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2004 | 53 | 3-4 | 315-323
Article title

Organizacja i funkcja ciałek Cajala

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Title variants
EN
Organization and functions of Cajal bodies
Languages of publication
PL EN
Abstracts
EN
Summary There ismuch interest in recent years in the possible role of different nuclear bodies (NBs) in cellular functions. NBs include the well-characterized Cajal bodies (CBs; or coiled bodies), which were first described in vertebrate neurons by Ramón y Cajal nearly 100 years ago and since then demonstrated in a variety of organisms and cell types, including both animals and plants. Cajal bodies contain C snurposomes with their associated B snurposomes. Many discussions of CB function emphasize their possible involvement in assembly, modification, or storage of RNA processing factors, especially small nucleolar ribonucleoprotein particles (snoRNPs), splicing small nuclear ribonucleoprotein particles (snRNPs), and the U7 snRNP. Moreover, some evidence suggests that CBs play an even wider role in transcription. Taking into account the composition of CBs and the targeting of various transcription and processing factors to CBs, we conclude that theymay be the primary site for assembly of the transcription machinery of the nucleus. The objective of this article is to summarize some aspects of these nuclear bodies, including their proposed roles in cells and in human diseases.
Keywords
Journal
Year
Volume
53
Issue
3-4
Pages
315-323
Physical description
Dates
published
2004
Contributors
  • Zakład Cytogenetyki Molekularnej Instytutu Genetyki i Hodowli Zwierząt PAN w Jastrzębcu, Jastrzębiec, Polska
  • Zakład Zachowania się Zwierząt Instytutu Genetyki i Hodowli Zwierząt PAN w Jastrzębcu, Jastrzębiec, Polska
  • Zakład Cytogenetyki Molekularnej Instytutu Genetyki i Hodowli Zwierząt PAN w Jastrzębcu, Jastrzębiec, Polska
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.bwnjournal-article-ksv53p315kz
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