Preferences help
enabled [disable] Abstract
Number of results
2003 | 52 | 2-3 | 249-258
Article title

Antyoksydanty obecne w diecie w walce z miażdżycą

Title variants
Antioxidants present in diet as anti atherosclerosis factors
Languages of publication
Summary This review presents the role of different antioxidants present in human diet and their effect on blood platelets. Blood platelet activation plays a crucial role in haemostasis and in pathomechanisms of several arterial disorders, including atherosclerosis. Antioxidants such as selenium compounds, "classical" vitamins (vitamin E and C), various phenolics (particularly resveratrol, a natural compound present in wine) and n-3 fatty acid counteract aggregation and adhesion of platelets and may reduce atherosclerosis.
Physical description
  • ABURJAI T. A., 2000. Anti-platelet stilbens from aerial parts of Rheum palaestinum. Phytochemistry 55, 407-410.
  • ARMSTRONG G. O., LAMBERCHTS M. G., MANSVELT E. P. G., VAN VELDEN D. P., PRETORIUS J. S., 2001. Wine and health. South African J. Sci. 97, 279-282.
  • ASHER G. J., BULTER G. W., PETERSON P. J., 1977. Selenium transport in root systems of tomato. J. Exp. Bot. 28, 279-291.
  • BAIS A. J.,MURPHY P. J.,DRY I. B., 2000. The molecular regulation of stilbene phytoalexin biosynthesis in Vitis vinifers during grape berry development. Aust. J. Plant. Physiol. 27, 425-433.
  • BANGANI V., CROUCH N. R., MULHOLLAND D. A., 1999. Homoisoflavanoes and stilbenoids from Scilla nervosa. Phytochemistry 51, 947-951.
  • BARNES M. J., FARNDALE R. W., 1999. Collagens and atherosclerosis. Exp. Gerantol. 34, 513-525.
  • BARTOSZ G., 1995. Miażdżyca. [W:] Druga twarz tlenu. G. BARTOSZ (red.). PWN, Warszawa, 222-225.
  • BERTELLI A. A, GIOVANNINI L., GIANNESSI D. Z., MIGLIORI M., BERNINI W., FREGONI M., BERTELLI A., 1995. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int. J. Tissue React. 17, 1-3.
  • BERTELLI A. A., GIOVANNINI L., BERNINI W., MIGLIORI M., FREGONI M., BAVERESCO L., BERTELLI A., 1996. Antiplatelet activity of cis-resveratrol. Drugs Exp. Clin. Res. 22, 61-63.
  • BLACHE D., GESQUIERE L., LOREAU N., DURAND P., 1999. Oxidant stress: the role of nutrients in cell-lipoprotein interactions. Proc. Nutrit. Soc. 58, 559-563.
  • BLOCKMANS D., DECKMYN H., VERMYLEN J., 1995. Platelet activation. Blood Rev. 9, 143-156.
  • BRAY T. M., 2000. Dietary antioxidants and assessment of oxidative stress. Nutrition 16, 578-581.
  • BURNS J., GARDNER P. T., O´NEAL., 2000. Relationship among antioxidant activity, vasodilation capacity, and phenolics content of red wines. J. Agric. Food Chem. 48, 220-230.
  • CATELLA-LAWSON F., 2001. Vascular biology of thrombosis.
  • Neurology 57, S5-S7.
  • CHRYSSELIS M. C., REKKA E. A., KOUROUNAKIS P. N., 2001. Antoxidant therapy and cardiovascular disorders. Exp. Opin. Ther. Patents 11, 33-34.
  • CHUNG M. I., TENG C. M., CHENG K. L., KO F. N., 1992. An antiplatelet principle of Veratrum Formosanum. Planta Med. 58, 274-276.
  • CROUCH N. R., BANGANI V., MULHOLLAND D. A., 1999. Homoisoflavonones from three South African Scilla species. Phytochemistry 51, 943-946.
  • DANIEL O., MEIER M. S., SCHLATTER J., FRISCHHNECHT P., 1999. Selected phenolic compounds in cultivated plants: ecologic functions, health implications, and modulation by pesticides. Environ. Health. Perspect. 107, 109-114.
  • DAS D. K., SATO M., RAY P. S., ENGELMAN R. M., BERTELLI A. A., BERTELLI A., 1999. Cardioprotection of red wine: role of polyphenolic antioxidants. Drugs Exp. Clin. Res. 25, 115-120.
  • DE VRIES J. H. M., HOLLMAN P. C. H., VAN AMERSFOORT I., OLTHOF M. R.,KATAN M. B., 2001. Red wine is a poor source of bioavailable flavonols in men. J. Nutr. 131, 745-748.
