Y., Inoue S., Lee T. H., Kimura S., 1998. Capsaicin activates heat loss and heat production simultaneously and independently in rats. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 275, 92-98.
  • Kozłowski J., Kałuski T., Jaskulska M., 2008. Badania laboratoryjne nad ograniczeniem uszkodzeń roślin rzepaku przez ślinika luzytańskiego (Arion lusitanicus Mabille). Postępy w Ochronie Roślin 48, 889-892.
  • Macpherson L. J., Geierstanger B. H., Viswanath V., Bandell M., Eid S. R., Hwang S., Patapoutian A., 2005. The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr. Biol. 15, 929-934.
  • Madhumathy A. P., Aivazi A.-A., Vijayan V. A., 2007. Larvicidal efficacy of Capsicum annum against Anopheles stephensi and Culex quinquefasciatus. J. Vect. Borne Dis. 44, 223-226.
  • Mason L., Moore A., Derry S., Edwards J. E., Mcquay H. J., 2004. Systematic review of topical capsaicin for the treatment of chronic pain. BMJ, doi:10.1136/bmj.38042.506748.EE
  • McNamara F. N., Randall A., Gunthorpe M. J., 2005. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br. J. Pharmacol. 144, 781-790.
  • Miller C. H., Zhang Z., Hamilton S. M., Teel R. W., 1993. Effects of capsaicin on liver microsomal metabolism of the tobacco-specific nitrosoamine NNK. Cancer Lett. 75, 45-52.
  • Mohapatra D. P, Nau C., 2003. Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway. J. Biol. Chem. 278, 50080-50090.
  • Mori A., Sören L., O'kelly J., Kumagai T., Desmond J. C., Pervan M., Mcbride W. H., Kizaki M, Koeffler H. P., 2006. Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells. Cancer Res. 66, 3222-3229.
  • Numazaki M., Tominaga T., Takeuchi K., Muryama N., Toyooka H., Tominaga M., 2003. Structural determinant of TRPV1 desensitization interacts with calmodulin. Proc. Natl. Acad. Sci. USA 100, 8002-8006.
  • O'Neil R. G., Brown R. C., 2003. The vanilloid receptor family of calcium-permeable channels: molecular integrators of microenvironmental stimuli. News Physiol. Sci. 18, 226-231.
  • Olszewska J., Adamkiewicz B., Grajpel B., Tęgowska E., 2009. Kapsaicyna zwiększa toksyczność insektycydów karbaminianowych w stosunku do larw mącznika młynarka Tenebrio monitor. Mechanizmy służące utrzymaniu życia i regulacji fizjologicznych, XXIII Ogólnopolskie Seminarium pod redakcją Henryka Lacha, Kraków 2009, 97-99.
  • Potargowicz E., Szerszenowicz E., Staniszewska M., Nowak M., 2005. Mitochondria jako źródło reaktywnych form tlenu. Postępy Hig. Med. Dośw. 59, 259-266.
  • Remadevi R., Szallasi A., 2008. Adlea (ALGRX-4975) an injectable capsaicin (TRPV1 receptor agonist) formulation for long-lasting pain relief. IDrugs 11, 120-132.
  • Rogers L. L., 1984. Reactions of free-ranging black bears to capsaicin spray repelent. Wildl. Soc. Bull 12, 59-61.
  • Simone D. A., Nolano M., Johnson T., Wendelschafer-Crabb G., Kennedy W., 1998. Intradermal injection of capsaicin in humans produces degeneration and subsequent reinnervation of epidermal nerve fibers: correlation with sensory function. J. Neurosci. 18, 8947-8959.
  • Spurr E. B., McGregor P. G., 2003. Potential invertebrate antifeedants for toxic baits used for vertebrate pest control, Science for Conservation 232.
  • Sugimoto T., Xiao C., Ichikawa H., 1998. Neonatal primary neuronal death induced by capsaicin and axotomy involves an apoptotic mechanism. Brain Research 807, 147-154.
  • Surh Y.-J., 2002. More than spice: capsaicin in hot chili pepper makes tumor cells commit suicide. J. Natl. Cancer Inst. 94, 1263-1265.
  • Surh Y.-J., Lee S. S., 1995. Capsaicin, a double edge sword: toxicity, metabolism and chemopreventive potential. Life Sciences 56, 1845-1855.
  • Surh Y.-J., Lee S. S., 1996. Capsaicin in hot chili pepper: carcinogen, co-carcinogen or anticarcinogen? Fd. Chem. Toxic. 34, 313-316.
  • Szallasi A., 2002. Vanilloid (capsaicin) receptors in health and disease. Am. J. Clin. Pathol. 118, 110-121.
  • Szallasi A., Blumberg P. M., 1999. Vanilloid (capsaicin) receptors and mechanisms. Pharmacol. Rev. 51, 160-211.
  • Szallasi A., Cruz F., Geppetti P., 2006. TRPV1: a therapeutic target for novel analgesic drugs? Trends Mol. Med. 12, 545-554.
  • Szöke É., Seress L., Szolcsányi J., 2002. Neonatal capsaicin treatment results in prolonged mitichondria damage and delayed cell death of B cells in the rat trigeminal ganglia. Neuroscience 113, 925-937.
  • Szumiło J., 2009. Środki pochodzenia naturalnego w chemoprewencji raka płaskonabłonkowego przełyku - badania doświadczalne. Pol. Merk. Lek. 26, 156-161.
  • Teel R. W., 1991. Effect of capsaicin on rat liver S9-mediated metabolism and DNA binding of aflatoxin. Nutr. Cancer 15, 27-32.
  • Tęgowska E., 2003. Insecticides and thermoregulation in insects. Pestycydy 1-4, 47-75.
  • Tominaga M., Julius D., 2000. Capsaicin receptor in the pain pathway. Jpn. J. Pharmacol. 83, 20-24.
  • Trevisani M., Smart D., Gunthorpe M. J., Tognetto M., Barbieri M., Campi B., Amadesi S., Gray J., Jerman J. C., Brough S. J., Owen D., Smith G. D., Randall A. D., Harrison S., Bianchi A., Davis J. B., Gepetti P., 2002. Ethanol elicits and potentiates nociceptor responses via the vanilliod receptor-1. Nat. Neurosci. 5, 546-551.
  • Wagner K. K, Nolte D. L., 2000. Evaluation of Hot Sauce as a repellent for forest mammals. Wildl. Soc. Bull 28, 76-83.
  • Winter J., Bevan S., Campbell E. A., 1995. Capsaicin and pain mechanisms. Br. J. Anaesth. 75, 157-168.
  • Xu H., Blair N. T., Clapham D. E., 2005. Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. J. Neurosci. 25, 8924-8937.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-ksv59p133kz
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