Preferences help
enabled [disable] Abstract
Number of results
2007 | 56 | 1-2 | 63-74
Article title

Zmiany plastyczne w zdrowym i chorym mózgu

Title variants
Plastic changes in healthy and damaged brain
Languages of publication
During the last several years there has been an increased interest in the ability of the adult central nervous system to reorganize itself in response to injury and to environmental input. Although evidence for plastic changes in animals is considerable, until quite recently there have been few attempts to look for brain reorganization in human subjects and to demonstrate the behavioral consequences of those effects. Here is presented a review of the experiments showing that in humans the brain is also capable of substantial reorganization throughout life in response to environmental changes. One of the findings is that cortex deprived of sensory input in one modality can be recruited by other modalities to process information in a functionally relevant manner. Because behaviorally manipulated use-dependent plasticity could be of value in solving clinical problems, new therapies for patients with various deficits have recently been developed on the base of the research data.
Physical description
  • Pracownia Psychofizjologii, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Pasteura 3, 02-093 Warszawa, Polska
  • Amedi A., Raz N., Pianka P., Malach R., Zohary E., 2003. Early 'visual' cortex activation correlates with superior verbal memory performance in the blind. Nat. Neurosci. 6, 758-766.
  • Amedi A., Floel A., Knecht S., Zohary E., Cohen L. G., 2004. Transcranial magnetic stimulation of the occipital pole interferes with verbal processing in blind subjects. Nat. Neurosci. 7, 1266-1270.
  • Bavelier D., Dye M. W., Hauser P.C., 2006. Do deaf individuals see better? Trends Cogn. Sci. 10, 512-518.
  • Boroojerdi B., Battaglia F., Muellbacher W., Cohen L. G., 2001. Mechanisms influencing stimulus-response properties of the human corticospinal system. Clin. Neurophysiol. 112, 931-937.
  • Borsook D., Becerra L., Fishman S., Edwards A., Jennings C. L., Stojanovic M., Papinicolas L., Ramachandran V. S., Gonzalez R. G., Breiter H., 1998. Acute plasticity in the human somatosensory cortex following amputation. Neuroreport 9, 1013-1017.
  • Brasil-Neto J. P., Cohen L. G., Pascual-Leone A., Jabir F. K., Wall R. T., Hallett M., 1992. Rapid reversible modulation of human motor outputs after transient deafferentation of the forearm: a study with transcranial magnetic stimulation. Neurology 42, 1302-1306.
  • Cohen L. G., Celnik P., Pascual-Leone A., Corwell B., Falz L., Dambrosia J., Honda M., Sadato N., Gerloff C., Catala M. D., Hallett M., 1997. Functional relevance of cross-modal plasticity in blind humans. Nature 389, 180-183.
  • Cohen L. G., Weeks R. A., Sadato N., Celnik P., Ishii K., Hallett M., 1999. Period of susceptibility for cross-modal plasticity in the blind. Ann. Neurol. 45, 451-460.
  • Cybulska-Klosowicz A., Kossut M., 2006. Oddziaływania międzypółkulowe w procesach neuroplastycznych. Neuropsychiatria i Neuropsychologia 1, 15-23.
  • Elbert T., Pantev C., Wienbruch C., Rockstroh B., Taub E., 1995. Increased cortical representation of the fingers of the left hand in string players. Science 270, 305-307.
  • Elbert T., Sterr A., Rockstroh B., Pantev C., Muller M. M., Taub E., 2002. Expansion of the tonotopic area in the auditory cortex of the blind. J. Neurosci. 22, 9941-9944.
  • Godde B., Ehrhardt J., Braun C., 2003. Behavioral significance of input-dependent plasticity of human somatosensory cortex. Neuroreport 14, 543-546.
  • Goldreich D., Kanics I. M., 2003. Tactile acuity is enhanced in blindness. J. Neurosci. 23, 3439-3445.
  • Kaas J. H.,1991. Plasticity of sensory and motor maps in adult mammals. Annu. Rev. Neurosci. 14, 137-167.
  • Kaas J. H., Merzenich M. M., Killackey H. P., 1983. The reorganization of somatosensory cortex following peripheral nerve damage in adult and developing mammals. Annu. Rev. Neurosci. 6, 325-356.