  • DOBRYDNEVA Y., WILLIAMS R. L., BLACKMORE P. F., 1999. Trans-resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br. J. Pharmacol.
  • 128, 149-157.
  • DREOSTI I. E., 2000. Antioxidant polyphenols in tea, cocoa, and wine. Nutrition 16, 692-694.
  • EUROLA M., EKHOLM P., YLINEN M., KOIVISTOINEN P., VARO P., 1989. Effects of selenium fertilization on the se- lenium content of selected finnish fruits and vegetables. Acta Agric. Scand. 39, 345-350.
  • FRANKEL E. N.,KANNER J.,GERMAN J. B., PARKS E.,KINSELLA J. E., 1993. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341, 454-457.
  • FREMONT L., BELGUENDOUZ L., DELPAL S., 1999. Antioxidant activity of resveratrol and alcohol-free wine polyphenols related to LDL oxidation and polyunsaturated fatty acids. Life Sci. 64, 2511-2521.
  • FREMONT L., 2000. Biological effects of resveratrol. Life Sci. 66, 663-673.
  • GIESSEL-NIELSEN G., GUPTA U. C., LAMAND M., WESTERMARCK T., 1984. Selenium in soils and plants and its importance in livestock and human nutrition. Adv. Agronom. 37, 397-460.
  • HACKENG CH. M., HUIGSLOOT M., PLADET M. W., NIEUWENHUIS H. K., VAN RIJN H. J. M., AKKERMAN J. W. N., 1999. Low-density lipoprotein enhances platelet secretion via integrin α-IIb3-mrdiated signaling.
  • Arterioscler. Thromb. Vasc. Biol. 19, 239-247.
  • HALLIWELL B., 2000. Lipid peroxidation, antioxidants and cardiovascular disease: how should we move forward. Cardiovasc. Res. 47, 410-418.
  • HIPSKIND J. D. , PAIVA N. L., 2000. Constitutive accumulation of a resveratrol-glucoside in transgenic alfa incrases resistance to Phoma medicaginis. MPMI 13, 551-562.
  • HUNG L. M., CHEN J. K., HUANG S. S., LEE R. S., SU M. J., 2000. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovasc. Res. 47, 549-555.
  • ITO T., TANAKA T., IDO Y., NAKAYA K., INUMA M., RISWAN S., 2000. Stilbenoids isolated from stem bark of Shorea hemsleyana. Chem. Pharm. Bull. 48, 1001-1005.
  • IULIANO L., COLAVITA A. R., LEO R., PRACTICO D., VIOLI F., 1997. Oxygen free radicals and platelet activation. Free Rad. Biol. Med. 22, 999-1006.
  • JOHNSON J. L., MADDIPATI K. R., 1998. Paradoxical effects of resveratrol on the two prostaglandin H synthases. Prostaglan. Lipid. Med. 56, 131-143.
  • KOBAYASHI S., DING C. K., NAKAMURA Y., NAKAJIMA I., MATSUMOTO R., 2000. Kiwifruits (actinida deliciosa) transfered with a Vitis stilbene synthase gene produce piceid (resveratrol-glukoside). Plant Cell. Rep. 19, 904-910.
  • KOHL-MUNZER E., 1993. Farmakognozja. PZWL, Warszawa.
  • KROLL M. H., SCHAFER A. J., 1995. The analysis of ligand- receptor interaction in platelet activation. Immunopharmacol, 29, 31-65.
  • LEVY-TOLEDANO S., 1999. Platelet signal transduction pathways: could we organize them into a hierarchy? Haemostasis 29, 4-15.
  • LIN W. Y., TENG CH. M., TSAI I. L., CHEN I. S., 2000. Anti- platelet aggregation constituents from Gynura elliptica. Phytochemistry 53, 833-836.
  • LYONS T. J., 1991. Oxidized low density lipoproteins: a role in the pathogenesis of atherosclerosis in diabetes? Diabetic Med. 8, 411-419.
  • MAHFOUZ M. M., KUMMEROW F. A., 1998. Oxysterols and TBARS are among the LDL oxidation products which enhance thromboxane A2 synthesis by platelets. Prostaglandins Other Lipid Mediat. 56, 197-217.
  • MALLE E., SALTLER W., 1994. Platelets and the lipoproteins: native, modified and platelet modified lipoproteins. Platelets 5, 70-83.
  • MALLE E., IBOVNIK A., STEINMETZ A., KOSTNER G. M., SATTLER W., 1994. Identification of glycoprotein IIb as the lipoprotein(a)-binding protein on platelets. Arterioscler. Thromb. 14, 345-352.
  • MANNA S. K., MUKHOPADHYAY A., AGGARWAL B. B., 2000. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-B, activator protein- 1, and apoptosis: potencial role of reactive oxygen intermediates and lipid peroxidation. J. Immunol. 164, 6509-6519.
