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2004 | 53 | 3-4 | 243-249
Article title

Woda morska i dziury w błonach - Nagroda Nobla z chemii za rok 2003

Title variants
Sea water and holes in membranes - Nobel Prize in chemistry for 2003
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Summary The Nobel Prize in Chemistry for 2003 was awarded by the Royal Swedish Academy of Sciences in equal parts to two American scientists: Peter Agre from Johns Hopkins University School of Medicine in Baltimore, for the discovery of the water channels, aquaporins, and Roderick MacKinnon from Howard Hughes Medical Institute, the Rockefeller University in New York, for structural and mechanistic studies of the ion channels, especially the potassium and chloride channels. The major breakthrough made by the two scientists in our understanding of water and ion transport processes through biological membranes are briefly described in this editorial note, and the list of their recent selected publications is provided.
Physical description
  • Zakład Biochemii Komórki, Instytut Biologii Doświadczalnej im. M. Nenckiego PAN, Pasteura 3, 02-093 Warszawa, Polska
  • AGRE P., KING L. S., YASUI M., GUGGINO W. B., OTTERSEN O. P., FUJIYOSHI Y., ENGEL A., NIELSEN S., 2004. Aquaporinwater channels - from atomic structure to clinical medicine. J. Physiol. 542, 3-16.
  • AGRE P., KOZONO D., 2003. Aquaporin water channels: molecular mechanisms for human diseases. FEBS Lett. 555, 72-78.
  • AMIRY-MOGHADDAM M., WILLIAMSON A., PALOMBA M., EID T., DE LANEROLLE N. C., NAGELHUS E. A., ADAMS M. E., FROEHNER S. C., AGRE P., OTTERSEN O. P., 2003. Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of -syntrophin-null mice. Proc. Natl. Acad. Sci. USA 100, 13615-13620.
  • AMIRY-MOGHADDAM M., XUE R., HAUG F. M., NEELY J. D., BHARDWAJ A., AGRE P., ADAMS M. E., FROEHNER S. C., MORI S., OTTERSEN O. P., 2004. -Syntrophin deletion removes the perivascular but not endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia. FASEB J. 18, 542-544.
  • BEITZ E., PAVLOVIC-DJURANOVIC S., YASUI M., AGRE P., SCHULTZ J. E., 2004. Molecular dissection of water and glycerol permeability of the aquaglyceroporin from Plasmodium falciparum by mutational analysis. Proc. Natl. Acad. Sci. USA 101, 1153-1158.
  • BORGNIA M. J., AGRE P., 2001. Reconstitution and functional comparison of purified GlpF and AqpZ, the glycerol and water channels from Escherichia coli. Proc. Natl. Acad. Sci. USA 98, 2888-2893.
  • CARBREY J. M., BONHIVERS M., BOEKE J. D., AGRE P., 2001. Aquaporins in Saccharomyces: characterization of a second functional water channel protein. Proc. Natl. Acad. Sci. USA 98, 1000-1005.
  • DUTZLER R., CAMPBELL E. B., CADENE M., CHAIT B. T., MACKINNON R., 2002. X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity. Nature 415, 287-294.
  • DUTZLER R., CAMPBELL E. B., MACKINNON R., 2003. Gating the selectivity filter in ClC chloride channels. Science 300, 108-112.
  • FUJIYOSHI Y.,MITSUOKA K., DE GROOT B. L., PHILIPPSEN A., GRUBMULLER H., AGRE P., ENGEL A., 2002. Structure and function of water channels. Curr. Opin. Struct. Biol. 12, 509-515.
  • JIANG Y., LEE A., CHEN J., CADENE M., CHAIT B. T.,MACKINNON R., 2002. Crystal structure and mechanism of a calcium-gated potassium channel. Nature 417, 515-522.
  • JIANG Y., LEE A., CHEN J., CADENE M., CHAIT B. T., MACKINNON R., 2002. The open pore conformation of potassium channels. Nature 417, 523-526.
