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Journal
2007 | 56 | 1-2 | 87-97
Article title

Metabolizm i toksyczność kadmu u człowieka i zwierząt

Content
Title variants
EN
Metabolism and toxicity of cadmium in humans and animals
Languages of publication
PL EN
Abstracts
EN
Cadmium (Cd(II)) is one of the most important toxic chemicals due to its increasing level in the environment as a result of industrial and agricultural practices. Cd(II) has a very long biological half-life (10-30 years) in humans and its toxicity is dependent on the dose, route and duration of exposure. Cd(II) is absorbed from the gastro-intestinal tract primarily by utilizing transporters for essential elements such as iron and zinc, as well as calcium channels. In this review multiple mechanisms of Cd(II) toxicity are discussed, such as interference with enzymes of the cellular antioxidant system and generation of reactive oxygen species, modulation of signal transduction and gene expression, inhibition of DNA repair and DNA methylation, and disruption of E-cadherin-mediated cell-cell adhesion. The role of Cd(II) in apoptosis is also discussed.
Keywords
Journal
Year
Volume
56
Issue
1-2
Pages
87-97
Physical description
Dates
published
2007
Contributors
  • Instytut Biologii, Uniwersytet w Białymstoku, Świerkowa 20B, 15-950 Białystok, Polska
  • Instytut Biologii, Uniwersytet w Białymstoku, Świerkowa 20B, 15-950 Białystok, Polska
  • Instytut Biologii, Uniwersytet w Białymstoku, Świerkowa 20B, 15-950 Białystok, Polska
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Document Type
Publication order reference
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YADDA identifier
bwmeta1.element.bwnjournal-article-ksv56p87kz
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