Effect of BSA Protein on the Contrast Properties of Magnetite Nanoparticles during MRI

• Authors: O. Strbak , M. Kubovcikova , L. Baciak , I. Khmara , D. Gogola , M. Koneracka , V. Zavisova , I. Antal , M. Masarova , A. Krafcik , P. Kopcansky , D. Dobrota , I. Frollo
• Languages of publication: EN

Abstracts

EN

The aim of the study was to establish whether there is a significant change in the MRI contrast of magnetite nanoparticles, after BSA protein binding on the surface of particles. The rationale is the applicability of this feature in clinical practice for the tracking of specific proteins which are often associated with various pathologies. Contrast agents could bind to this specific marker, with the change in MRI contrast indicating the presence of pathology. We found that changes in relative contrast acquired at low-field MRI offer potential for the differentiation of magnetite nanoparticles with and without BSA protein. However, the variations in the transverse relaxation time (T₂) and transverse relaxivity (r₂), acquired at high-field MRI, were too small to be applicable for biomedical applications.

Keywords

EN

87.61.-c; 75.75.Fk; 87.15.kp

Discipline

• 87.61.-c: Magnetic resonance imaging
• 87.15.kp: Protein-ligand interactions
• 75.75.Fk: Domain structures in nanoparticles

• Publisher: Institute of Physics, Polish Academy of Sciences
• Journal: Acta Physica Polonica A
• Year: 2017
• Volume: 131
• Issue: 4
• Pages: 1102-1104

Dates

published

2017-04

Contributors

author

O. Strbak

• Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia

author

M. Kubovcikova

• Institute of Experimental Physics, SAS, Watsonova 47, 040 01 Kosice, Slovakia

author

L. Baciak

• Faculty of Chemical and Food Technology, STU, Radlinskeho 9, 812 37 Bratislava, Slovakia

author

I. Khmara

• Institute of Experimental Physics, SAS, Watsonova 47, 040 01 Kosice, Slovakia

author

D. Gogola

• Institute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia

author

M. Koneracka

• Institute of Experimental Physics, SAS, Watsonova 47, 040 01 Kosice, Slovakia

author

V. Zavisova

• Institute of Experimental Physics, SAS, Watsonova 47, 040 01 Kosice, Slovakia

author

I. Antal

• Institute of Experimental Physics, SAS, Watsonova 47, 040 01 Kosice, Slovakia

author

M. Masarova

• Institute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia

author

A. Krafcik

• Institute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia

author

P. Kopcansky

• Institute of Experimental Physics, SAS, Watsonova 47, 040 01 Kosice, Slovakia

author

D. Dobrota

• Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4, 036 01 Martin, Slovakia

author

I. Frollo

• Institute of Measurement Science, SAS, Dubravska cesta 9, 841 04 Bratislava 4, Slovakia

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Identifiers

DOI

10.12693/APhysPolA.131.1102