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Journal
2005 | 54 | 2-3 | 183-193
Article title

Dendryty też produkują białka: rola lokalnej syntezy w plastyczności połączeń synaptycznych

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EN
Local protein synthesis in neuronal dendrites: function in synaptic plasticity?
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PL EN
Abstracts
EN
The article summarizes the most meaningful studies which have provided evidence that protein synthesis in the neuron can occur not only in cell perikarya but also locally in dendrites. Dendrites contain the complete machinery required to synthesize proteins. Until now 12 different mRNAs coding the proteins involved in neurotransmission and modulation of synaptic activity have been identified in dendrites. Among these molecules is a BDNF neurotrophic factor which is a strong regulator of neuronal activity. It is postulated that the phenomenon of local synthesis provides the mechanism of fast changes in the strength of neuronal connections and is the molecular background of synaptic plasticity. Local protein synthesis points to some autonomy of dendrites which makes them 'the brains of the neurons' (Jim Eberwine).
Keywords
Journal
Year
Volume
54
Issue
2-3
Pages
183-193
Physical description
Dates
published
2005
Contributors
  • Zakład Neurofizjologii Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Pasteura 3, 02-093 Warszawa, Polska
References
  • AAKALU G., SMITH W. B., NGUYEN N., JIANG C., SCHUMAN E. M., 2001. Dynamic visualization of local protein synthesis in hippocampal neurons. Neuron 30, 489-502.
  • BAGNI C., MANNUCCI L., DOTTI C. G., AMALDI F., 2000. Chemical stimulation of synaptosomes modulates alpha-Ca2+/calmodulin-dependent protein kinase II mRNA association to polysomes. J. Neurosci. 20, RC76.
  • BAILEY E. A., IYER R. S., STONE M. P., HARRIS T. M., ESSIGMANN J. M., 1996. Mutational properties of the primary aflatoxin B1-DNA adduct. Proc. Natl. Acad. Sci. USA 93, 1535-1539.
  • BANNAI H., FUKATSU K., MIZUTANI A., NATSUME T., IEMURA S., IKEGAMI T., INOUE T., MIKOSHIBA K., 2004. An RNA-interacting protein, SYNCRIP (heterogeneous nuclear ribonuclear protein Q1/NSAP1) is a component of mRNA granule transported with inositol 1,4,5-trisphosphate receptor type 1 mRNA in neuronal dendrites. J. Biol. Chem. 279, 53427-53434.
  • BENSON D. L.,1997. Dendritic compartmentation of NMDA receptor mRNA in cultured hippocampal neurons. Neuroreport 8, 823-828.
  • BLICHENBERG A., SCHWANKE B., REHBEIN M., GARNER C. C., RICHTER D., KINDLER S., 1999. Identification of a cis-acting dendritic targeting element in MAP2 mRNAs. J. Neurosci. 19, 8818-8829.
  • BLISS T. V., COLLINGRIDGE G. L., 1993. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361, 31-39.
  • BODIAN D., 1965. A suggestive relationship of nerve cell RNA with specific synaptic sites. Proc. Natl. Acad. Sci. USA 53, 418-425.
  • BURGIN K. E, WAXHAM M. N, RICKLING S., WESTGATE S. A. MOBLEY W. C., KELLY P. T., 1990. In situ hybridization histochemistry of Ca2+/calmodulin-dependent protein kinase in developing rat brain. J. Neurosci. 10, 1788-1798.
  • CRINO P. B., EBERWINE J., 1996. Molecular characterization of the dendritic growth cone: regulated mRNA transport and local protein synthesis. Neuron 17, 1173-1187.
  • DUGICH-DJORDJEVIC M. M., TOCCO G., LAPCHAK P. A., PASINETTI G. M., NAJM I., BAUDRY M., HEFTI F., 1992. Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid. Neuroscience 47, 303-315.
  • FENG Y., GUTEKUNST C. A., EBERHART D. E., YI H., WARREN S. T., HERSCH S. M., 1997. Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritic ribosomes. J. Neurosci. 17, 1539-1547.
  • FREY U., MORRIS R. G., 1997. Synaptic tagging and long-term potentiation. Nature 385, 533-536.
  • FURUICHI T., SIMON-CHAZOTTES D., FUJINO I., YAMADA N., HASEGAWA M., MIYAWAKI A.,YOSHIKAWA S., GUENET J. L., MIKOSHIBA K., 1993. Widespread expression of inositol 1,4,5-trisphosphate receptor type 1 gene ( Insp3r1) in the mouse central nervous system. Receptors Channels 1, 11-24.
  • GARDIOL A., RACCA C., TRILLER A., 1999. Dendritic and postsynaptic protein synthetic machinery. J. Neurosci. 19, 168-179.