  • JIANG Y., LEE A., CHEN J. Y., RUTA V., CADENE M., CHAIT B. T.,MACKINNON R., 2003. X-ray structure of a voltage- dependent K+ channel. Nature 423, 33-41.
  • JIANG Y., RUTA V., CHEN J. Y., LEE A., MACKINNON R., 2003. The principle of gating charge movement in a voltage-dependent K+ channel. Nature 423, 42-48.
  • JIANG Q. X., WANG D. N, MACKINNON R., 2004. Electron microscopic analysis of KvAP voltage-dependent K+ channels in an open conformation. Nature 430, 806-810.
  • KING L. S., CHOI M., FERNANDEZ P. C., CARTRON J-P., AGRE P., 2001. Defective urinary-concentrating ability due to a complete deficiency of aquaporin-1. N. Engl. J. Med. 345, 175-179.
  • KING L. S., NIELSEN S., AGRE P., BROWN R. H., 2002. Decreased pulmonary vascular permeability in aquaporin- 1-null humans. Proc. Natl. Acad. Sci. USA 99, 1059-1063.
  • KOZONO D., YASUI M., KING L. S., AGRE P., 2002. Aquaporin water channels: atomic structure and molecular dynamics meet clinical medicine. J. Clin. Invest. 109, 1395-1399.
  • LEE S. Y.,MACKINNON R., 2004. Amembrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. Nature 430, 232-235.
  • MACKINNON R., 2003. Potassium channels. FEBS Lett. 555, 62-65.
  • MORAIS-CABRAL J. H., ZHOU Y., MACKINNON R., 2001. Energetic optimization of ion conduction rate by the K+ selectivity filter. Nature 414, 37-47.
  • MURATA K., MITSUOKA K., HIRAI T.,WALZ T., AGRE P., HEYMANN J. B., ENGEL A., FUJIYOSHI Y., 2000. Structural determinants of water permeation through aquaporin- 1. Nature 407, 599-605.
  • NEELY J. D., AMIRY-MOGHADAM M., OTTERSEN O. P., FROEHNER S. C., AGRE P., ADAMS M. E., 2001. Syntrophin-dependent expression and localization of aquaporin- 4 water channel protein. Proc. Natl. Acad. Sci. USA 98, 14108-14113.
  • NIELSEN S., FROKIAER J., MARPLES D., KWON T. H., AGRE P., KNEPPER M. A., 2002. Aquaporins in the kidney: from molecules to medicine. Physiol. Rev. 82, 205-244.
  • NISHIDA M.,MACKINNON R., 2002. Structural basis of inward rectification: cytoplasmic pore of the G protein- gated inward rectifier GIRK1 at 1.8 ? resolution. Cell 111, 957-965.
  • RUTA V., JIANG Y., LEE A., CHEN J. Y., MACKINNON R., 2003. Functional analysis of an archaebacterial voltage-dependent K+ channel. Nature 422, 180-185.
  • TSUBOTA K.,HIRAIS I.,KING L. S., AGRE P., ISHIDA N., 2001. Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjögren's syndrome. Lancet 357, 688-689.
  • VALIYAVEETIL F. I., ZHOU Y. F., MACKINNON R., 2002. Lipids in the structure, folding, and function of the KcsAK+ channel. Biochemistry 41, 10771-10777.
  • YASUI M.,HAZAMA A.,KWON T. H.,NIELSEN S.,GUGGINO W. B., AGRE P., 1999. Rapid gating and anion permeability of an intracellular aquaporin. Nature 402, 184-187.
  • YIFRACH O., MACKINNON R., 2002. Energetics of pore opening in a voltage-gated K+ channel. Cell 111, 231-239.
  • ZHOU M.,MACKINNON R., 2004. AmutantKcsAK+ channel with altered conduction properties and selectivity filter ion distribution. J. Mol. Biol. 338, 839-846.
  • ZHOU Y., MACKINNON R., 2004. Ion binding affinity in the cavity of the KcsA potassium channel. Biochemistry 43, 4978-4982.
Document Type
Publication order reference
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