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Number of results

Journal

2009 | 58 | 3-4 | 555-558

Article title

Ludzki genom mitochondrialny

Authors

Content

Title variants

EN
The human mitochondrial genome

Languages of publication

PL EN

Abstracts

EN
The human mitochondrial genome is a small 16.5 kb circular double-stranded DNA molecule containing 37 genes. Mutations in this DNA can lead to various diseases, and the mitochondrial DNA (mtDNA) genome which is maternally inherited has been very often used in studies on human evolution. Mitochondria of all humans appear to originate from one woman who lived in Africa about 180000 years ago. Various parts of the mtDNA may not evolve at the same rate, and the different mitochondrial DNA haplogroups may not be totally functionally equivalent, raising questions as to the involvement of mitochondria in various human diseases and the process of aging.

Keywords

Journal

Year

Volume

58

Issue

3-4

Pages

555-558

Physical description

Dates

published
2009

Contributors

author
  • Instytut Genetyki i Biotechnologii, Wydział Biologii Uniwersytetu Warszawskiego, oraz Instytut Biochemii i Biofizyki PAN, Pawińskiego 5a, 02-106 Warszawa, Polska

References

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  • Cann R. L., Stoneking M., Wilson A. C., 1987. Mitochondrial DNA and human evolution. Nature 325: 31-36.
  • Howell, N., Elson J. E., Howell C., Turnbull D. M. 2007. Relative rates of evolution in the coding and control regions of African mtDNAs. Mol. Biol. Evol. 24, 2213-2221.
  • Ingman, M., Gyllensten U., 2006. mtDB: Human Mitochondrial Genome Database, a resource for population genetics and medical sciences. Nucleic Acids Res. 34 (Database issue): D749-51.
  • Mishmar D., Ruiz-pesini E. F., Golik P., Macaulay V., Clark A. G. i współaut., 2003. Natural selection shaped regional mtDNA variation in humans. Proc. Natl. Acad. Sci. USA 100, 171-176.
  • Moilanen J. S., Finnila S., Majamaa K. 2003. Lineage-specific delection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J. Mol. Biol. Evol. 20, 2132-2142.
  • Parmley J. L., Hurst L. D., 2007. How do synonymous mutaitons affect fitness? BioEssays 29, 515-519.
  • Sun C., Kong Q.p., Zhang Y. P., 2007. The role of climate in human mitochondrial DNA evolution: a reappraisal. Genomics 89, 338-342.
  • Tońska K., Sołyga A., Bartnik E. 2009. Mitochondria and aging: innocent bystanders or guilty parties? J. Appl. Genet. 50, 55-62.
  • Wallace D. C., 1995. Mitochondrial DNA in human evolution, degenerative disease, and aging. Am. J. Hum. Genet. 57, 201-203.
  • Wallace D. C., 2005. A mitochondrial paradigm of metabolic and degenerative diseases, aging and cancer: a dawn for evolutionary medicine. Annu. Rev Genet 39, 359-407.

Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.bwnjournal-article-ksv58p555kz
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