  • GARNER C. C., TUCKER R. P., MATUS A., 1988. Selective localization of messenger RNA for cytoskeletal protein MAP2 in dendrites. Nature 336, 674-677.
  • GAZZALEY A. H, BENSON D. L, HUNTLEY G. W, MORRISON J. H.,1997. Differential subcellular regulation of NMDAR1 protein and mRNA in dendrites of dentate gyrus granule cells after perforant path transection. J. Neurosci. 17, 2006-2017.
  • GOELET P., CASTELLUCCI V. F., SCHACHER S., KANDEL E. R., 1986. The long and the short of long-term memory - a molecular framework. Nature 322, 419-422.
  • HENN F. A., ANDERSON D. J., RUSTAD D. G., 1976. Glial contamination of synaptosomal fractions. Brain Res. 101, 341-344.
  • HERB A., WISDEN W., CATANIA M.V., MARECHAL D., DRESSE A., SEEBURG P. H., 1997. Prominent dendritic localization in forebrain neurons of a novel mRNA and its product, dendrin. Mol. Cell Neurosci. 8, 367-374.
  • JOB C., EBERWINE J., 2001. Identification of sites for exponential translation in living dendrites. Proc. Natl. Acad. Sci. USA 98, 13037-13042.
  • KIM H. K., KIM Y. B., KIM E. G., SCHUMAN E., 2005. Measurement of dendritic mRNA transport using ribosomal markers. Biochem. Biophys. Res. Commun. 328, 895-900.
  • KISS J., 1977. Synthesis and transport of newly formed proteins in dendrites of rat hippocampal pyramid cells. An electron microscope autoradiographic study. Brain Res. 124, 237-250.
  • LYFORD G. L., YAMAGATA K., KAUFMANN W. E., BARNES C. A., SANDERS L. K., COPELAND N. G., GILBERT D. J., JENKINS N. A., LANAHAN A. A., WORLEY P. F., 1995. Arc, a growth factor and activity-regulat-ed gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites. Neuron 14, 433-445.
  • MAYFORD M., BARANES D., PODSYPANINA K., KANDEL E. R., 1996. The 3'-untranslated region of CaMKII alpha is a cis-acting signal for the localization and translation of mRNA in dendrites. Proc. Natl. Acad. Sci. USA 93, 13250-13255.
  • MORI Y., IMAIZUMI K., KATAYAMA T., YONEDA T., TOHYAMA M., 2000. Two cis-acting elements in the 3' untranslated region of alpha-CaMKII regulate its dendritic targeting. Nat. Neurosci. 3, 1079-1084.
  • OUYANG Y., KANTOR D., HARRIS K. M., SCHUMAN E. M., KENNEDY M. B., 1997. Visualization of the distribution of autophosphorylated calcium/calmodulin-dependent protein kinase II after tetanic stimulation in the CA1 area of the hippocampus. J. Neurosci. 17, 5416-5427.
  • OUYANG Y., ROSENSTEIN A., KREIMAN G., SCHUMAN E. M., KENNEDY M. B., 1999. Tetanic stimulation leads to increased accumulation of Ca(2+)/ calmodulin-dependent protein kinase II via dendritic protein synthesis in hippocampal neurons. J. Neurosci. 19, 7823-7833.
  • PALACIOS-PRU E. L., PALACIOS L., MENDOZA R. V., 1981. Synaptogenetic mechanisms during chick cerebellar cortex development. J. Submicrosc. Cytol. 13, 145-167.
  • PENG J., KIM M. J, CHENG D., DUONG D. M., GYGI S. P., SHENG M., 2004. Semiquantitative proteomic analysis of rat forebrain postsynaptic density fractions by mass spectrometry. J. Biol. Chem. 279, 21003-11.
  • PIERCE J. P., VAN LEYEN K., MCCARTHY J. B., 2000. Translocation machinery for synthesis of integral membrane and secretory proteins in dendritic spines. Nat. Neurosci. 3, 311-313.
  • PRAKASH N., FEHR S., MOHR E., RICHTER D., 1997. Dendritic localization of rat vasopressin mRNA: ultrastructural analysis and mapping of targeting elements. Eur. J. Neurosci. 9, 523-532.
  • RACCA C., GARDIOL A., TRILLER A., 1997. Dendritic and postsynaptic localizations of glycine receptor alpha subunit mRNAs. J. Neurosci. 17, 1691-1700.
  • RAO A., STEWARD O., 1991. Evidence that protein constituents of postsynaptic membrane specializations are locally synthesized: analysis of proteins synthesized within synaptosomes. J. Neurosci. 11, 2881-2895.
  • ROZZO A., ARMELLIN M., FRANZOT J., CHIARUTTINI C., NISTRI A., TONGIORGI E., 2002. Expression and dendritic mRNA localization of GABAC receptor rho1 and rho2 subunits in developing rat brain and spinal cord. Eur. J. Neurosci. 15, 1747-1758.
