Preferences help
enabled [disable] Abstract
Number of results
2007 | 56 | 1-2 | 27-38
Article title

Zapalenie (ostre) jako reakcja korzystna dla organizmu - historia badań a najnowsze osiągnięcia

Title variants
Acute inflammation as a beneficial process - history and recent developments
Languages of publication
The first description of inflammation as "rubor et tumor cum calore et dolore" dated for the 1st century could not be more precise: redness and edema accompanied by heat and pain. Since the times of Celsus, the author of the above words, many followers aimed at investigating the phenomenon of inflammation. Their work and findings are presented and discussed, including the studies of Galen, John Hunter, Rudolf Virchow, Julius Conheim, Elie Metchnikoff, Paul Ehrlich, Ludwig Aschoff, Thomas Lewis, and Maurício Rocha e Silva. Their discoveries and theories to allowed to define inflammation as a response of the body to infection or injury aimed at elimination of the invader and healing of the injured tissue(s). The characteristic stages of acute inflammation are described here in detail. Now it is definitely known that acute inflammation is beneficial to the body as it allows elimination of pathogens and healing, and thus prevents development of chronic inflammation that is a pathological disorder that might lead to development of cancer. Even the biggest disadvantage of inflammation - pain - seems to perform an important function of alerting to some abnormality. In summary, acute inflammation terminated after successful elimination of the pathogen is a valuable reaction keeping the homeostasis of an organism.
Physical description
  • Ajuebor M. N., Flower R. J., Hannon R., Christie M., Bowers K., Verity A., Perretti M., 1998. Endogenous monocyte chemoattractant protein-1 recruits monocytes in the zymosan peritonitis model. J. Leukoc. Biol. 63, 108-116.
  • Ajuebor M. N., Das A. M., Virag L., Szabo C., Perretti M., 1999. Regulation of macrophage inflammatory protein-1 alpha expression and function by endogenous interleukin-10 in a model of acute inflammation. Biochem. Biophys. Res. Commun. 255, 279-282.
  • Anversa P., Kajstura J., Leri A., 2004. Circulating progenitor cells: Search for an identity. Circulation 110, 3158-3160.
  • Aschoff L., 1924. Lectures on pathology. New York, Paul B. Hoeber, Inc.
  • Belvisi M. G., 2003. Sensory nerves and airway inflammation: Role of a delta and c-fibres. Pulm. Pharmacol. Ther. 16, 1-7.
  • Broad A., Jones D. E., Kirby J. A., 2006. Toll-like receptor (tlr) response tolerance: A key physiological 'Damage limitation' Effect and an important potential opportunity for therapy. Curr. Med. Chem. 13, 2487-2502.
  • Brogden K. A., Ackermann M., McCray P. B., Jr., Tack B. F., 2003. Antimicrobial peptides in animals and their role in host defences. Int. J. Antimicrob. Agents. 22, 465-478.
  • Buckley C. D., 2003. Michael mason prize essay 2003. Why do leucocytes accumulate within chronically inflamed joints? Rheumatology (Oxford) 42, 1433-1444.
  • Charo I. F., Ransohoff R. M., 2006. The many roles of chemokines and chemokine receptors in inflammation. N. Engl. J. Med. 354, 610-621.
  • Chodorowska G., Rogus-Skorupska D., 2004. Cutaneous wound healing. Ann. Univ. Mariae Curie Sklodowska (Med) 59, 403-407.
  • Cohnheim J., 1867. Ueber entzündung und eiterung Virchows Arch. Pathol. Ana. Physiol. Klin. Med. 40, 1-79.
  • Eming S. A., Krieg T., Davidson J. M., 2007. Inflammation in wound repair: Molecular and cellular mechanisms. J. Invest. Dermatol. 127, 514-525.
  • Farrow B., Sugiyama Y., Chen A., Uffort E., Nealon W., Mark Evers B., 2004. Inflammatory mechanisms contributing to pancreatic cancer development. Ann. Surg. 239, 763-679; discussion 769-771.
  • Fernandez-Botran R., 2000. Soluble cytokine receptors: Novel immunotherapeutic agents. Expert Opin. Investig. Drugs 9, 497-514.
  • Fialkow L., Wang Y., Downey G. P., 2007. Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic. Biol. Med. 42, 153-164.
  • Golab J., Jakobisiak M., Lasek W., 2002. Immunologia. Warszawa, Wydawnictwo Naukowe PWN.
  • Han J., Ulevitch R. J., 2005. Limiting inflammatory responses during activation of innate immunity. Nat. Immunol. 6, 1198-1205.
  • Horuk R., 2007. Chemokines. Scientific World J. 7, 224-232.
  • Howell G., Tisherman S. A., 2006. Management of sepsis. Surg. Clin. North. Am. 86, 1523-1539.
  • Indo Y., 2002 Genetics of congenital insensitivity to pain with anhidrosis (cipa) or hereditary sensory and autonomic neuropathy type iv. Clinical, biological and molecular aspects of mutations in trka(ntrk1) gene encoding the receptor tyrosine kinase for nerve growth factor. Clin. Auton. Res. 12 (Suppl. 1), 20-32.
  • Ingle R. A., Carstens M., Denby K. J., 2006. Pamp recognition and the plant-pathogen arms race. Bioessays. 28, 880-889.
  • Joris I., Majno G., Corey E. J., Lewis R. A., 1987. The mechanism of vascular leakage induced by leukotriene e4. Endothelial contraction. Am. J. Pathol. 126, 19-24.
  • Koj A., 1998. Termination of acute-phase response: Role of some cytokines and anti-inflammatory drugs. Gen. Pharmacol. 31, 9-18.