  • Kew J. J., Ridding M. C., Rothwell J. C., Passingham R. E., Leigh P. N., Sooriakumaran S., Frackowiak R. S., Brooks D. J., 1994. Reorganization of cortical blood flow and transcranial magnetic stimulation maps in human subjects after upper limb amputation. J. Neurophysiol. 72, 2517-2524.
  • Korte M., Rauschecker J.P., 1993. Auditory spatial tuning of cortical neurons is sharpened in cats with early blindness. J. Neurophysiol. 70, 1717-1721.
  • Kujala T., Alho K., Naatanen R., 2000. Cross-modal reorganization of human cortical functions. Trends Neurosci. 23, 115-120.
  • Lessard N., Pare M., Lepore F., Lassonde M., 1998. Early-blind human subjects localize sound sources better than sighted subjects. Nature 395, 278-280.
  • Liepert J., Tegenthoff M., Malin J. P., 1995. Changes of cortical motor area size during immobilization. Electroencephalogr. Clin. Neurophysiol. 97, 382-386.
  • Liotti M., Ryder K., Woldorff M. G., 1998. Auditory attention in the congenitally blind: where, when and what gets reorganized? Neuroreport 9, 1007-1012.
  • Pascual-Leone A., 1996. Reorganization of cortical motor outputs in the aquisition of new motor skills. [W:] Recent Advances in Clinical Neurophysiology. Kinura J., Shibasaki H. (red.). Amsterdam: Elsevier, 304-308. .
  • Pascual-Leone A., Torres F., 1993. Plasticity of the sensorimotor cortex representation of the reading finger in Braille readers. Brain 116, 39-52.
  • Pascual-Leone A., Hamilton R., 2001. The metamodal organization of the brain. Prog. Brain Res. 134, 427-445.
  • Pascual-Leone A., Nguyet D., Cohen L. G., Brasil-Neto J. P., Cammarota A., Hallett M., 1995. Modulation of muscle responses evoked by transcranial magnetic stimulation during the acquisition of new fine motor skills. J. Neurophysiol. 74, 1037-1045.
  • Pascual-Leone A., Amedi A., Fregni F., Merabet L. B., 2005. The plastic human brain cortex. Annu Rev. Neurosci. 28, 377-401.
  • Perkel D. J., LeVay S., 1984. Effects of strabismus and monocular deprivation on the eye preference of neurons in the visual claustrum of the cat. J. Comp. Neurol. 230, 269-277.
  • Ramachandran V. S., Blakeslee S., 1998. Phantoms in the brain. New York: HarperCollins Publishers Inc.
  • Rauschecker J. P., Korte M., 1993. Auditory compensation for early blindness in cat cerebral cortex. J. Neurosci. 13, 4538-4548.
  • Rauschecker J. P., Tian B., Korte M., Egert U., 1992. Crossmodal changes in the somatosensory vibrissa/barrel system of visually deprived animals. Proc. Natl. Acad. Sci. USA 89, 5063-5067.
  • Rettenbach R., Diller G., Sireteanu R., 1999. Do deaf people see better? Texture segmentation and visual search compensate in adult but not in juvenile subjects. J. Cogn. Neurosci. 11, 560-583.
  • Roder B., Teder-Salejarvi W., Sterr A., Rosler F., Hillyard S. A., Neville H. J., 1999. Improved auditory spatial tuning in blind humans. Nature 400, 162-166.
  • Roder B., Stock O., Bien S., Neville H., Rosler F., 2002. Speech processing activates visual cortex in congenitally blind humans. Eur. J. Neurosci. 16, 930-936.
  • Sterr A., Muller M.M., Elbert T., Rockstroh B., Pantev C., Taub E., 1998. Perceptual correlates of changes in cortical representation of fingers in blind multifinger Braille readers. J. Neurosci. 18, 4417-4423.
  • Tyc F., Boyadjian A., Devanne H., 2005. Motor cortex plasticity induced by extensive training revealed by transcranial magnetic stimulation in human. Eur. J. Neurosci. 21, 259-266.
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.