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Journal
2006 | 55 | 2-3 | 287-293
Article title

Kompleks arp2/3 jako kluczowy czynnik polimeryzacji aktyny

Content
Title variants
EN
The arp2/3 complex as a key factor of actin polymerization
Languages of publication
PL EN
Abstracts
EN
Directed motility of the cell is strictly dependent on regulation of the assembly/disassembly of actin filaments. New formed „daughter” filaments press against the membrane, thus generating a protrusive force, which is necessary for the initial stage of the movement. Precisely ordered geometry of „dendritic actin brush” results from the action of the Arp2/3 complex i. e. actin polymerization. The complex composition of seven evolutionarily conserved subunits among Eucaryota indicates the uniformity of its biological functions in the cell. Consequently, the Arp2/3 complex plays an important role not only in many physiological processes, such as embroygenesis, development of tissues, inflammatory response, wound healing, but also in propagating themselves of some intracellular pathogens through of the host’s plasma. Moreover, it has been shown, that the most suitable model of the Arp2/3 complex function is „the dendritic nucleation model”. The emerging issues requiring explanation seem to be interactions of individual subunits with each other, with „mother” and „daughter” filament, as well as with nucleation promoting factors, in the process of actin polymerization according to this model.
Keywords
Journal
Year
Volume
55
Issue
2-3
Pages
287-293
Physical description
Dates
published
2006
Contributors
  • Uniwersytet Mikołaja Kopernika w Toruniu Collegium Medicum im. L. Rydygiera w Bydgoszczy Katedra i Zakład Histologii i Embriologii, Karłowicza 24, 85-092 Bydgoszcz, Polska
author
  • Uniwersytet Mikołaja Kopernika w Toruniu Collegium Medicum im. L. Rydygiera w Bydgoszczy Katedra i Zakład Histologii i Embriologii, Karłowicza 24, 85-092 Bydgoszcz, Polska
  • Uniwersytet Mikołaja Kopernika w Toruniu Collegium Medicum im. L. Rydygiera w Bydgoszczy Katedra i Zakład Histologii i Embriologii, Karłowicza 24, 85-092 Bydgoszcz, Polska
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-ksv55p287kz
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