Kanały jonowe jako struktury modelowe

• Authors: Piotr Koprowski , Wojciech Grajkowski , Andrzej Kubalski

Title variants

EN

Bacterial ion channels as the model structures

• Languages of publication: PL EN

Abstracts

EN

Eukaryotic ion channels have been studied over the last fifty years and an extensive knowledge has been accumulated on their function. We know little, however, about their molecular structures. Most of the structural information on eukaryotic ion channels currently available results from homology modeling based on the structures of their bacterial homologues. The crystal structures of two prokaryotic potassium channels from S. lividans and M. thermautotrophicum served as good models for determining the molecular principles of gating in potassium channels. The channel from S. lividans provides also the best model of K+ selectivity. Based on the structure of another potassium channel that from Aeropyrum pernix, several models of voltage sensing have been proposed. The two bacterial mechanosensitive channels from E. coli are to date the best-characterized mechanosensitive channel molecules in terms of structure and function and they may provide an excellent model for understanding the general principles of mechanotransduction in biological membranes.

• Journal: Kosmos
• Year: 2005
• Volume: 54
• Issue: 4
• Pages: 373-379

Dates

published

2005

Contributors

author

Piotr Koprowski

• Zakład Biologii Komórki Instytut Biologii Doświadczalnej PAN, Pasteura 3, 02-093 Warszawa, Polska

author

Wojciech Grajkowski

• Zakład Biologii Komórki Instytut Biologii Doświadczalnej PAN, Pasteura 3, 02-093 Warszawa, Polska

author

Andrzej Kubalski

• Zakład Biologii Komórki Instytut Biologii Doświadczalnej PAN, Pasteura 3, 02-093 Warszawa, Polska

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