  • MARTINEZ J., MORENO J. J., 2000. Effect of resveratrol, a natural polyphenolic compound, on reactive oxygen species and prostaglandin production. Biochem. Pharmacol. 59, 865-870.
  • MIDDLETON E., KANDASWAMI C., THEOHARIDES T. C., 2000. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol. Res. 52, 673-751.
  • MUTANEN M., FREESE R., 2001. Fats lipids and blood coagulation. Curr. Opin. Lipidol. 12, 25-29.
  • NIEUWENHOUYS C. M. A., FEIJGE M. A. H., OFFERMANS R. F. G., KESTER A. D. M., HOMSTRA G., 2001. Modulation of rat platelet activation by vessel wall-derived prostaglandin and platelet-derived thromboxane: thromboxane-prostaglandin balance. Artherosclerosis 154, 355-366.
  • NOGUCHI N., YOSHIDA Y., KANEDA H., YAMAMOTO Y., 1992. Action of ebselen as an antioxidant against lipid peroxidation. Biochem. Pharmacol. 1, 39-44.
  • OLAS B., WACHOWICZ B., SALUK-JUSZCZAK J., SZEWCZUK J., KACA W., 2001a. The effect of resveratrol on the platelet secretory process induced by endotoxin and thrombin. Microbios 105, 7-13.
  • OLAS B., WACHOWICZ B., 1995. Aktywacja płytek krwi; mechanizm przekazywania sygnałów. Post. Biol. Kom. 4, 359-378.
  • OLAS B., ŻBIKOWSKA H. M., WACHOWICZ B., KRAJEWSKI T., BUCZYŃSKI A., MAGNUSZEWSKA A., 1999. Inhibitory effect of resveratrol on free radical generation in blood platelets. Acta Biochim. Polon. 46, 991-996.
  • OLAS B., WACHOWICZ B., 2001. Biologiczna aktywność resweratrolu. Post. Hig. Med. Dośw. 1, 71-79.
  • OLAS B., WACHOWICZ B., SALUK-JUSZCZAK J., ZIELIŃSKI T., KACA W., BUCZYŃSKI A., 2001b. Antioxidant activity of resveratrol in endotoxin - stimulated blood platelets. Cell Biol. Toxicol. 17, 10-19.
  • OLESZEK W., SITEK M., STOCHMAL A., PIACENTE A., PIZZA C., CHEEKE P., 2000. Resveratrol and other phenolics from the bark of Yucca scjidigera Roezl. J. Agri. Food Chem. 49, 747-52.
  • PACE-ASCIAK C. R., HAHN S., DIAMANDIS E. P., SOLEAS G., GOLDBERG D. M., 1995. The red wine phenolics, trans-resveratrol and quercetin block human platelet aggregation and eicosanoids synthesis: implication for protection against coronary heart disease. Clin. Chim. Acta 23, 207-219.
  • PETERS R. J. G., MOONS A. H. M., 2001. Platelet function and coronary artery disease. Eur. J. Clin. Invest. 31, 3-5.
  • PIERPOINT W. S., 1994. Salicylic acid and its derivatives in plants: medicines, metabolites and messenger molecules. Adv. Bot. Res. 20, 163-233.
  • RAHMAN K., BILLINGTON D., 2000. Dietary supplemention with aged garlic extract inhibits ADP-induced platelet aggregation in humans. J. Nutr. 130, 2662-2665.
  • RASO G. M., MELI M., DI CARLO G., PARCILIO M., DI CARLO R., 2001. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage. Life Sci. 68, 921-931.
  • REIN D., PAGLIERONI T. G., WUN T., PEARSON D. A., SCHMITZ H. H., GOSSELIN R., KEEN C. L., 2000. Cocoa inhibits platelet activation and function. Am. J. Clin. Nutr. 72, 30-35.
  • RENAULD S., DE LORGERIL M., 1992. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339, 1523-1526.
  • ROTONDO S., ROTILIO D., CERLETTI CH., DE GAETANO G., 1996. Red wine, aspirin and platelet function. Thromb. Haemostas. 76, 813-821.
  • RUF J. C., 1999. Wine and polyphenols related to platelet aggregation and atherothrombosis. Drug Exp. Clin. Res. 25, 125-131.
  • RUSSO A., ACQUAVIVA R., CAMPISIS A., SORRENTI V., DI GIACOMO C., VIRGATA G., BARCELLONA M. L., VANELLE A., 2000. Bioflavonoids as antiradicals, antioxidants and DNA cleavage protectors. Cell Biol. Toxicol. 16, 91-98.
