Struktura chromatyny a powstawanie i naprawa uszkodzeń DNA

• Authors: Piotr Widłak

Title variants

EN

Chromatin structure and DNA repair

• Languages of publication: PL EN

Abstracts

EN

Summary Chromatin structure modulates the rate of DNA damage formation and repair in different regions of eukaryotic genomes. Chromatin rearrangement takes place during repair to increase accessibility of damage to repair proteins. Activity of histone acetyltransferases and chromatin remodeling complexes seems to be essential for nucleosome rearrangement during repair. Once repair is completed, reconstitution of nucleosomes is required to recover primary chromatin structure. Such chromatin assembly is coupled to repair DNA synthesis. DNA damages induce some modifications to chromatin structure (e.g. phosphorylation of a histone H2A variant in response to DNA double-strand breaks). Such chromatin modifications may serve as signals recognized by DNA repair systems.

• Journal: Kosmos
• Year: 2002
• Volume: 51
• Issue: 1
• Pages: 5-12

Dates

published

2002

Contributors

author

Piotr Widłak

• Zakład Radiobiologii Dooewiadczalnej i Klinicznej Centrum Onkologii - Instytut im. Marii Składowskiej-Curie, Oddział w Gliwicach, Wybrzeże Armii Krajowej 15, 44-100 Gliwice, Polska

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