  • SCHUMAN E. M., 1999. mRNA trafficking and local protein synthesis at the synapse. Neuron 23, 645-648.
  • SMART F. M, EDELMAN G. M., VANDERKLISH P. W., 2003. BDNF induces translocation of initiation factor 4E to mRNA granules: evidence for a role of synaptic microfilaments and integrins. Proc. Natl. Acad. Sci. USA 100, 14403-14408.
  • SMITH W. B, STARCK S. R, ROBERTS R. W, SCHUMAN E. M., 2005. Dopaminergic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons. Neuron 45, 765-779.
  • SPACEK J., 1985. Three-dimensional analysis of dendritic spines. II. Spine apparatus and other cytoplasmic components. Anat. Embryol. (Berl.) 171, 235-243.
  • STEWARD O., 1997. mRNA localization in neurons: a multipurpose mechanism? Neuron 18, 9-12.
  • STEWARD O., LEVY W. B., 1982. Preferential localization of polyribosomes under the base of dendritic spines in granule cells of the dentate gyrus. J. Neurosci. 2, 284-291.
  • STEWARD O., REEVES T. M., 1988. Protein-synthetic machinery beneath postsynaptic sites on CNS neurons: association between polyribosomes and other organelles at the synaptic site. J. Neurosci. 8, 176-184.
  • STEWARD O., WORLEY P. F., 2001. Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation. Neuron 30, 227-240.
  • STEWARD O., SCHUMAN E. M., 2003. Compartmentalized synthesis and degradation of proteins in neurons. Neuron 40, 347-359.
  • STEWARD O., WALLACE C. S, LYFORD G. L., WORLEY P. F., 1998. Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites. Neuron 21, 741-751.
  • SUTTON M.A., WALL N. R., AAKALU G. N., SCHUMAN E. M., 2004. Regulation of dendritic protein synthesis by miniature synaptic events. Science 304, 1979-1983.
  • TIEDGE H., BROSIUS J., 1996. Translational machinery in dendrites of hippocampal neurons in culture. J. Neurosci. 16, 7171-7181.
  • TONGIORGI E., RIGHI M., CATTANEO A., 1997. Activity-dependent dendritic targeting of BDNF and TrkB mRNAs in hippocampal neurons. J. Neurosci. 17, 9492-9505.
  • TONGIORGI E., ARMELLIN M., GIULIANINI P. G., BREGOLA G., ZUCCHINI S., PARADISO B., STEWARD O., CATTANEO A., SIMONATO M., 2004. Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis. J. Neurosci. 24, 6842-6852.
  • TORRE E. R., STEWARD O., 1992. Demonstration of local protein synthesis within dendrites using a new cell culture system that permits the isolation of living axons and dendrites from their cell bodies. J. Neurosci. 12, 762-772.
  • TORRE E. R., STEWARD O., 1996. Protein synthesis within dendrites: glycosylation of newly synthesized proteins in dendrites of hippocampal neurons in culture. J. Neurosci. 16, 5967-5978.
  • VERMA P., CHIERZI S., CODD A. M., CAMPBELL D. S., MEYER R. L., HOLT C. E., FAWCETT J. W., 2005. Axonal protein synthesis and degradation are necessary for efficient growth cone regeneration. J. Neurosci. 25, 331-342.
  • WANG H., IACOANGELI A., POPP S., MUSLIMOV I. A., IMATAKA H., SONENBERG N., LOMAKIN I. B., TIEDGE H., 2002. Dendritic BC1 RNA: functional role in regulation of translation initiation. J. Neurosci. 22, 10232-10241.
  • WEILER I. J., GREENOUGH W. T., 1993. Metabotropic glutamate receptors trigger postsynaptic protein synthesis. Proc. Natl. Acad. Sci. USA 90, 7168-7171.
  • WEILER I. J., WANG X., GREENOUGH W. T., 1994. Synapse-activated protein synthesis as a possible mechanism of plastic neural change. Prog. Brain Res. 100, 189-194.
  • WEILER I. J., IRWIN S. A., KLINTSOVA A. Y., SPENCER C. M., BRAZELTON A. D., MIYASHIRO K., COMERY T. A., PATEL B., EBERWINE J., GREENOUGH W. T., 1997. Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation. Proc. Natl. Acad. Sci. USA 94, 5395-5400.
  • WETMORE C., OLSON L., BEAN A. J., 1994. Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors. J. Neurosci. 14, 1688-1700.
  • ZHENG J. Q., KELLY T. K., CHANG B., RYAZANTSEV S., RAJASEKARAN A. K., MARTIN K. C., TWISS J. L., 2001. A functional role for intra-axonal protein synthesis during axonal regeneration from adult sensory neurons. J. Neurosci. 21, 9291-9303.
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-ksv54p183kz
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