  • Kolaczkowska E., 2002. Shedding light on vascular permeability during peritonitis: Role of mast cell histamine versus macrophage cysteinyl leukotrienes. Inflamm. Res. 51, 519-521.
  • Kolaczkowska E., Shahzidi S., Seljelid R., van Rooijen N., Plytycz B., 2002. Early vascular permeability in murine experimental peritonitis is comediated by resident peritoneal macrophages and mast cells: Crucial involvement of macrophage-derived cysteinyl-leukotrienes. Inflammation 26, 61-71.
  • Kolaczkowska E., Chadzinska M., Scislowska-Czarnecka A., Plytycz B., Opdenakker G., Arnold B., 2006. Gelatinase b/matrix metalloproteinase-9 contributes to cellular infiltration in a murine model of zymosan peritonitis. Immunobiology 211, 137-148.
  • Legrand D., Elass E., Carpentier M., Mazurier J., 2005. Lactoferrin: A modulator of immune and inflammatory responses. Cell Mol. Life Sci. 62, 2549-2559.
  • Lewis T., 1927. The blood vessels of the human skin and their responses. London, Shaw & Sons.
  • Majno G., Joris I., 2004. Cells, tissues, and disease : Principles of general pathology. Oxford, Blackwell.
  • Marcenaro E., Della Chiesa M., Dondero A., Ferranti B., Moretta A., 2007. It's only innate immunity but I like it. Adv. Exp. Med. Biol. 590, 89-101.
  • Marjolin J.-N., 1828. Ulcere. [W:] Dictionnaire de medecine. Bechet (ed.). Paris: Pratique, 31-50.
  • Marshall J. C., Malam Z., Jia S., 2007. Modulating neutrophil apoptosis. Novartis Found. Symp. 280, 53-66; discussion 67-72, 160-164.
  • Maruotti N., Cantatore F. P., Crivellato E., Vacca A., Ribatti D., 2007a. Macrophages in rheumatoid arthritis. Histol. Histopathol. 22, 581-586.
  • Maruotti N., Crivellato E., Cantatore F. P., Vacca A., Ribatti D., 2007b. Mast cells in rheumatoid arthritis. Clin. Rheumatol. 26, 1-4.
  • Matzinger P., 2007. Friendly and dangerous signals: Is the tissue in control? Nat. Immunol. 8, 11-13.
  • Mizoguchi A., Bhan A. K., 2006. A case for regulatory b cells. J. Immunol. 176, 705-710.
  • Muller W. A., 2003. Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. Trends Immunol. 24, 327-334.
  • Nagata M., 2005. Inflammatory cells and oxygen radicals. Curr. Drug Targets Inflamm. Allergy 4, 503-504.
  • Nemes Z., Steinert P. M., 1999. Bricks and mortar of the epidermal barrier. Exp. Mol. Med. 31, 5-19.
  • Ochoa J. B., Makarenkova V., 2005. T Lymphocytes. Crit. Care Med. 33, S510-S513.
  • Opdenakker G., Van den Steen P. E., Dubois B., Nelissen I., Van Coillie E., Masure S., Proost P., Van Damme J., 2001. Gelatinase b functions as regulator and effector in leukocyte biology. J. Leukoc. Biol. 69, 851-859.
  • Peters-Golden M., Canetti C., Mancuso P., Coffey M. J., 2005. Leukotrienes: Underappreciated mediators of innate immune responses. J. Immunol. 174, 589-594.
  • Rather L. J., 1971. Disturbance of function (functio laesa): The legendary fifth cardinal sign of inflammation, added by galen to the four cardinal signs of celsus. Bull. N. Y. Acad. Med. 47, 303-322.
  • Rocha e Silva M., 1994. A brief survey of the history of inflammation. Agents Actions 43, 86-90.
  • Roth J., Rummel C., Barth S. W., Gerstberger R., Hubschle T., 2006. Molecular aspects of fever and hyperthermia. Neurol. Clin. 24, 421-439.
  • Saito T., Gale M., Jr., 2007. Principles of intracellular viral recognition. Curr. Opin. Immunol. 19, 17-23.
  • Salmon J. K., Armstrong C. A., Ansel J. C., 1994. The skin as an immune organ. West J. Med. 160, 146-152.
  • Savill J., 1997. Apoptosis in resolution of inflammation. J. Leukoc. Biol. 61, 375-380.
  • Scott A., Khan K. M., Cook J. L., Duronio V., 2004. What is 'Inflammation'? Are we ready to move beyond celsus? Br. J. Sports Med. 38, 248-249.
  • Serhan C. N., Savill J., 2005. Resolution of inflammation: The beginning programs the end. Nat. Immunol. 6, 1191-1197.
  • Sherwood E. R., Toliver-Kinsky T., 2004. Mechanisms of the inflammatory response. Best Pract. Res. Clin. Anaesthesiol. 18, 385-405.
  • Silverstein A. M., 2003. Darwinism and immunology: From metchnikoff to burnet. Nat. Immunol. 4, 3-6.
  • Tedder T. F., Steeber D. A., Chen A., Engel P., 1995. The selectins: Vascular adhesion molecules. Faseb J. 9, 866-873.
  • Wang H., Ehnert C., Brenner G. J., Woolf C. J., 2006. Bradykinin and peripheral sensitization. Biol. Chem. 387, 11-14.
  • Wulfing C., Tskvitaria-Fuller I., Burroughs N., Sjaastad M. D., Klem J., Schatzle J. D., 2002. Interface accumulation of receptor/ligand couples in lymphocyte activation: Methods, mechanisms, and significance. Immunol. Rev. 189, 64-83.
  • Yoshimura A., Mori H., Ohishi M., Aki D., Hanada T., 2003. Negative regulation of cytokine signaling influences inflammation. Curr. Opin. Immunol. 15, 704-708.
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.