Preferences help
enabled [disable] Abstract
Number of results
2007 | 56 | 3-4 | 343-347
Article title

Tajemnice udaru mózgu: rola wapnia i magnezu w śmierci neuronów strefy półcienia

Title variants
The mistery of stroke: the role of calcium and magnesium in the penumbra neurons' death
Languages of publication
Penumbra zone is localized on the border of ischaemic focus. Low cerebral blood flow allows the neurons to survive but it is insufficient for normal processes. Calcium ions play a significant role in the development of apoptosis within the neurons in penumbra. Intracellular calcium "swiches on" releasing cytochrom c from mitochondria - which is an important component of apoptosis. Extracellular calcium binds to the specific receptor localized on the cell membrane and activates antiapoptotic pathway which helps the cell to survive. Magnesium, in contrast to calcium ions, also excerts an antiapoptotic effect in the intracellular localization. Inhibition of glutamate (aminoacid which takes part in excitotoxicy) had brought the hope that magnesium could have been used in the stroke treatment. Unfortunately huge clinical trial with magnesium early administration in the acute ischemic stroke did not show the significant benefits of magnesium treatment. Future studies should be focused on recognition of molecular mechanism of magnesium and calcium ions acting in the excitotoxicy and apoptosis of the penumbra neurons.
Physical description
  • Katedra i Zakład Biochemii i Biologii Molekularnej, Akademia Medyczna w Lublinie, Chodźki 1, 20-093 Lublin, Polska
  • Bouschet T., Henley J. M., 2005. Calcium as an extracellular signaling molecule: perspectives on the Calcium Sensing Receptor in the brain. C. R. Biol. 328, 691-700.
  • Castillo J., Rodriguez I., 2004. Biochemical changes and inflammatory response as markers for brain ischaemia: molecular markers of diagnostic utility and prognosis in human clinical practice. Cerebrovasc. Dis. 17(Suppl 1), 7-18.
  • Hallak M., Berman R. F., Irtenkauf S. M., Janusz C. A., Cotton D. B., 1994. Magnesium sulfate treatment decreases N-methyl-D-aspartate receptor binding in the rat brain: An autoradiographic study. J. Soc. Gynecol. Invest.1, 25-30.
  • Marzo I., Brenner C., Zamzami N., Susin S. A., Beutner G., Brdiczka D., Remy R., Xie Z., Reed J. C., KroemeR G., 1998. The permeability transition pore complex: a target for apoptosis regulation by Caspases and Bcl-2-related Proteins. J. Exp. Med. 187, 1261-1271.
  • Matson M. P., Chan S. L., 2003. Calcium orchestrates apoptosis. Nat. Cell. Biol. 5, 1041-1043.
  • Muir K. W., 2000. Therapeutic potential of Magnesium in the Treatment of Acute Stroke. J. Stroke Cerebrovasc. Dis. 9, 257-267.
  • Muir K. W., Lees K. R., Ford I., Davis S. i współaut., 2004. Magnesium for acute stroke (Intravenous magnesium efficacy in stroke trial): randomized control trial. Lancet 363, 439-445.
  • Ovbiagele B., Liebeskind D. S., Starkman S., Sanossian N., Kim D., Razina T., Saver J. L., 2006. Are elevated admission calcium levels associated with better outcomes after ischemic stroke ? Neurology 67, 170-173.
  • Rożynkowa D., Filip A., 1999. Endogenne białka przeciwdziałające apoptozie. Postępy Biol. Kom. 26, 561-578.
  • Rupniewska Z., Bojarska-junak A., 2004. Apoptoza: Przepuszczalność błony mitochondrialnej i rola pełniona przez białka z rodziny Bcl-2. Postępy Hig. Med. Dośw. 58, 538-547.
  • Stepulak A., Sifringer M., Rzeski W., Endesfelder S., Gratopp A.,, Elena E. Pohl E. E., Bittigau P., Felderhoff-mueser U., Kaindl A. M., Buhrer C., Hansen H. H., Stryjecka-zimmer M., Turski L., Ikonomidou C., 2005. NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growth. Proc. Nat. Acad. Sci. USA 102, 15605-15610.
  • Warlow C., Sudlow C., Dennis M., Wardlaw J., Sandercock P., 2003. Stroke. Lancet 362, 1211-1224.
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.