Telomery - duża rola małych sekwencji

• Authors: Urszula Gągała , Katarzyna Andraszek , Ewa Wójcik , Elżbieta Smalec

Title variants

EN

Telomeres - a significant role of small sequences

• Languages of publication: PL EN

Abstracts

EN

Telomeres are distal structures of eukaryotic chromosomes, which are responsible for their stability and functioning. They assure complete replication of terminal fragments of chromosomes, prevent degradation and fusion of chromosomes. Telomeres of most chordates are comprised of tandem repeats of the basic unit 5'-(TTAGGG)n-3'. The number of repeats of the basic telomeric sequence differs between the chromosomes of one and the same cell. However, in remains within the strictly determined range for a given species, for man it ranges from 2 to 30 th pairs of nucleotides. Younger cells have got longer telomeres whereas the telomeres of older cells are shorter. Cytogenetic studies on telomeric regions of chromosomes have gained significance since the moment of the discovery that this chromosomal fragment actively participates in the process of cancer development, cell ageing and apoptosis. Telomeres consist of non-coding DNA sequences. They contain no genes and they code no proteins but their role in medicine, genetics and evolutionary studies is becoming more and more significant.

• Journal: Kosmos
• Year: 2008
• Volume: 57
• Issue: 3-4
• Pages: 331-341

Dates

published

2008

Contributors

author

Urszula Gągała

• Instytut Bioinżynierii i Hodowli Zwierząt, Akademia Podlaska, B. Prusa 14, 08-110 Siedlce, Polska

author

Katarzyna Andraszek

• Instytut Bioinżynierii i Hodowli Zwierząt, Akademia Podlaska, B. Prusa 14, 08-110 Siedlce, Polska

author

Ewa Wójcik

• Instytut Bioinżynierii i Hodowli Zwierząt, Akademia Podlaska, B. Prusa 14, 08-110 Siedlce, Polska

author

Elżbieta Smalec

• Instytut Bioinżynierii i Hodowli Zwierząt, Akademia Podlaska, B. Prusa 14, 08-110 Siedlce, Polska

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