  • SATO M., RAY P. S., MAULIK G., MAULIK N., ENGELMAN R. M., BERTELLI A. A. E., BERTELLI A.,DAS D. K., 2000. Myocardial protection with red wine extract. J. Cardiovasc. Pharmacol. 35, 263-268.
  • SCHRAMM D. D., WANG J. F., HOLT R. R., ENSUNSA J. L., GONSALVES J. L., LAZARUS S. A., SCHMITZ H. H.,GERMAN J. B., KEEN C. L., 2001. Chocolate procyanidins decrease the leukotriene-prostacyclin ratio in humans and human aortic endothelial cells. Am. J. Clin. Nutr. 73, 36-40.
  • SCHOENE N. W., GUIDRY C. A., 2000. Dietary soy isoflavones inhibit activation of rat platelets. J. Nutr. Biochem. 10, 421-426.
  • SCHWENKE D. C., BEHR S. R., 1998. Vitamin E combined with selenium inhibits atherosclerosis in hypercholesterolemic rabbits independently of effects on plasma cholesterol concentrations. Circ. Res. 83, 366-377.
  • SMITH E. B., 1991. Lipids, lipoproteins and antioxidants in cardiovascular dysfunction. Biochem. Soc. Transac. 19, 235-241.
  • SOBKOWIAK A., 1997. In vino sanitas. Wiedza i Życie 12, 22-24.
  • SOBOLEV V. S., COLE R. J., 1999. Trans-resveratrol content in commercial peanuts and peanut products. J. Agric. Food Chem. 47, 1435-1439.
  • SOLEAS G. J., YAN J., GOLDBERG D. M., 2001. Measurement of trans-resveratrol (+) - catechin, and quercetin in rat and human blood and urine by gas chromatography with mass selective detection. Methods Enzym. 335, 130-144.
  • SPAGNOLO A., MORISI G., RIGHETTI G., MAIETTA A., MENOTTI A., 1991. Serum selenium and precursors of cardiovascular risk factor in adolescents. Eur. J. Epidemiol. 7, 654-657.
  • TADOLINI B., JULIANO C., PIU L., FRANCONI F., CABRINI L., 2000. Resveratrol inhibition of lipid peroxidation. Free Rad. Res. 33, 105-114.
  • TAKAHASHI Y., FUDA H., YANAI H., AKITA H., SHUPING H., CHIBA H., MATSUNO K., 1998. Significance of membrane glycoproteins in platelet interaction with oxidized low-density lipoprotein. Semin. Thromb. Hemost. 24, 251-253.
  • TANAKA T., ITO T., NAKAYA K., INUMA M., RISWAN S., 2000a. Oligostilbenoids in stem bark of Vatica rassak. Phytochemistry 54, 6-69.
  • TANAKA T., ITO T., OHYAMA M., ICHISE M., TATEISHI Y., 2000b. Stilbene oligomers in roots of Sophora davidii. Phytochemistry 53, 1009-1014.
  • THOMAS M. J., 2000. Physiological aspects of low-density lipoprotein oxidation. Curr. Opin. Lipidol. 11, 297-301.
  • VAN ACKER F. A. A., SCHOUTEN O., HAENEN G. R. M., VAN DER VIJGH W. J. F., BAST A., 2000. Flavonoids can replace -tocopherol as an antioxidant. FEBS Let. 473, 145-148.
  • VASTANO B. C., CHEN Y., ZHU N., HO C. T., ZHOU Z., ROSEN R. T., 2000. Isolation and identification of stilbens in two varieties of Polygonum cuspidatum. J. Agric. Food Chem. 48, 253-256.
  • VISIOLI F., BORSONI L, GALLI C., 2000. Diet and prevention of coronary heart disease: the potential role of phytochemicals. Cardiovasc. Res. 47, 419-425.
  • VLASOVA I., 2000. The effect of oxidatively modified low-density lipoproteins on platelet aggragability and membrane fluidity. Platelets 11, 406-414.
  • WU J. M., WANG Z. R., HSIEH T. C. H., BRUDER J. L., ZOU J. G., HUANG Y. Z., 2001. Mechanism of cardioprotection by resveratrol, a phenolics antioxidant present in red wine Int. J. Mol. Med. 8, 3-17.
  • ZHANG M., ZHANG J. P., JI H. T., WANG J. S., QIAN D. H., 2000. Effect of six flavonoids on proliferaction of hepatic stellate cells in vitro. Acta Pharmacol. Sin. 21, 253-256.
  • ŻBIKOWSKA H. M., OLAS B., 2000. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J. Physiol. Pharmacol. 3, 513-520.
  • ŻBIKOWSKA H. M.,WACHOWICZ B., KRAJEWSKI T., 1999. Selenium compounds inhibit the biological activity of blood platelets. Platelets 10, 185-190.
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.